Nucleosides
Nucleosides are fundamental building blocks of nucleic acids, composed of a nitrogenous base attached to a sugar molecule. In this section, you can find a wide variety of nucleosides essential for research in molecular biology, biochemistry, and pharmacology. These compounds play crucial roles in the synthesis of DNA and RNA, and are also vital in various metabolic processes. Nucleosides are used in studying genetic material, developing antiviral and anticancer therapies, and understanding cellular mechanisms. At CymitQuimica, we provide high-quality nucleosides to support your research and development needs, ensuring purity and reliability for your experimental applications.
Products of "Nucleosides"
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5-Azido- 2'- deoxycytidine
CAS:5-Azido-2'-deoxycytidine is a high purity, novel, modified, and synthesized nucleoside with anticancer and antiviral properties. It is a diphosphate that is used in the synthesis of DNA as an activator. 5-Azido-2'-deoxycytidine has been shown to inhibit the growth of cancer cells and to be active against influenza virus.Formula:C9H12N6O4Purity:Min. 95%Molecular weight:268.23 g/mol3’-b-C-Methyluridine
CAS:3’-b-C-Methyluridine (3′-b-CMU) is an analog of uridine. It inhibits the activity of viral and bacterial nucleases by attacking the phosphate group. 3′-b-CMU inhibits syncytial formation in cell cultures, which may be due to its ability to inhibit RNA synthesis. This drug has a hydroxyl group that can react with free radicals and may have some inhibitory effect on deoxyribonucleoside triphosphate hydrolysis. 3′-b-CMU is not widely used clinically because it is not readily available, but it is being reinvestigated for use in corynebacterium infections.Purity:Min. 95%3'-Deoxy-5'-O-DMT-3'-fluoro-thymidine
CAS:3'-Deoxy-5'-O-DMT-3'-fluoro-thymidine (3'DFT) is a nucleoside that can be used as an anticancer drug. It is synthesized by the replacement of the 3'-hydroxyl group with a fluorine atom in 5'-O-DMT-3'-fluoro-thymidine. The synthesis of 3'DFT starts with the reaction of 5'O-(4,4'-dimethoxytrityl)-3'-deoxyuridine and 1,2,4,5-tetraisopropyldiazoacetate to form 5'O-(4,4'-dimethoxytrityl)-3'-deoxythymidine. This is followed by a reduction of the ester group to produce 5'O-(4,4'dimethoxytrityl)-3'F-thymidine. An acetate group is then added toFormula:C31H31FN2O6Purity:Min. 95%Molecular weight:546.59 g/mol5'-O-DMT-2,2'-anhydrouridine
CAS:5'-O-DMT-2,2'-anhydrouridine is a nucleoside that is an activator of RNA polymerase. This compound is novel and can be used for the synthesis of modified oligonucleotides and DNA. 5'-O-DMT-2,2'-anhydrouridine has anticancer properties and can be used in the treatment of cancer. 5'-O-DMT-2,2'-anhydrouridine has been shown to inhibit the growth of cancer cells by binding to DNA and inhibiting the production of RNA.Formula:C30H28N2O7Purity:Min. 95%Molecular weight:528.55 g/mol2-Nicotinamide-2,3,5-tri-O-acetyl-β-D-riboside bromide
CAS:2-Nicotinamide-2,3,5-tri-O-acetyl-β-D-riboside bromide is a novel antiviral agent that is structurally related to adenosine monophosphate. It has been shown to be active against Herpes Simplex Virus Type 1 (HSV1) and HSV2 in vitro. Its antiviral activity may be due to the inhibition of viral DNA synthesis and RNA transcription.Formula:C17H21BrN2O8Purity:Min. 95%Color and Shape:PowderMolecular weight:461.26 g/molRef: 3D-FN167158
Discontinued product2-Chloro-N6-cyclopentyladenosine hemihydrate
CAS:2-Chloro-N6-cyclopentyladenosine hemihydrate is a synthetic adenosine analog with potential research applicationsFormula:C15H20ClN5O4H2OPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:378.81 g/mol2'-Deoxy-5-iodocytidine
CAS:Anti-viral agent; iodinated analog of deoxycytidineFormula:C9H12IN3O4Purity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:353.12 g/molTroxacitabine
CAS:Troxacitabine is a nucleoside analog that inhibits DNA synthesis by selectively blocking the function of DNA polymerase. It has been shown to have potent antitumor activity in mouse tumor models and in a human breast cancer xenograft model. Troxacitabine has also been shown to inhibit the proliferation of renal cell cancer cells and induce apoptosis in these cells, as well as reduce the viability of cancer cells from other tumor types. Troxacitabine has also been shown to have an effect on body mass index and hematologic response, although it is not currently approved for use in humans.Formula:C8H11N3O4Purity:Min. 95%Color and Shape:White To Off-White SolidMolecular weight:213.19 g/molN6-Isopentenyladenosine-5'-monophosphate disodium
CAS:N6-Isopentenyladenosine-5'-monophosphate sodium salt is an adenosine conjugate acid. It is a monomer of polyribonucleotide chain, which is necessary for the formation of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). N6-Isopentenyladenosine-5'-monophosphate sodium salt is a conjugate base that has the ability to bind to DNA. This binding prevents the formation of a complex with RNA polymerase, thereby inhibiting transcription and replication.Formula:C15H22N5O7P•Na2Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:461.32 g/molN2-Isobutyryl-N-trityl-morpholino guanine
CAS:N2-Isobutyryl-N-trityl-morpholino guanine is a synthetic nucleoside analogue. It has been shown to be an activator of ribonucleotide reductase, and it is a potential anticancer agent. N2-Isobutyryl-N-trityl-morpholino guanine has also been shown to inhibit the replication of DNA and RNA viruses. This compound is being studied for its possible use in the treatment of HIV infection, as well as other viral infections that affect the central nervous system.Purity:Min. 95%Thymidine
CAS:Glycosylated pyrimidine analog; DNA componentFormula:C10H14N2O5Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:242.23 g/mol3'-Phosphoadenosine 5'-phosphosulfate triethylammnonium
CAS:Universal sulfonate donor for in vivo sulfonation by sulfotransferasesFormula:C10H15N5O13P2S•4C6H15NPurity:Min. 90 Area-%Color and Shape:PowderMolecular weight:912.03 g/molNicotinic acid riboside
CAS:Nicotinic acid riboside is a nicotinic acid derivative that has been shown to increase NAD+ levels in cells. Nicotinic acid riboside has been shown to increase the activity of enzymes involved in energy metabolism and transfer reactions, as well as target enzymes such as nicotinamide phosphoribosyltransferase (NAMPT) and its substrate, nicotinamide mononucleotide (NMN). It also increases cellular NAD+ levels by inhibiting the degradative enzyme, nicotinamide phosphoribosyltransferase (NAMPT). Nicotinic acid riboside can be used to treat metabolic disorders such as diabetes mellitus type 2.Formula:C11H13NO6Purity:Min. 95%Color and Shape:PowderMolecular weight:255.22 g/mol5-Fluoro-1-(b-L-ribofuranosyl)-uracil
CAS:5-Fluoro-1-(b-L-ribofuranosyl)-uracil is a triflate that is synthesized by the intramolecular, stereospecific reaction of l-guanosine and l-adenosine. It has been shown to have high yields in its synthesis. 5-Fluoro-1-(b-L-ribofuranosyl)-uracil can be used to produce glycosidations with d-galactose and l-thymidine. This product can also be used for the production of l-[5-(2,4,6-trimethoxybenzoyl)-1Hpyrazol]-3-[(2S,3R)-3-(bromomethyl)pyrrolidin]-2one (PBI), which is an inhibitor of protein kinase C.Purity:Min. 95%Xanthosine 5'-monophosphate disodium salt
CAS:Xanthosine 5'-monophosphate disodium salt is a nucleotide that has been shown to react with nitrite in aqueous solution to form xanthosine 5'-monophosphate. The reaction system can be prepared by adding nitrite to a solution of xanthosine 5'-monophosphate disodium salt and deionized water. The crystallization process can be done by adding ethanol dropwise to the reaction system under controlled conditions. Impurities may result from the preparation process, such as sodium chloride, sodium sulfate, and sodium hydroxide.Formula:C10H11N4Na2O9PPurity:Min. 95%Color and Shape:White Slightly Yellow PowderMolecular weight:408.17 g/mol2',3'-Didehydro-2',3'-dideoxyuridine
CAS:2',3'-Didehydro-2',3'-dideoxyuridine (DDDU) is a nucleoside analog that inhibits the formation of HIV. It is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication in cell culture, and has been shown to inhibit the production of HIV-1 virions in vitro. 2',3'-Didehydro-2',3'-dideoxyuridine has been shown to bind to the enzyme glycosyltransferase, which is required for HIV-1 replication. DDU also binds to human CD4+ T cells, deflecting them from the HIV-infected target cell. This compound may be useful as an antiviral agent against HIV-1 infection by inhibiting viral replication and infectivity.Formula:C9H10N2O4Purity:Min. 95%Molecular weight:210.19 g/mol5-Methoxy-4’-thiouridine
5-Methoxy-4’-thiouridine is a monophosphate nucleoside that is synthesized by the phosphorylation of 5-methoxy-4’-thioguanosine. It has antiviral activity, which is due to its ability to inhibit viral DNA polymerase and prevent the production of viral DNA. 5-Methoxy-4’-thiouridine also inhibits the synthesis of deoxyribonucleosides and ribonucleosides, thereby preventing the formation of RNA and DNA. This agent has been shown to be an anticancer agent that can cause cell death by inhibiting protein synthesis.Purity:Min. 95%5'-O-Levulinoylthymidine 3'-CE phosphoramidite
CAS:5'-O-Levulinoylthymidine 3'-CE phosphoramidite is a novel, high quality diphosphate nucleoside. It is modified with levulinic acid and has antiviral and anticancer properties. 5'-O-Levulinoylthymidine 3'-CE phosphoramidite is synthesized from 5'-O-levulinoylthymidine monophosphate, which is synthesized from thymidine and levulinic acid. The synthesis of 5'-O-levulinoylthymidine 3'-CE phosphoramidite starts with the reaction of 1 equivalent of thymidine with 1 equivalent of levulinic acid in aqueous solution at pH 7 to 8 at 100°C for 2 hours, followed by purification by HPLC.Formula:C24H37N4O8PPurity:Min. 95%Molecular weight:540.55 g/mol3'-Amino-5'-O-tert-butyldimethylsilyl-2',3'-dideoxyuridine
CAS:3'-Amino-5'-O-tert-butyldimethylsilyl-2',3'-dideoxyuridine is a synthetic nucleoside analog that inhibits viral replication. It is an activator of the immune system, which may be useful in treating some cancers. This nucleoside analog has been shown to have antiviral activity against herpes simplex virus type 1 (HSV-1) and HIV and to inhibit cell growth in human cancer cells.Formula:C15H27N3O4SiPurity:Min. 95%Molecular weight:341.48 g/mol
