Nucleotides

acetylated derivative from 3-(3-amino-3-carboxypropyl)uridine

3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)-5-methyluridine is a novel, modified monophosphate nucleoside that can be activated to the corresponding diphosphate by adenosine kinase. The antiviral activity of 3'-O-(t-Butyldimethylsilyl)-2'-O-(2-methoxyethyl)-5-methyluridine has been demonstrated in vitro and in vivo against various viruses including HIV. In addition, this nucleoside phosphoramidite is used for synthesizing DNA and RNA. This product is CAS No. 1221967-92-5, Phosphoramidites, High purity and has a high quality.

5'-O-DMT-N2-DMF-guanosine is a novel nucleoside that has been modified with an acetyl group on the 5'-hydroxyl group. This nucleoside has antiviral, anticancer and deoxyribonucleoside properties. It also activates diphosphate synthesis and inhibits protein synthesis. The drug is synthesized in high purity and quality, making it an excellent activator for phosphoramidites.

Isocytidine, also known as 2-amino-1-β-D-ribofuranosyl-4(1H)-pyrimidinone, have broad antitumor activity targeting indolent lymphoid malignancies.

2'-C-Methyladenosine 5'-triphosphate triethyl ammonium salt is a synthetic nucleotide analog of adenosine triphosphate (ATP), modified at the 2'-carbon of the ribose ring. This molecule has potential applications in biochemical, enzymatic, and antiviral research, particularly in studies involving RNA synthesis and viral RNA polymerases.

3'-Deoxyguanosine is a nucleic acid that is involved in the synthesis of polysaccharides and proteins. It has been shown to have an inhibitory effect on the synthesis of collagen, which may be due to its ability to increase hydrogen bonding between the nitrogen atoms and oxygen atoms. 3'-Deoxyguanosine has also been shown to have a protective effect on wheat germ extract, which may be due to its ability to inhibit oxidation reactions. The chemical structure of 3'-deoxyguanosine can be synthesized by reacting deoxyribose with sodium nitrate in the presence of sulfuric acid. This reaction can be monitored using electrochemical impedance spectroscopy (EIS).

2'-Deoxyuridine-5'-triphosphate trisodium salt is a fluorophore that is excited by the absorption of light at wavelengths of 365 nm. The emission spectrum ranges from 380 to 500 nm and has a maximum at 480 nm. 2'-Deoxyuridine-5'-triphosphate trisodium salt can be used as a labeling agent for metal ion, molecule, or macrocyclic ligand. It can also be used as an acceptor in fluorescence energy transfer experiments.

A cyclic nucleotide derivative derived from guanosine triphosphate (GTP).

2'-Azido-2'-deoxyuridine is a synthetic nucleoside analog of uridine in which the 2'-hydroxyl group on the ribose sugar is replaced with an azido group (-N₃), and the base is unmodified uracil. This modification alters the sugar's conformation and chemical reactivity, enabling the use of this analog in bioorthogonal labeling strategies, particularly through azide-alkyne "click" chemistry. Its incorporation into nucleic acids can influence polymerase recognition and chain elongation, making it a useful probe in studies of RNA synthesis, structure, and function.

The pyrimidine-4-carboxylic acid methyl ester is a neutralized derivative of the natural amino acid pyrimidine-4-carboxylic acid. It can be metabolized in vivo to the active form, bleomycin. The neutralized form is useful for the synthesis of betaines and other compounds. This product is also used as an intermediate in the synthesis of metastable carbenes that are difficult to synthesize by other means. Pyrimidine-4-carboxylic acid methyl ester has been used as a reagent in mass spectrometry to identify isotopomers and isomers. It can also be used as a precursor for chemical transfer reactions with carbenes.

2-Phenylaminoadenosine (2-PA) is a potent and selective inhibitor of the P2Y receptor. 2-PA has been shown to reduce myocardial infarct size in vivo in mice, which may be due to its ability to inhibit the release of dopamine from the brain. In addition, 2-PA binds to LPS receptors on endothelial cells, reducing the production of proinflammatory cytokines and preventing platelet aggregation. 2-PA also inhibits the activation of toll-like receptor 4 (TLR4) in human monocytes, leading to reduced expression of proinflammatory cytokines and increased expression of anti-inflammatory cytokines. 2-PA is an agonist that binds with high affinity to P2Y receptors on erythrocytes. This binding results in decreased adenosine triphosphate (ATP) production by adenosine deaminase, which leads to decreased intracellular calcium levels and inhibition of neutroph

A P2Y2 receptor agonist that has been studied in cystic fibrosis and retinal diseases such as retinal detachment. Denufosol was studied as an inhaled drug for cystic fibrosis, due to its ability to activate an alternative chloride channel and avoiding the defective CFTR chloride channel. This enhances hydration of the lung mucosa and improves mucociliary clearance.  The drug did not progress from phase III clinical trials. Denufosol resulted in subretinal fluid reabsorption in in vivo model of retinal detachment.

N6-Benzyladenosine 5'-triphosphate sodium salt - 10 mM aqueous solution is an analog of adenosine triphosphate (ATP). It is used in the study of protein kinase C. ATP and its analogs are able to phosphorylate proteins and regulate their activity. This study has shown that N6-benzyladenosine 5'-triphosphate sodium salt - 10 mM aqueous solution is an atp analog that activates protein kinase C, leading to the phosphorylation of proteins. This analog also inhibits tyrosine kinases, which may be due to its ability to inhibit the reuptake of serotonin and other transmitters.

Guanosine 5'-triphosphate disodium salt is a nucleotide that is involved in energy metabolism and intracellular Ca2+ levels. It also has been shown to be an important regulator of guanine nucleotide-binding, enzyme activities, and receptor activity. This compound is a substrate for the polymerase chain reaction, which can be used to amplify DNA sequences. Guanosine 5'-triphosphate disodium salt has been shown to inhibit the growth of bacterial cells by binding to the antibiotic thiostrepton. The inhibition of bacterial growth is due to the prevention of antibiotic binding to bacterial ribosomes.

1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine is a nucleoside analog with a modified ribofuranosyl sugar, which includes a 2'-O-4'-C-methylene bridge that constrains the sugar conformation.

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite is a synthetic, antiviral monophosphate nucleoside. It is an activator that increases the activity of other nucleosides and can be used in DNA synthesis by incorporation into DNA molecules. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite has been shown to be effective against Hepatitis C virus, Human Immunodeficiency Virus 1 (HIV), and Herpes Simplex Virus 1.

2',3',5'-Tri-O-acetyl-6-azauridine is a nucleoside analog for research purposes. The replacement of a carbon atom with a nitrogen atom on the uracil base affects how the molecule interacts with cellular processes. It has the potential to interfere with normal metabolic processes within cells, particularly those related to RNA synthesis. Due to its ability to disrupt cell growth, it could be studied for any potential antiviral or antitumor properties.

N1,O2'-Dimethyladenosine is a monophosphate that is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. This drug is synthesized from diphosphate and phosphoramidites. N1,O2'-Dimethyladenosine has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications.

N1-Methylguanosine is a methylated nucleotide that is incorporated into the growing DNA chain during protein synthesis. The incorporation of N1-methylguanosine into the growing DNA chain can cause frameshifting, which creates an unusual amino acid sequence. This effect has been shown in model organisms, such as Saccharomyces cerevisiae and Escherichia coli. In these organisms, N1-methylguanosine has been shown to induce cancer when added to the growth medium. It is also found in urine samples from people with bladder cancer and has been used to identify urinary tract cancers. Titration calorimetry studies have shown that N1-methylguanosine binds to a chelate ligand and forms a disulfide bond with cysteine residues on proteins or peptides, which may lead to mitochondrial dysfunction by interfering with hydrogen bonding interactions. Messenger RNA studies show that N1-methylguanosine inhibits translation of mRNA by binding to

2'-Deoxyinosine-5'-monophosphate disodium salt is a synthetic nucleoside, phosphoramidite, and diphosphate that is used in the synthesis of DNA. It has been shown to have antiviral effects against HIV and herpes simplex virus type 2 (HSV-2). This drug also has anticancer activity and is an activator of novel nucleosides.

8-Azido-ATP is a novel nucleoside that has been shown to be an activator of DNA and RNA synthesis in human cells. It is synthesized by the enzymatic transfer of a gamma-biotin moiety from ATP to dATP, resulting in 8-azido-ATP. This drug has antiviral and anticancer activity and has been shown to inhibit the replication of HIV. The 8-azido-ATP can be used as an activator for purine nucleotide incorporation into DNA or RNA, which may help with cancer treatment or prevention. 8-Azido-ATP also inhibits the growth of certain viruses, such as herpes simplex virus type 1 (HSV1) and cytomegalovirus (CMV).

2'-O-Methyl-N6-phenoxyacetyladenosine is a phosphoramidite nucleoside that is used in the synthesis of DNA and RNA. It has antiviral, anticancer, and antiribonucleases properties. The chemical structure of 2'-O-Methyl-N6-phenoxyacetyladenosine is similar to that of adenosine, but contains a methyl group on C2' position and an oxyalkyl group on N6. This compound can be used as a novel anticancer agent and has been shown to have high affinity for the purine receptor, inhibiting cancer cell proliferation by activating the p53 tumor suppressor pathway.

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine (BDF) is a novel phosphoramidate prodrug of cytosine that has been synthesized for use in antiviral therapy. It is a DNA chain terminator and inhibits viral replication by inhibiting the synthesis of viral DNA. BDF is activated to cytosine monophosphate (CMP) by phosphodiesterase enzymes and then converted to cytosine diphosphate (CDP), which inhibits DNA synthesis. The synthesis of viral RNA is also inhibited, leading to inhibition of protein synthesis and cell death.

2,6-Dichloro-9-(β-D-ribofuranosyl)purine is a nucleoside analog composed of a modified purine base and a ribose sugar. It has possible applications as an intermediate in nucleoside chemistry, particularly for the synthesis of functionalized purine nucleosides used in biological and pharmaceutical research.

Adenosine 5'-diphosphate bis(cyclohexylammonium) salt is a novel antiviral agent that has been shown to be an activator of the adenylate cyclase enzyme. It also inhibits DNA and RNA synthesis in viruses, which prevents viral replication. Adenosine 5'-diphosphate bis(cyclohexylammonium) salt is active against cancer cells and has been shown to inhibit tumor growth and prolong survival in animal models. This compound can be synthesized by reacting the monophosphate with phosphoramidites or deoxyribonucleosides.

2'-Deoxy-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine is a novel and synthetic nucleoside analog with antiviral activity. It inhibits the synthesis of DNA by binding to the enzyme ribonucleotide reductase. This compound has been shown to be an activator of PPARs in vitro.

Acetyl coenzyme A trilithium salt (ACAT) is a prodrug that is metabolized in vivo to the active form, acetyl coenzyme A. Acetyl coenzyme A has been shown to inhibit the growth of human carcinoma cells and some typhimurium strains. It binds to cytochrome P450, which is involved in the oxidation of acetate and other organic substrates. ACAT has also been shown to be effective against squamous cell carcinoma by inhibiting the production of reactive oxygen species (ROS) in these cells. The anticancer activity of ACAT may be due to its ability to inhibit the conversion of amines into heterocyclic amines, which are known carcinogens.

1', 2', 3', 4', 5'- ¹³C5-Adenosine is adenosine which has all five carbon atoms of the ribose sugar replaced with the stable isotope carbon-13 (^13C). Possible applications are in proteomics studies.

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2-Chloropurine is a halogenated derivative of purine, a bicyclic nitrogen-containing heterocycle that forms the core of many biologically important molecules like DNA, RNA, ATP, and GTP. This molecule has applications in research

Pyruvate kinase substrate

2'-Deoxy-L-cytidine 3'-O-L-valinyl ester 2HCl is a nucleoside analog that is converted to its active form by intracellular dephosphorylation. It inhibits viral DNA polymerase, thereby preventing the replication of the virus. This drug has been shown to be effective against hepatitis B virus and influenza A virus. The triphosphate form of 2'-deoxy-3'-O-L-valinyl cytidine 2HCl is used as an antiviral agent in the treatment of chronic hepatitis and for prophylaxis against influenza A.

5,6-Dihydro-5-methyluridine is a nucleoside that is found in the human genome. It is a precursor of uridine and can be used to synthesize 5-methylcytosine, which is an epigenetic modification that occurs in DNA. This modification can affect the expression of genes by changing the structure of chromatin. This drug has been identified as a potential drug target for cancer treatment and other diseases. Structural analysis has shown that this compound has a number of hydrogen bonds with oxygen atoms and hydroxyl groups, which may make it more effective than other drugs currently being studied. 5,6-Dihydro-5-methyluridine forms a phylogenetic tree with other compounds that are also found in the human genome, suggesting that it may have evolved through natural selection.

Palmitoyl coenzyme A potassium salt is a novel, modified nucleoside that has antiviral and anticancer activities. It is a phosphoramidite with a phosphate group at one end and a palmitoyl group at the other. The phosphate group is attached to the 5' position of the sugar, while the palmitoyl group is attached to the 3' position of the sugar. Palmitoyl coenzyme A potassium salt can be used in DNA synthesis.

5-Carboxy-2'-deoxyuridine is a nucleoside analogue that inhibits herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) replication. It is used to treat genital herpes infections caused by HSV-1 or HSV-2. 5-Carboxy-2'-deoxyuridine has been shown to inhibit the growth of human cancer cells in culture, and is currently being investigated as a potential anticancer drug. This drug binds with high affinity to the viral DNA polymerase, forming a covalent bond with the uracil base in the viral DNA chain. This prevents further elongation of the chain, inhibiting viral replication. 5-Carboxy-2'-deoxyuridine also inhibits cellular protein synthesis and cell division, which may be due to its ability to bind with aldehyde groups on surfactant proteins.END>

2',3'-Dideoxy-5-iodocytidine is a modified nucleoside analog based on cytidine, one of the four standard nucleosides found in DNA and RNA. It has been chemically altered to interfere with DNA or RNA synthesis, making it potentially useful as an antiviral or anticancer agent.

5'-O-DMT-5-iodo-2'-O-methyluridine is an activator and antitumor agent that is used in the synthesis of 5'-O-DMT-5-iodo-2'-O-(2,4,6-trimethoxybenzoyl)uridine for cancer research. This chemical is a novel synthetic nucleoside with a high purity and quality that can be used to synthesize deoxyribonucleosides, nucleosides, and phosphoramidites. It has a CAS number of 588691-24-1. 5'-O-DMT-5-iodo-2'-O-(2,4,6 trimethoxybenzoyl)uridine can be used as an antiviral agent against HIV and other retroviruses.

N2-DMF-5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has antiviral, anticancer and immunomodulating properties. It is synthesized from 2′,3′-dideoxyadenosine 5′-monophosphate by the condensation of 2,6-dimethylaniline with methylguanosine 5′-monophosphate and 5,6-dimethylaniline. The modification of the guanine base in N2-DMF-5'-O-DMT-2'-O-methylguanosine to an O6 -methyl group results in increased affinity for the ribonucleotide reductase enzyme (RNR) and inhibition of DNA synthesis.

Anti-viral; anti-neoplastic

Uridine 5'-triphosphate dihydrate trisodium salt is a nucleotide that is involved in the synthesis of RNA. This product has been used as a supplement to promote healthy eyes and skin, as well as to treat Alzheimer's disease. It has been shown to be an efficient method for the detection of active substances by hydrophilic interaction chromatography (HILIC). The HILIC method involves separating molecules based on their hydrophobic or hydrophilic properties, which are determined by the ionic strength of the solution. Uridine 5'-triphosphate dihydrate trisodium salt binds with chloride ions, which prevents it from binding with other organic compounds. The chloride ions then serve as an end point that can be detected using ultraviolet light.

Activator of cGMP-dependent protein kinases

5'-O-(4,4'-Dimethoxytrityl)adenosine is a phosphoramidite that can be used as an activator for the synthesis of DNA. It is also used in the preparation of modified nucleosides and has anticancer activity. 5'-O-(4,4'-Dimethoxytrityl)adenosine is a modified ribonucleoside with high quality and high purity. This product has been shown to have antiviral activity against HIV-1.

8-Chloroadenosine-5'-monophosphate triethylammonium is a novel phosphoramidite that is used in the synthesis of DNA. 8-Chloroadenosine-5'-monophosphate triethylammonium has been shown to activate antiviral and anticancer drugs with high specificity. It is also used as a reagent for the synthesis of deoxyribonucleosides and nucleosides. 8-Chloroadenosine-5'-monophosphate triethylammonium has high purity and can be used in the synthesis of DNA, RNA, and other nucleosides.

N4-Acetyl-2'-deoxycytidine is a nucleoside analogue that acts as an inhibitor of DNA synthesis. It binds to the active site of the enzyme ribonucleotide reductase, blocking the conversion of ribonucleotides to deoxyribonucleotides. This prevents DNA synthesis and replication, which leads to cell death. N4-Acetyl-2'-deoxycytidine has been shown to be more efficient than other analogues in terms of energy efficiency, control levels, and constant linear model. This compound is reactive and can cause low yields when isolated from solutions with high concentrations. A diode can be used for analytical purposes, while calcium binding may be used as a mathematical model in order to analyze this drug.