Nucleosides

1-(2,3-Dideoxy-2-fluoropentofuranosyl)cytosine is a cytosine analog that is structurally similar to the antiviral drug tenofovir. It has been shown to be active against human serum and logarithmic growth phase cells, as well as cancer cell lines. 1-(2,3-Dideoxy-2-fluoropentofuranosyl)cytosine inhibits HIV infection in vitro by binding to the viral reverse transcriptase enzyme, blocking its activity and preventing DNA synthesis. This drug also inhibits the replication of human immunodeficiency virus type 1 (HIV-1) and other retroviruses in cell culture.

Ribonucleosides are nucleoside derivatives that can be used as antiviral agents. Ribonuclease (RNase) is a type of ribonucleoside that acts as an antiviral agent by inhibiting the synthesis of RNA in cells. Ribonuclease has been shown to inhibit the growth of HIV-1 and HIV-2 in vitro, and may also have therapeutic potential for other viruses such as herpes simplex virus-1 (HSV-1). Ribonuclease is synthetically modified to produce 1-(2',3',5'-tri-O-tert-butyldimethylsilyl-b-D-ribofuranosyl)-5-ethynylimidazo-[4,5,-c]-carbonitrile, an activator ribonucleoside with high purity and novel properties.

2'-O-Allyladenosine is a synthetic nucleoside analog that has been shown to be a competitive inhibitor of the enzyme guanosine kinase. It has a high yield and can be used as a synthon for the preparation of 2'-deoxyribose nucleosides. The alkylation of allyl groups onto adenosines provides an efficient method for synthesizing allylated purines, which are analogs with increased stability and affinity for DNA sequences. 2'-O-Allyladenosine has been shown to bind to DNA, RNA, and proteins. Its interaction with DNA is stronger than that of unmodified adenosine, due to the presence of two allyl groups that can form hydrogen bonds with the phosphate backbone. This interaction may also lead to increased affinity for sequences containing G-C base pairs.

6-Amino-3-iodo-4-methoxy-1-(beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a synthetic nucleoside that has antiviral activity. It is an activator of DNA polymerase and can be used to synthesize DNA and RNA. 6AIOMP binds to the ribonucleotide reductases in cells and inhibits their activity. This prevents the conversion of ribonucleotides into deoxyribonucleotides, which are essential for DNA synthesis.

Thymidine-5'-monophosphate disodium salt is a nucleoside that is synthesized by reductive phosphorylation of thymidine. It is a substrate for nucleotide synthesis and can be used as a reagent in the synthesis of oligonucleotides. Thymidine-5'-monophosphate disodium salt can be reduced to form thymidine, which can then be converted to 5-thio-2'-deoxyuridylate or 5-thio-2'-deoxycytidylate. This conversion takes place through the cleavage reaction of the thymidine residue from the disodium salt.

3’-Azido-3’-deoxy-b-L-adenosine is a novel nucleoside that has been synthesized to be used as an antiviral agent. It is phosphorylated, which allows it to be activated by adenosine kinase, and is thus able to inhibit viral replication and spread. 3’-Azido-3’-deoxy-b-L-adenosine is effective against various viruses, including HIV, herpes simplex virus type 1 (HSV1), and hepatitis C virus (HCV). This nucleoside also has anticancer activity due to its ability to inhibit the synthesis of DNA and RNA. It has been modified from the natural nucleosides with the addition of a 2′,3′ azido group at the 3 position on the ribose sugar. The modification prevents viral resistance because it does not require activation by cellular kinases or phosphorylation in order to be active.

Guanosine 5'-monophosphate, also known as GMP, is a ribonucleoside monophosphate that becomes incorporated into RNAs when phosphorylated to GTP.

6-Azathymidine is an antiviral agent that prevents the synthesis of viral DNA. It is a nucleoside analogue that contains a hydroxyl group at the 6 position on a pyrimidine ring. This compound has been shown to be effective in treating HIV infection and cancer, as well as herpes simplex virus and influenza virus. 6-Azathymidine inhibits the enzyme ribonucleotide reductase, which is responsible for converting ribonucleotides into deoxyribonucleotides, thereby blocking DNA synthesis. The phosphate derivatives of this drug have been shown to inhibit the biosynthesis of human immunodeficiency virus (HIV) by interfering with intermolecular hydrogen bonding between guanine and adenine.

N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine is a nucleoside analog that inhibits the activity of HIV reverse transcriptase. It is an antiviral agent that prevents the synthesis of viral DNA by competitively inhibiting the incorporation of deoxynucleotide triphosphates into viral DNA. This drug also has been shown to be effective against cytomegalovirus (CMV), herpes simplex virus, and varicella zoster virus (VZV). N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine has been synthesized with phosphoramidites and purified to high quality standards. The chemical structure includes a modified sugar moiety, an altered base moiety, and a unique phosphate group.

N2-Acetyl-5'-O-DMT-2'-O-methylguanosine 3'-CE phosphoramidite is an organic compound that has been modified to be an anticancer agent. It has been shown to have antiviral and antiparasitic activities. N2-Acetyl-5'-O-DMT-2'-O-methylguanosine 3'-CE phosphoramidite is a nucleoside analog, which means it substitutes for the natural ribonucleoside in DNA or RNA. The modified nucleotide prevents the incorporation of the normal nucleotide into DNA or RNA, thereby inhibiting replication. This compound also inhibits tumor growth by interfering with viral replication and inhibiting tumor angiogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite is an antiviral agent that has been shown to inhibit the replication of HIV in cell culture and to prevent the synthesis of the virus. 5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite inhibits viral replication by acting as a competitive inhibitor of HIV reverse transcriptase and blocking viral DNA synthesis from viral RNA. It has also been shown to have anticancer properties, which may be due to its ability to suppress tumor growth through inhibition of protein synthesis.

N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is a novel modified cytosine derivative. It has anticancer activity and can be used in the treatment of cancer cells that are resistant to other anticancer drugs. This product has a high purity and quality, which allows it to be widely used in the synthesis of DNA, RNA, and ribonucleosides. In addition, N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is an activator for diphosphate formation as well as a nucleotide analogue with antiviral effects. This product is also an inhibitor of DNA polymerase α and β, which are enzymes involved in DNA replication.

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-3-methyluridine 3'-CE phosphoramidite is a modified nucleoside that has antiviral and anticancer properties. It is synthesized by the reaction of 2'-O-tert-butyldimethylsilyl-5'-O-DMT (2,6-dimethoxytrityl) with 3 methyluridine. The compound has been shown to be an activator for DNA polymerase, ribonucleases and deoxyribonucleases in vitro. It also inhibits tumor cell proliferation and induces apoptosis in cultured cells. This compound is a high quality product with CAS number 179762-50-6 and is available at high purity.

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6-Thioguanosine-5'-O-monophosphate sodium salt is a nucleotide that is an endogenous purine nucleotide. It has been shown to inhibit the phosphorylation of adenosine monophosphate (AMP) by camp levels, which leads to increased cellular levels of cAMP and cyclic adenosine 3',5'-monophosphate (cAMP). 6TGMP has been shown to inhibit the growth of cancer cells in vitro, including hepatoma cells and ovcar-3 cells. This nucleotide also inhibits the activity of several growth factors, such as insulin-like growth factor 1 (IGF1), transforming growth factor beta (TGFβ), and fibroblast growth factor 2 (FGF2).

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N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite is a novel nucleoside analogue with antiviral and anticancer potential. It is a modified nucleoside that contains an acetyl group at the 4' position. The 3'-OH group has been replaced by a tertiary butyldimethylsilyl group, which renders the compound resistant to deamination by nucleases. N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite also shows high purity and high quality.

2'-C-Methylguanosine is a synthetic nucleoside analog of guanosine, modified at the 2'-carbon of the ribose sugar with a methyl group. This modification changes the molecule's biological behavior, making it potential useful in antiviral research and biochemical studies, especially those involving RNA synthesis.