Nucleosides

Guanosine 5'-[beta,gamma-imido]triphosphate tetralithium hydrate (GTP) is a nucleotide that is synthesized from guanosine 5'-diphosphate. GTP is an effector molecule that regulates the cytosolic protein synthesis and transport pathways. It binds to a number of proteins, including the guanine nucleotide-binding protein, which regulates the metabolic processes in cells. GTP has been shown to be beneficial in treating cancer by inducing apoptosis and inhibiting tumor growth. In addition, Guanosine 5'-[beta,gamma-imido]triphosphate tetralithium hydrate has been shown to inhibit congestive heart failure by reducing free radical production and increasing intracellular adenosine levels.

2-Amino-2'-deoxyadenosine 5'-triphosphate (2ADP) is a nucleotide that is involved in the synthesis of DNA. It is an important part of the process of DNA replication, as it provides the necessary energy to drive reactions that synthesize new DNA strands. It also has anti-viral properties and can be used as a molecular probe to detect acid. 2ADP is detectable with most common detection methods, such as UV/visible absorbance spectroscopy, fluorescence spectroscopy, and chemiluminescence. It is one of the three triphosphates found in cells and can be used to polymerize RNA by adding ribose phosphate groups to the sugar molecule in RNA. This reaction requires ATP, which produces AMP, ADP, and 2ADP.

2'-Deoxy-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine is a novel and synthetic nucleoside analog with antiviral activity. It inhibits the synthesis of DNA by binding to the enzyme ribonucleotide reductase. This compound has been shown to be an activator of PPARs in vitro.

2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine is a modified nucleoside analog for research applications

This low molecular DNA (deoxyribonucleic acid) from salmon sperm is a fragment that is an effective indicator of the presence of guanine in urine samples, and can be used to detect lipoperoxidation in animal hemocytes. It has also been shown to be a sublethal oxidative stress agent for human urine, which induces irreversible oxidation in the enzyme activities of signal detection. According to some recent research studies, this product is being investigated as an environmental pollutant indicator and could be used as an effective wastewater treatment method.

2’,3’-Bis-O-tert-butyldimethylsilyl-2-thiouridine is a modified nucleoside composed of 2-thiouracil (2-thiopyrimidine), a modified uracil where the oxygen at the 2-position is replaced by sulfur. Possible applications as its use as an intermediate in the chemical synthesis of RNA oligonucleotides.

3'-O-Methyluridine-5'-triphosphate lithium salt is a nucleoside that inhibits viral replication and tumor growth. It is a modified form of uridine with an extra methyl group at the 3′ position. The phosphoramidite can be used as an activating reagent for the synthesis of DNA. 3'-O-Methyluridine-5'-triphosphate lithium salt can also be used in the production of antiviral drugs, anticancer drugs, and novel compounds for research purposes.

8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate (8-AEACMP) is a structural analog of the purine nucleotide adenosine. It has been shown to be an effective inhibitor of HIV replication in vitro and in vivo. 8-AEACMP blocks HIV transcription by binding to the cellular target, the enzyme ribonucleotide reductase. This binding prevents the formation of an enzyme-substrate complex that is required for DNA synthesis. 8-AEACMP binds to two sites on this enzyme: one site is at a catalytic site that is not involved in substrate binding, and the other site is at a regulatory site. The inhibitory effect of 8-AEACMP on HIV transcription results from its ability to bind at both sites simultaneously.

2',3',5'-Tri-O-benzoyl-2-thiouridine is an analog of the nucleoside thiouracil, which is a modified nucleoside. It inhibits the synthesis of DNA and RNA by competitively inhibiting the enzyme thymidylate synthase. 2',3',5'-Tri-O-benzoyl-2-thouridine has been shown to exhibit anticancer activity in vitro and in vivo. This compound also exhibits antiviral properties against herpes simplex virus type 1 (HSV1) and Herpes simplex virus type 2 (HSV2).

2'-Deoxy-N2-DMF-5'-DMT-2'-fluoroguanosine is an anticancer agent that has been modified to contain a 2'-deoxyribonucleoside and a 5'-dimethoxytrityl (DMT) group at the 2' position. The compound inhibits DNA synthesis by binding to the enzyme DNA polymerase, thereby preventing replication. This compound is novel because it contains a deoxyribonucleoside, which is not found in any other anticancer nucleotide analogs. It also has antiviral properties against HIV, herpes simplex virus type 1, and poliovirus.

9-(2'-O-Acetyl-3'-deoxy-3'-fluoro-5'-O-toluoyl-b-D-ribofuranosyl)-6-phenylpurine (FTC) is a novel antiviral nucleoside analog that inhibits the synthesis of DNA by inhibiting the enzyme DNA polymerase. It has been shown to be effective against HIV in vitro. FTC exhibits anticancer activity through inhibition of DNA synthesis and induction of apoptosis. FTC also has high purity and quality, as it is synthesized chemically without any purification steps.

N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is a novel modified nucleoside that is an activator of ribonucleosides. It has antiviral and anticancer activities, in addition to its potential as a DNA polymerase inhibitor. N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is chemically synthesized with high purity and can be used for the synthesis of phosphoramidites for DNA synthesis. This compound also has the CAS number 12105885 3 and can be found in monophosphate form.

Uridine 5'-diphosphate choline ammonium salt is a chemical compound that contains two molecules of uridine and one molecule of choline. It is a hexamer with an empirical formula of C6H14N4O13P3. Uridine 5'-diphosphate choline ammonium salt can be found in plants and animals, as well as being synthesized by the human body. This compound is present in the interstitium, which are the spaces between cells, and may play a role in the nutritional status of humans.

4-Bromo-3,5-dichloropyridine is a reactive intermediate that is used as a reagent in organic synthesis. It has low basicity and reacts with lithium to form the lithium salt. The salt can be deprotonated to form the bromide anion, which is more reactive than the chloride anion. 4-Bromo-3,5-dichloropyridine can also be used for the selective isomerization of ketones and related compounds. Bromine is added to prevent side reactions with oxygen. The intermediates are generated at the site of reaction by using an excess of diisopropylamide over bromination agent.

β-Nicotinamide adenine dinucleotide reduced form, most commonly known as NADH, is a cofactor involved in the electron transport chain, in the metabolism of amino acids and many other cellular processes such as the synthesis of ATP. It is also a substrate for glutathione peroxidase and superoxide dismutase. The reduced form of NADH can be used as an indicator for glutathione peroxidase activity. In addition, it has been shown to have antioxidant properties by reducing reactive oxygen species (ROS) and inhibiting lipid peroxidation. This product has been used in formulations of synthetic drugs for the treatment of women with long-term effects of menopause, such as osteoporosis and cardiovascular disease. It has also been used in the production of alginate gel, which can be used to create scaffolds for tissue engineering applications. More recently, in bioorganic chemistry, NADH has been used as a source of hydride species for reduction reactions.

Thymidine 5’-triphosphate (dTTP) sodium hydrate is a fundamental building block in chemical biology. As one of the four natural deoxynucleotides, it plays a crucial role in DNA replication and repair, where dTTP is incorporated into growing DNA strands by DNA polymerases, ensuring fidelity during genetic duplication. The use of dTTP spans various applications, including PCR, DNA sequencing, and site-directed mutagenesis.

5’(R)-C-Methyluridine is a synthetic nucleoside that is an antiviral agent. It inhibits the enzyme RNA polymerase and thereby prevents the production of viral RNA. The compound can be used as a potential anticancer drug because it inhibits the synthesis of DNA in tumor cells. 5’(R)-C-Methyluridine has been shown to inhibit the growth of some bacterial species, such as Mycobacterium tuberculosis, but not other bacteria, such as Escherichia coli.

5'-Azido-2',5'-dideoxyinosine is a novel nucleoside which has been synthesized to investigate its anticancer and antiviral properties. 5'-Azido-2',5'-dideoxyinosine is an activator of ribonucleosides and deoxyribonucleosides, converting them into the corresponding monophosphate or diphosphate form. This product can be used as a building block for the synthesis of phosphoramidites and modified nucleosides. 5'-Azido-2',5'-dideoxyinosine has shown activity against cancer cells in vitro, in particular leukemia cell lines. It also has antiviral activity against HIV, herpes simplex virus type 1, and human cytomegalovirus (HCMV).

2-Amino-1-(b-D-arabinofuranosyl)-5-methyl-4(1H)-pyrimidinone (araA) is an activator of nucleoside synthesis. It is a novel and versatile chemical that can be used to produce both ribonucleosides and deoxyribonucleosides. AraA is a potent antiviral and anticancer agent that has been shown to inhibit the growth of cancer cells in vitro. AraA is a modified form of 2′,3′-dideoxyadenosine, which is synthesized by enzymatic modification of natural 2′,3′ dideoxythymidine. Rifapentine: Rifapentine is an anti-tuberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits

2’,3’,5’-Tri-O-benzoyl-5-methoxyuridine is a modified nucleoside that is structurally similar to the natural nucleoside uridine. It has antiviral properties and can be used as a monophosphate, diphosphate, or nucleotide. 2’,3’,5’-Tri-O-benzoyl-5-methoxyuridine is synthesized by reacting 5′-(triacetyl)aminoimidazole with 5′-(triisopropyl)phosphoroamidite in acetonitrile. The product has been shown to have anticancer activity in vitro and in vivo.

2,4,6-Trimethoxy-pyrimidine is a heterobicyclic compound that contains three methoxy groups. It is a synthetic nucleobase that can be found in the nucleosides uridine and cytidine, as well as in other compounds such as pyrimidines. 2,4,6-Trimethoxy-pyrimidine has been shown to be reactive to nucleophilic solutes and has been used with success in the synthesis of lactams. The isomers of this compound have different efficiencies for reaction with nucleophilic solutes.

5-Fluorouridine-5'-triphosphate sodium salt is an analog of uridine that has been used in the treatment of metastatic colorectal cancer. It is a prodrug that is metabolized to 5-fluorouracil, its active form. 5-Fluorouridine-5'-triphosphate sodium salt inhibits the synthesis of thymidylate, one of the precursors to DNA, and blocks the production of nucleotides. This results in cell lysis and death by apoptosis. The drug also inhibits epidermal growth factor receptor (EGFR), which may contribute to its antitumor effects.

7-Iodo-7-deaza-2'-C-methylguanosine has antiviral activity and is used as a building block in the synthesis of DNA and RNA molecules. 7-Iodo-7-deaza-2'-C-methylguanosine is a novel synthetic nucleoside that has anticancer properties and is used for the treatment of different types of cancer. It is also used for the prevention of viral infections, such as influenza. This product has high purity and is available in its phosphate or monophosphate form.

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-5-methyluridine is a novel nucleoside that is activated with anhydrous ammonia and then converted to the corresponding 5'-O-DMT derivative. The 2'-O-tert-butyldimethylsilyl group protects the 5'-position of the sugar moiety from attack by phosphodiesterases, allowing for its use as a substrate in DNA synthesis. The ribose moiety is also modified at the 2' position, which prevents the formation of 3',5'-cyclic monophosphate (cMP) during dephosphorylation and thereby inhibits viral replication. This nucleotide analog has been shown to be active against HIV, hepatitis B virus, and influenza A virus.

2'-Deoxyadenosine-5'-monophosphate free acid (2DAMP) is a nucleoside analogue that can be used as a fluorescent probe for detecting water vapor. 2DAMP has been shown to have cytotoxic activity against solid tumours in vitro, and may act by hydrogen bonding interactions with the active site of the enzyme form. 2DAMP is also an important cofactor in the polymerase chain reaction, and can inhibit cellular proliferation by inhibiting nuclear DNA synthesis. This drug has been used as an active antiretroviral therapy, where it inhibits HIV-1 reverse transcriptase. 2DAMP's mechanism of action involves the inhibition of p-nitrophenyl phosphate reductase (PNPPR), which is responsible for converting p-nitrophenyl phosphate into p-nitrophenol.

3'-Deoxy-3'-fluoro-5-methylcytidine is a novel monophosphate nucleoside that has antiviral activity. It is an activator of ribonucleotide reductase, which is involved in the synthesis of DNA and RNA. 3'-Deoxy-3'-fluoro-5-methylcytidine also inhibits cancer cell proliferation and enhances the effect of chemotherapy drugs used to treat cancer. 3'-Deoxy-3'-fluoro-5-methylcytidine is synthesized by coupling a modified cytosine with a phosphoramidite using standard chemical reactions. This product is available in high purity, high quality, and CAS No. 847650-07-1.

DMT-2'-OMe-pseudouridine phosphoramidite is an antiviral, anticancer, and DNA synthesis inhibitor. It has been used in the synthesis of oligonucleotide probes for sequencing and hybridization studies. DMT-2'-OMe-pseudouridine phosphoramidite is a modified nucleoside that is used as a building block for the synthesis of DNA. This compound is synthesized from 2'-deoxy-5-methyluridine and dimethoxytrityl chloride. DMT-2'-OMe-pseudouridine phosphoramidite inhibits the synthesis of RNA and DNA by binding to ribonucleotides and deoxyribonucleotides during the polymerization reaction, thereby blocking the progression of the reaction.

3'-O-DMT-thymidine is a nucleoside analogue that is synthesized from thymidine. It has been shown to bind to the proviral dna of HIV and inhibit viral replication when present in a complex with the other nucleosides. 3'-O-DMT-thymidine is also stable at high temperatures and binds to carboxamide groups on proteins. This compound has been shown to be effective as a binder for surfaces and membranes, which may be due to its ability to form stable complexes with terminal phosphates. The stability of these complexes can be influenced by the presence of denaturants such as temperature, pH, or ionic strength parameters. 3'-O-DMT-thymidine also forms stable complexes with linkers that are sensitive to thermal denaturation.

N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite is a nucleoside phosphoramidite used as a building block in the chemical synthesis of oligonucleotides containing a 2’-O-methyl adenosine nucleoside unit. The use of a chemical synthesis rather than an enzymatic one allows oligonucleotides of a desired sequence to be produced. 3’-Cyanoethyl phosphoramidites are typically used by substitution of the di-isopropylamine group with an appropriate alcohol in the presence of an azole catalyst. Oligonucleotides containing 2'-O-methylribonucleoside units have shown site-specific cleavage with E. coli RNase H, either at a hairpin loop or at a stem region.

5'-O-p-Anisoyl-2,2'-anhydrouridine is a novel nucleoside. It is an activator of ribonucleosides and deoxyribonucleosides. This compound has antiviral activity against HIV and DNA synthesis inhibitory activity against cancer cells. 5'-O-p-Anisoyl-2,2'-anhydrouridine is also a modified nucleoside that can be used for the synthesis of phosphoramidites for the chemical synthesis of oligodeoxynucleotides (ODN).

2′-O-[2-(Methylamino)-2-oxoethyl]adenosine is a nucleoside that can be used as an anticancer, antiviral, and anticoagulant. It is synthesized from the natural nucleosides adenosine and cytidine. 2′-O-[2-(Methylamino)-2-oxoethyl]adenosine has been shown to inhibit the growth of tumor cells in vitro. This compound also inhibits viral replication by inhibiting DNA synthesis through inhibition of ribonucleotide reductase and deoxyribonucleotide reductase. 2′-O-[2-(Methylamino)-2-oxoethyl]adenosine is phosphorylated by ATP to produce 2′-O-[2-(methylamino)-2-oxoethyl]adenosinophosphate (AMP). AMP then binds to the purinergic receptor P1, which leads to

2-Deoxy-2-fluoro-b-D-arabinofuranosylamine (2DF) is a monophosphate nucleoside analog that is chemically modified to form 2DF. The 2DF has shown antiviral, anticancer, and anti-inflammatory activities. It inhibits the proliferation of cancer cells by blocking the synthesis of DNA and RNA, which are necessary for cellular reproduction. This drug also has been shown to have an activator effect on diphosphate nucleotide incorporation into DNA.

Membrane-permeable brominated cAMP analog and activator of cAMP-dependent protein kinase A (PKA). In stem cell research, the compound enhanced the induction of pluripotency and efficiency of cellular reprogramming of human neonatal fibroblasts that were transduced with different transcription factors.

5'-O-DMT-2'-fluoro-2'-deoxyinosine is a novel nucleoside that has been modified with 2'-fluoro and 2'-deoxy substitutions. It is phosphoramidite, which can be activated by any of the standard methods to make DNA or RNA. 5'-O-DMT-2'-fluoro-2'-deoxyinosine is synthesized from DMT and fluoroacetyl chloride in the presence of triethylamine. This nucleoside has antiviral activity against HIV and influenza A virus, as well as anticancer effects.

5'-O-tert-Butyldimethylsilyl-2'-deoxyinosine 3'-CE phosphoramidite is a modified nucleotide that can be used as an activator for DNA synthesis. It is also a novel nucleoside with antiviral and anticancer properties. It has been shown to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in human peripheral blood lymphocytes, and it has antiangiogenic activity in vitro. The synthesis of 5'-O-tert-butyldimethylsilyl-2'-deoxyinosine 3'-CE phosphoramidite is accomplished by reacting 2'-deoxyinosine 3'-chloroethylaminophosphonate with tert-butyldimethylchlorosilane followed by treatment with triethylamine. This synthetic intermediate can then be reacted with the desired 5' phosphate group to form the final product.

Pyruvate kinase substrate

5-Iodo-2'-O-methyluridine is a novel antiviral drug that inhibits replication of DNA and RNA viruses. It is chemically synthesized from 2' deoxyuridine monophosphate, which is modified to create the 5-iodo derivative. The modification at the 5th position of the uracil ring prevents the incorporation of methylation into DNA and RNA, which can lead to cancerous growths. This compound has been shown to be an excellent activator for DNA synthesis in vitro. It has also been shown to have anticancer properties in vitro and in vivo.

Uridine diphosphate choline (UDPC) sodium is a nucleotide that is used as a phosphoramidite for DNA synthesis. The chemical formula for UDPC is C8H14N4O8P. The activation of the molecule occurs in acidic conditions, which may be due to the formation of an amide bond between the terminal phosphate and the amino group on the phosphorylcholine. This same reaction can also occur in alkaline conditions. UDPC has been shown to inhibit viral replication, including HIV-1, by blocking reverse transcription of viral RNA into DNA. It also has anticancer effects, as it inhibits cell proliferation and induces apoptosis in cancer cells. UDPC does not have any known side effects or toxicity.

6-Aza-2'-deoxy-5-methyl isocytidine is a synthetic nucleoside that is a purine analogue of cytidine. It has antiviral activity and can be used to synthesize oligonucleotides. The synthesis of 6-aza-2'-deoxy-5-methyl isocytidine starts with the removal of the methyl group from 5,6-diaminopurine to form 5-(2'-deoxy)isocytosine. This reaction can be done in two steps: first, the aminopurine ring is opened by heating it with hydrochloric acid and then reacted with sodium methoxide in methanol solution. 6-Aza-2'-deoxy-5-(2'-deoxy)isocytosine can then be converted into 6-(2'-deoxy)isocytidine by reacting it with ammonia in water or ammonium hydroxide solution.

5,6-Dihydro-5-methyluridine is a nucleoside that is found in the human genome. It is a precursor of uridine and can be used to synthesize 5-methylcytosine, which is an epigenetic modification that occurs in DNA. This modification can affect the expression of genes by changing the structure of chromatin. This drug has been identified as a potential drug target for cancer treatment and other diseases. Structural analysis has shown that this compound has a number of hydrogen bonds with oxygen atoms and hydroxyl groups, which may make it more effective than other drugs currently being studied. 5,6-Dihydro-5-methyluridine forms a phylogenetic tree with other compounds that are also found in the human genome, suggesting that it may have evolved through natural selection.

Endogenous adenosine receptor ligand; regulator of innate immunity

5'-O-DMT-N2-isobutyryl-9-(b-D-arabinofuranosyl)guanine is a nucleoside analog drug that has antiviral and anticancer properties. It is synthesized by the reaction of 5'-O-dimethoxytritylthymidine with 2,4,5,6-tetrahydropyrimidinone. This compound has been shown to be active in vitro against several viruses including herpes simplex virus type 1 (HSV1) and human immunodeficiency virus type 1 (HIV1). The antiviral activity of 5'-O-DMT-N2-isobutyrylguanine is due to inhibition of viral DNA polymerase and/or virion assembly. It also inhibits tumor cell growth in vitro.

N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite is a Ribonucleoside, Deoxyribonucleoside, Activator, Antiviral. It is a modified nucleoside with N-(acetyl)-N′-[1,2-bis(acetyloxy)ethyl]glycine esterified to the 5′ position of the ribose and 2′deoxycytidine esterified to the 3′ position of the sugar. N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite has been shown to inhibit HIV replication in vitro and in vivo. This drug also inhibits influenza A viruses and herpes simplex virus type 1 (

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-methyladenosine is a nucleoside analog. It is an antiviral and anticancer agent that inhibits the synthesis of RNA by inhibiting the DNA polymerase enzyme. N6-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-methyladenosine has been shown to be active against both DNA and RNA viruses, including herpesviruses. It has also been shown to have anti-inflammatory effects.

Nucleotide analogue for use in oligonucleotide synthesis

2'-Deoxyuridine-5'-[(a,b)-imido]diphosphate sodium salt - 10mM aqueous solution is an organic compound that is used as a plant growth regulator. It inhibits the activity of plant enzymes, such as adenylate cyclase and protein kinase C, thereby blocking the production of proteins in plants. 2'-Deoxyuridine-5'-[(a,b)-imido]diphosphate sodium salt - 10mM aqueous solution has been shown to be toxic to muscle tissue and can cause acute toxicity in mammals. However, it has been found to be safe for use on plants when diluted with water.

N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a novel nucleoside analog that is structurally related to the natural nucleotide adenosine. It is an activator of ribonucleotide reductase, which converts ribonucleosides to deoxyribonucleosides. This product has antiviral and anticancer properties. N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine can be used in research or as an intermediate for the manufacture of other pharmaceuticals.

2'-Deoxy-2',2'-difluorouridine (13C,15N) labelled is a novel and potent anticancer drug. It is an analogue of deoxyuridine with the fluorine atom replaced by a chlorine atom at the 2' position and one of the hydrogens in the uracil ring replaced by a 13C or 15N isotope. The monophosphate form of this compound is synthesized from phosphoramidites. This product is highly pure and has CAS No. 61798-00-3.

5'-Azido-N6-Boc-5'-deoxy-2',3'-O-isopropylideneadenosine is an antiviral and anticancer agent that inhibits the replication of RNA and DNA. It inhibits viral infection by inhibiting the synthesis of viral genomes, which are made up of DNA or RNA. 5'-Azido-N6-Boc-5'-deoxy-2',3'-O-isopropylideneadenosine is a novel modified nucleoside analog that blocks the incorporation of ribonucleotides into viral DNA or RNA. The drug has been shown to be effective against Hepatitis B, Hepatitis C, HIV, and other viruses. This compound can also be used as a chemotherapeutic agent for cancer treatment due to its inhibition of DNA synthesis.

O-topolin riboside-5'-monophosphate sodium salt is a phosphoramidite that has antiviral, anticancer and activator properties. It is synthesized from o-topolin riboside, which is a novel modified nucleoside. O-topolin riboside-5'-monophosphate sodium salt binds to the DNA strand and inhibits RNA synthesis. This prevents the production of proteins vital for cell division.

5'-O-p-Anisoyl-2'-O-tert-butyldimethylsilyl-5-methyluridine 3'-CE phosphoramidite is an activator of DNA synthesis. It is a novel and modified monophosphate that has been designed for the synthesis of DNA, RNA and other nucleosides. 5'-O-p-Anisoyl-2'-O-tert butyldimethylsilyl-5-methyluridine 3'-CE phosphoramidite has antiviral and anticancer properties. It can be used in the synthesis of oligonucleotides, which are short chains of nucleotides used as probes or drugs to inhibit gene expression. 5'-O-p-Anisoyl 2'-O tert butyldimethylsilyl 5 methyluridine 3' CE phosphoramidite is a high purity compound with CAS number 129225 -

Applications Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin (R414475) with similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia. References Ramasamy, K.S. et al.: J. Med. Chem., 43, 1019 (2000); Fang, C. et al.: J. Appl. Toxicol., 23, 453 (2003):

5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine is a nucleoside analog. It is synthesized by substituting the hydroxyl group of uridine with a fluorine atom and the 2' position of ribose with a 5'-O-acetyl group. This modification prevents the incorporation of this nucleoside into DNA or RNA, making it an effective antiviral and anticancer agent. 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine has been shown to be highly active against tumor cells but not normal cells in vitro.

Citicoline is a complex organic molecule, a form of B-vitamin choline that acts as an intermediate in many biosynthetic pathways, for example, in the biosynthesis of cell membrane phospholipids. As a dietary supplement, citicoline is a source of choline and cytidine, two components that are quickly absorbed in the intestine and across the blood-brain barrier. The neuroprotective properties of citicoline improves mental performance increasing the levels of other brain-related chemicals like dopamine and norepinephrine, helping with recovery in stroke patients, reducing memory loss due to aging and improving vision in patients with glaucoma.

5-Methylcytidine is a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to 5-methylcytosine. This reaction is essential for DNA replication and repair. 5-Methylcytidine has been shown to be an important factor in the regulation of mitochondrial functions, as well as other cellular processes such as protein synthesis, nuclear DNA replication, and tumor suppression. It also has been shown to inhibit the replication of murine sarcoma virus and Toll-like receptor. 5-Methylcytidine can be used in chemotherapy treatment against mouse tumors and murine sarcoma virus by preventing viral RNA synthesis with monoclonal antibodies.

2',3'-Dideoxy-5-iodocytidine is a modified nucleoside analog based on cytidine, one of the four standard nucleosides found in DNA and RNA. It has been chemically altered to interfere with DNA or RNA synthesis, making it potentially useful as an antiviral or anticancer agent.

Anti-viral; anti-neoplastic

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2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

5'-O-DMT-5-iodouridine is a nucleoside analog that fluoresces under ultraviolet light and has been used as a fluorescent probe to study nucleotide interactions. It can be used as a substitute for thymine in DNA, RNA, and other biological molecules. 5'-O-DMT-5-iodouridine is an analog of thymine that can be incorporated into DNA by mismatch repair enzymes. Structural damage to the DNA strand will cause 5'-O-DMT-5-iodouridine to fluoresce more brightly. This nucleoside analog can also act as a surrogate for thymine during chemical synthesis or enzymatic reactions.

2'-O-tert-Butyldimethylsilyl-N2-DMF-5'-O-tritylguanosine 3'-CE phosphoramidite (BTS) is a novel, modified nucleoside that has been synthesized to be used in the synthesis of DNA and RNA. This compound is an activator of ribonucleotide reductase and can be used to produce deoxyribonucleosides. BTS has shown anticancer activity in some studies and can also be used as antiviral agents. BTS also has high purity and quality, which makes it suitable for use in pharmaceuticals.

2'-Deoxycytidine is a deoxyribonucleotide that is used in the synthesis of DNA. It has been shown to have potent antitumor activity against solid tumours and may be useful for the treatment of leukemic mice. This compound has been shown to inhibit the kinase activity of IL-2 receptor and Toll-like receptor, which are proteins that regulate the immune response. 2'-Deoxycytidine also inhibits DNA polymerase activity and thermal expansion, which may make it a good candidate as an anticancer drug.

3'-Azido-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine is a synthetic nucleoside that belongs to the group of modified nucleosides. It is a phosphoramidite that has been shown to be an effective antiviral and anticancer agent. 3'-Azido-N6-benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine inhibits viral replication by interfering with DNA synthesis and repair, which is necessary for viral reproduction. The compound has also been shown to inhibit tumor cell growth in vitro and induce apoptosis in vivo.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

5'-Deoxy-5'-iodoadenosine is a nucleoside analog that inhibits the activity of the adenosine receptor. This drug binds to adenosine receptors, which are found on the surface of cells. The binding results in an inhibitory effect on viral replication and cell proliferation. 5'-Deoxy-5'-iodoadenosine has been shown to be effective against hepatitis B virus, hepatitis C virus, and human T-cell leukemia virus type 1 (HTLV-1). It is also active against animal models of human diseases such as l1210 murine leukemia and t-cell leukemia. 5'-Deoxy-5'-iodoadenosine has been shown to inhibit the growth of hl-60 cells in cell culture by blocking the synthesis of adenylate cyclase and protein kinase A.

Stavudine is a nucleoside analog that is phosphorylated by cellular enzymes to the corresponding monophosphate. Stavudine is an activator of DNA synthesis and has been shown to be effective against cancer cells in vitro. It is also active against HIV-1, which has been shown in vitro to inhibit the production of viral DNA and RNA. Stavudine's antiviral activity may be due to its ability to inhibit the synthesis of viral DNA, RNA, or both. This drug can also be used as a nucleotide precursor for oligonucleotide synthesis.

This is an activator, CAS No. is not available, Anticancer, monophosphate, Deoxyribonucleosides, Novel, Synthetic, High purity, High quality, Modified. It is a nucleoside phosphoramidite that contains a modified phosphate group at the 5' position and can be used in the synthesis of oligonucleotides or polynucleotides. This compound is also an antiviral and diphosphate.

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2'-Amino-2'-deoxycytidine is a modified nucleoside, based on cytidine. In this compound 2'-hydroxyl group has been replaced by an amino group, which can change hydrogen bonding patterns potentially affecting how it interacts with biomolecules.

2-Chloro-2'-deoxy-2'-fluoroadenosine is an antiviral agent that is used in the treatment of hepatitis B and C. It has been shown to inhibit the synthesis of diphosphate, monophosphate, and ribonucleotides. 2-Chloro-2'-deoxy-2'-fluoroadenosine also inhibits DNA synthesis and has anticancer activity. This nucleoside is a modified form of adenosine with a fluorine atom at position 2' on the ribose sugar ring.

8-Benzyloxy-N2-isobutyryl-2-deoxyguanosine is a novel, potent and selective anticancer drug that has been shown to inhibit the growth of a variety of human tumor cells in vitro and in vivo. It also has antiviral activity against herpes simplex virus type 1. The drug is an analog of 8-benzyloxyguanosine, a nucleoside which is structurally related to guanine. This compound is synthesized from the corresponding diphosphate and monophosphate derivatives by the action of DNA polymerase and DNA ligase. 8-Benzyloxy-N2-isobutyryl-2-deoxyguanosine inhibits viral replication by binding to the viral DNA polymerase and preventing further synthesis, as well as inhibiting cellular RNA synthesis.

2',3'-Dideoxyuridine-5'-O-monothiophosphate is an antiviral nucleoside that inhibits viral DNA synthesis. It is a phosphoramidate prodrug of the natural compound deoxyuridine monophosphate (dUMP). 2',3'-Dideoxyuridine-5'-O-monothiophosphate has been shown to be active against human papilloma virus and to inhibit the replication of some DNA viruses, including herpes simplex virus, cytomegalovirus, and Epstein-Barr Virus. This drug has also been shown to have anticancer activity in vitro and in vivo.

1-(β-D-Arabinofuranosyl)cytidine 5'-monophosphate (ara-CMP) is a nucleotide derivative of cytidine, specifically a nucleotide where the ribose sugar is replaced by the arabinose sugar. It's a pyrimidine nucleotide commonly known as Cytarabine 5'-monophosphate or arabinosylcytosine 5'-monophosphate.

5'-O-(4,4'-Dimethoxytrityl)adenosine is a phosphoramidite that can be used as an activator for the synthesis of DNA. It is also used in the preparation of modified nucleosides and has anticancer activity. 5'-O-(4,4'-Dimethoxytrityl)adenosine is a modified ribonucleoside with high quality and high purity. This product has been shown to have antiviral activity against HIV-1.

2'-Deoxy-5'-DMT-5-(prop-2-yn-1-ylcarbamoyl)uridine 3'-CE phosphoramidite is a diphosphate nucleoside that is used in the synthesis of DNA. It has been modified with an acetyl group at the 2' position and a propargylamine group at the 5' position. This modification improves its stability to hydrolysis by esterases and also increases binding affinity for cationic lipids. The purified material is suitable for use in a variety of DNA syntheses, including PCR amplification, gene cloning, and site-directed mutagenesis.

2'-Deoxy-N2-isobutyryl-a-cytidine (DBIC) is a modified nucleoside that is used in the synthesis of DNA. It is an activator that can be used to enhance the antitumor effects of other drugs. DBIC has been shown to inhibit the proliferation of human tumor cells by inactivating the p53 protein, which regulates cell cycle progression and suppresses tumorigenesis. This drug also has antiviral, anticancer, and anti-inflammatory properties.

8-Chloroadenosine-5'-monophosphate triethylammonium is a novel phosphoramidite that is used in the synthesis of DNA. 8-Chloroadenosine-5'-monophosphate triethylammonium has been shown to activate antiviral and anticancer drugs with high specificity. It is also used as a reagent for the synthesis of deoxyribonucleosides and nucleosides. 8-Chloroadenosine-5'-monophosphate triethylammonium has high purity and can be used in the synthesis of DNA, RNA, and other nucleosides.

b-L-2',3'-Dideoxy-5-fluorocytidine is a pyrimidine nucleoside that inhibits the deoxycytidine kinase enzyme, which catalyzes conversion of deoxycytidine to cytidine. It has potent inhibition against human lymphocytes and liver cells, as well as virus replication. b-L-2',3'-Dideoxy-5-fluorocytidine has potent antitumor activity in vitro and in vivo, with an inhibitory effect on immunodeficiency and hepatitis. This drug also has a potent inhibitory effect on T-cell growth in cell culture. b-L-2',3'-Dideoxy-5-fluorocytidine is converted to 5'-deoxyfloxuridine by cellular enzymes and then to 5'-deoxyuridylate by the enzyme uridylate kinase. The latter compound inhibits DNA synthesis by inhibiting thymidyl

Acetyl coenzyme A lithium salt is a drug that inhibits the production of acetyl-CoA, which is an important molecule in the metabolism of fatty acids. This drug has been shown to be effective against cancerous cells by inhibiting the synthesis of lysine residues and carnitine. Acetyl coenzyme A lithium salt has also been shown to inhibit the growth of typhimurium, which may be due to its ability to inhibit NADPH-cytochrome p450 reductase. Acetyl coenzyme A lithium salt has not been shown to have any carcinogenic potential in humans, but it has been shown to have carcinogenic potential in animal models.

N6-Dimethyl-3’-b-C-methyladenosine is a novel nucleoside analog that has antiviral and anticancer properties. It is a phosphoramidite, which can be used as an activator for the synthesis of modified oligonucleotides. N6-Dimethyl-3’-b-C-methyladenosine has been shown to activate ribonucleosides and deoxyribonucleosides in vitro. This compound also has anticancer properties, which may be due to its ability to act as an activator in the synthesis of DNA.

4-Amino-1-(2',3',5'-tri-O-tert-butyldimethylsilyl-b-D-ribofuranosyl)-imidazo[4,5-c]pyridine is a novel nucleoside analogue that has high purity and high quality. It is an activator of DNA synthesis, diphosphate and monophosphate of deoxyribonucleosides, ribonucleosides and analogues. 4-Amino-1-(2',3',5'-tri-O-tert-butyldimethylsilyl-b-D-ribofuranosyl)-imidazo[4,5-c]pyridine has been shown to have antiviral activities against herpes simplex virus type 1 (HSV1) in cell culture.

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2'-Deoxy-5-hydroxyuridine is a hydrated form of uracil that is used in the synthesis of nucleic acids. It is also a substrate for DNA polymerases and has been shown to inhibit the replication of herpes simplex virus. 2'-Deoxy-5-hydroxyuridine has been shown to have biological properties, such as inhibition of radiation-induced transformation, inhibition of cancer cell growth, and antiviral activity. The mechanism by which 2'-deoxy-5-hydroxyuridine inhibits the replication of herpes simplex virus is unclear but may be due to its ability to inhibit cellular metabolism.

N2-Acetyl-5'-O-DMT-guanosine is a novel anticancer nucleoside that has been synthesized to mimic the natural nucleotides found in DNA. It is phosphorylated to N2-acetyl-5'-O-DMT-guanosine monophosphate, which can be converted back to the active form of N2-acetyl-5'-O-DMT guanosine by phosphatases. This agent activates DNA synthesis and inhibits viral replication, including HIV and herpes simplex virus. The antiviral activity is due to its inhibition of viral DNA polymerase and diphosphate kinase.

2'-C-Methyl-6-S-methyl-6-thioinosine is a modified nucleoside that can be used as an antiviral and anticancer agent. It has been shown to activate the immune system by inducing cytokine production, which leads to increased cytotoxicity against tumor cells. 2'-C-Methyl-6-S-methyl-6-thioinosine has also been shown to inhibit DNA synthesis and induce apoptosis in cancer cells. This product is of high purity and quality, with a CAS number of 172722-76-8.

2'-O-Acetyl-3'-deoxy-3'-fluoro-5-methoxy-5'-O-toluoyluridine is a modified nucleoside that has antiviral, anticancer and antimalarial activities. This compound has been synthesized as a monophosphate derivative of the natural nucleoside uridine. It is an activator of DNA polymerase, which helps to synthesize DNA in cells. 2'-O-Acetyl-3'-deoxy-3'-fluoro-5-methoxy-5'-O-toluoyluridine also has anticancer activity due to its ability to inhibit the replication of the human tumor virus KSHV.

3'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine is a new antiviral nucleoside, which has been synthesized by reacting benzoyl chloride with 2'-deoxy-N2-isobutyrylguanosine monophosphate. It is also a novel DNA and RNA phosphoramidite monomer that can be used for the synthesis of oligonucleotides and oligoribonucleotides. 3'-O-Benzoyl-2'-deoxy-N2-isobutyrylguanosine is an activator of HIV reverse transcriptase, which leads to inhibition of viral replication.

5'-O-Benzoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite is a nucleoside monophosphate, which is used as a synthetic building block in DNA and RNA synthesis. 5'-O-Benzoyl-2'-O-tert-butyldimethylsilyluridine 3'-CE phosphoramidite has shown anticancer activity, which may be due to its ability to inhibit the activation of oncogenes by acting as an antagonist at the cell surface. This agent also inhibits viral replication and is active against HIV, herpes simplex virus type 1, and varicella zoster virus.

6-O-Methyl-2'-deoxyinosine is a modified nucleoside that inhibits the synthesis of DNA and RNA. It is also an anticancer agent, inhibiting the growth of tumor cells by arresting the cell cycle at the G1 phase. 6-O-Methyl-2'-deoxyinosine is a phosphoramidite for use in solid phase synthesis of oligodeoxynucleotides (ODN). This product has high purity, good quality, novel structures and excellent stability. 6-O-Methyl-2'-deoxyinosine can be used to inhibit viral replication by preventing viral DNA from being replicated into double stranded DNA. The antiviral activity of 6-O-methyl 2'-deoxyinosine against HIV has been demonstrated in vitro and in vivo using monophosphate forms.

N4-Acetyl-3'-deoxy-3'-C-methylcytidine is a novel antiviral drug that is modified from cytidine. It is an activator of the monophosphate pathway of DNA synthesis, which causes the incorporation of N4-acetyl-3'-deoxy-3'-C-methylcytidine into ribonucleosides and deoxyribonucleosides. This compound has been shown to be active against a variety of cancers, including leukemia, colon cancer, breast cancer, and prostate cancer.

6-Methylthiopurine ribonucleotide is an inhibitor that belongs to the group of analogs of betamethasone. It has been shown to have anti-cancer properties and can induce apoptosis in cancer cells. This compound has also been studied for its potential use in treating urinary tract infections, as it has been shown to inhibit the growth of bacteria such as chlorhexidine-resistant strains. Additionally, 6-Methylthiopurine ribonucleotide has been found to be a potent inhibitor of human kinase and may have therapeutic potential for a variety of diseases. This compound has also been investigated as an inhibitor of tolvaptan, which is used to treat conditions such as hyponatremia. Overall, 6-Methylthiopurine ribonucleotide shows promising potential for the treatment of various diseases and conditions.

5’-O-(4-Cyanobenzyl)-2’,3’-di-O-isopropylideneadenosine is a monophosphate nucleoside. It is a novel and modified nucleoside with antiviral and anticancer activity. 5'-O-(4-Cyanobenzyl)-2'-,3'-di-O-isopropylideneadenosine is an activator of DNA synthesis and has been shown to be effective against human papilloma virus (HPV), Epstein Barr Virus (EBV), and HIV. This compound also has high purity, CAS No. 1134156-51-6, diphosphate, Deoxyribonucleosides, Activator, High quality, Synthetic, Novel, Nucleosides, Modified that makes it suitable for use in pharmaceuticals.

5-Fluoro-4’-C-methyluridine is a novel antiviral agent that is structurally related to the nucleoside analogue cytidine. It has been shown to be an activator of DNA polymerase, which may contribute to its antiviral activity. 5-Fluoro-4’-C-methyluridine has been shown to inhibit the growth of cancer cells by modifying the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). 5-Fluoro-4’-C-methyluridine has also been shown to have anticancer effects, as it inhibits cell proliferation and induces apoptosis.

5'-O-DMT-2'-O-triisopropylsilyloxymethyl-N2-methylguanosine 3'-CE phosphoramidite is a novel monophosphate nucleotide analog of guanosine, which has been modified to include an additional methyl group on the 2' position. It exhibits antiviral activity and is a potent activator of RNA polymerase II, with a Km of ∼0.05 μM. 5'-O-DMT-2'-O-triisopropylsilyloxymethyl-N2-methylguanosine 3'-CE phosphoramidite is used in the synthesis of ribonucleosides and deoxyribonucleosides for DNA and RNA experiments. The compound has also been shown to be active against some cancers, such as leukemia, breast cancer, prostate cancer, and colon cancer. 5'-O-DMT-2'-O-

N6,5'-O-Dibenzoyl-2'-deoxy-adenosine is a monophosphate nucleoside that is used in the synthesis of DNA. It is synthesized from 2'-deoxyadenosine, which is an antiviral agent against influenza virus and anticancer agent. N6,5'-O-Dibenzoyl-2'-deoxy-adenosine has been shown to be a potent activator of the polymerase chain reaction with high purity and novel properties.

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L-Thymidine-5'-triphosphate sodium salt (L-TTP) is a modified nucleoside that is used as an anticancer agent. L-TTP is phosphorylated by ATP to form L-thymidine 5'-monophosphate (L-TMP). It also inhibits viral replication by inhibiting the synthesis of DNA and RNA, leading to cell death. L-TTP has been shown to be active against herpes simplex virus type 1, herpes simplex virus type 2, and cytomegalovirus.

9-(b-D-Ribofuranosyl)purine (9-BRP) is a purine nucleoside that is used in the synthesis of dyes. It has been shown to be an effective inhibitor of the enzyme phosphodiesterase 3B, which breaks down cyclic adenosine monophosphate (cAMP), and therefore can prevent kidney fibrosis. 9-BRP has also been shown to inhibit the synthesis of collagen by binding to cAMP. In addition, 9-BRP binds to DNA and forms hydrogen bonds with nitrogen atoms on the phosphate groups in DNA. This interaction prevents the formation of hydrogen bonds between water molecules in water vapor and phosphate groups, thus slowing down their rate of dissociation from each other. 9-BRP also has a high affinity for Toll-like receptor 4 (TLR4), which is involved in the inflammatory response, making it an ideal therapeutic candidate for treating inflammation and renal fibrosis.

2'-Deoxyguanosine monohydrate is a nucleoside that has been shown to inhibit the synthesis of DNA in human cells. It has also been shown to have a role in the regulation of energy metabolism and mitochondrial functions. 2'-Deoxyguanosine monohydrate binds to the enzyme polymerase chain reaction, which prevents the reverse transcription process from occurring. This nucleoside is involved in the biological studies of cytokine production, such as IL-2 receptor binding and calcium pantothenate-dependent activation of nuclear DNA replication.