Nucleotides

Adenosine-5'-diphosphate disodium salt is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2'-O-Methyluridine-5'-triphosphate sodium salt is a nucleoside containing a 2'-O-methyl group at the 5' position. It is a novel antiviral and anticancer agent that can inhibit viral replication and induce cell apoptosis. This drug has been shown to be effective against herpes simplex virus type 1 (HSV1) and Epstein-Barr virus (EBV) in vitro, as well as some tumor cells in vivo. 2'-O-Methyluridine-5'-triphosphate sodium salt has also been shown to have high purity and high quality, with less than 0.01% impurities by HPLC, NMR, and elemental analysis analyses.

Stearoyl coenzyme A free acid hydrate is a natural, non-synthetic lipid molecule that belongs to the group of fatty acids. It is found in the form of a white crystalline powder and has a melting point at approximately 56°C. Stearoyl CoA free acid hydrate is an essential component of cellular metabolism, carrying out reactions such as desaturase, dextran sulfate, and other enzyme activities. Stearoyl CoA free acid hydrate may have therapeutic applications for metabolic disorders and obesity. The enzyme complex that catalyzes the synthesis of stearoyl CoA free acid hydrate in adipocytes is ATP-binding cassette transporter (ABC) A1 and ABCG1, which are members of the superfamily of ATP-binding cassette (ABC) transporters. It also plays a role in regulating immune responses via Toll-like receptor 4 (TLR4).

2',3'-Dideoxy-3'-fluoro-a-uridine is a synthetic nucleoside analog. This compound is a modified version of uridine. The 2' and 3' hydroxyl groups on the sugar molecule are replaced with hydrogen atoms, and a fluorine atom replaces the hydrogen at the 3' position. This molecule has potential antiviral acitivty and can be used in research applications.

N4-Acetyl-2'-O-methylcytidine is a chemical compound that is an analog of cytidine. It has been shown to have the ability to stabilize RNA molecules at high temperatures and has been used in the study of epigenetics and thermophilic organisms. N4-Acetyl-2'-O-methylcytidine is also known as AEMC. This compound can be used for reversed phase high performance liquid chromatography, which separates compounds based on their size and shape. Furiosus is a strain of bacteria that contains this chemical compound in its genome. Furiosus was found to contain this compound in its DNA by using posttranscriptional modification techniques such as high performance liquid chromatography (HPLC) and proton nuclear magnetic resonance (NMR).

Second messenger in intracellular signal transduction

Coenzyme and regenerating electron donor in catabolic processes

1-(2’-Deoxy-2’-fluoro-arabinofuranosyl)-5-hydroxymethyluracil (also abbreviated as FMAU-OH) is a modified nucleoside analog. It consists of a fluorinated sugar moiety (2’-deoxy-2’-fluoro-arabinofuranose) attached to a uracil base with a hydroxymethyl (-CH₂OH) group at the 5-position. The 2’-fluoro substitution and arabinose sugar configuration can enhance its stability and affect its incorporation into DNA or RNA. It has the potential to be used as an inhibitor of viral polymerases and can be used in research.

2',3',5'-Tri-O-acetyl-8-bromoguanosine is a synthetic nucleoside analog that inhibits the growth of tumor cells. It has been shown to inhibit the progression of prostate cancer and cervical cancer by binding to guanosine, preventing its conversion into ATP. This compound also prevents proliferation in hek293 and glioblastoma cells. The mechanism of action may be due to oxidative phosphite formation, which causes DNA damage and subsequent apoptosis.

2'-C-Methyluridine is a synthetic nucleoside analog derived from uridine, modified with a methyl group at the 2'-carbon of the ribose sugar. This small chemical change has important implications for RNA biology, antiviral drug development, and biochemical research, especially in targeting RNA viruses.

Uridine-3',5'-cyclic monophosphate sodium salt is a phosphotriester that is an intermediate in the biosynthesis of nucleosides. It is also a phosphodiesterase inhibitor, which means it inhibits the breakdown of cyclic nucleotides and allows them to accumulate. This drug has been shown to increase platelet production and has anti-inflammatory effects. Uridine-3',5'-cyclic monophosphate sodium salt is a human metabolite that can be synthesized from uridine, which is present in DNA, RNA, and food sources such as meat, eggs, and milk. The synthesis of uridine-3',5'-cyclic monophosphate sodium salt requires phosphoramidite as a precursor.

Coenzyme and regenerating electron donor in catabolic processes

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-O-(2-methoxyethyl)adenosine is a modified nucleoside with antiviral activity. This compound is synthesized by a modified method that avoids the use of phosphoramidites, which are usually used to synthesize nucleosides. N6-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-O-(2-methoxyethyl)adenosine is an activator of viral RNA polymerase and has been shown to be active against HIV and herpes simplex virus type 1.

3'-Azido-5'-O-benzoyl-3'-deoxythymidine is a novel antiviral agent that is synthesized by modifying the structure of thymidine. It has been shown to have high antiviral activity against HIV and other viruses in vitro. 3'-Azido-5'-O-benzoyl-3'-deoxythymidine also inhibits tumor growth in animal models and may be useful as an anticancer drug. This compound is found to be active against a number of cancers, including leukemia, colon cancer, and prostate cancer. 3'-Azido-5'-O-benzoyl-3'-deoxythymidine is phosphoramidites for DNA synthesis, which can be used in the production of ribonucleosides or deoxyribonucleosides.