Nucleosides

5'-O-p-Anisoyl-D3-thymidine 3'-CE phosphoramidite is a monophosphate nucleoside analog, which is an important building block for the synthesis of oligonucleotides and DNA. The material is synthesized by coupling anisoyl chloride with D3-thymidine 3'-phosphate in the presence of a base. 5'-O-p-Anisoyl-D3-thymidine 3'-CE phosphoramidite has been shown to be effective against cancer cells, as well as viral infections. It also has antiviral properties and can be used for the treatment of hepatitis C. 5′ - O - p - Anisoyl - D3 - thymidine 3′ - CE phosphoramidite CAS No.: 9341302 Molecular formula: C 22 H 26 N 4 O 10 P

2'/3'-O-(N-Methylanthraniloyl)-N6-methyl-adenosine-5'-triphosphate triethylammonium salt is a nucleoside phosphoramidite. It is modified with a methylanthranilic acid group and an aminopropyl moiety at the 2' and 3' positions of the ribose sugar moiety. It has antiviral, anticancer, and novel properties. This compound is synthesized by reacting 2',3'-O-(dimethoxytrityl) -N6-methyl-adenosine-5'-triphosphate with triethylamine in the presence of a base like pyridine or DBU.

Thymidine-5'-diphosphate trisodium salt is a novel anticancer drug that is structurally modified to resemble thymidine. It has antiviral and antitumor effects and can be used as an antineoplastic agent. Thymidine-5'-diphosphate trisodium salt is a high quality, high purity ribonucleoside that can be used in the synthesis of deoxyribonucleosides and phosphoramidites. This drug has shown activity against various types of cancer cells and is being investigated for its potential use in the treatment of leukemia.

N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite is a novel monophosphate nucleotide that can be used for the synthesis of DNA and RNA. It has antiviral, anticancer, and activating properties. N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite is synthesized by modifying cytosine with an acetyl group at the 4th position in the ribose ring, a tertiary butyldimethylsilyl group at the 2nd position on the 5' carbon atom, and a DMT group at the 5' position on the 5' carbon atom. The CAS number for this compound is 868312050.

5'-O-DMT-2'-O-hexylaminoadenosine is a modified nucleoside that has antiviral activity. It is the monophosphate form of 5'-O-DMT-2'-O-hexylaminoadenosine, and it is used in the synthesis of phosphoramidites for DNA and RNA. This nucleoside is also an activator for novel antiviral drugs.

1-Methyl-2'-O-methylinosine is a nucleoside that is naturally found in RNA. It is the methylated form of inosine, which is a nonessential amino acid and purine nucleotide. 1-Methyl-2'-O-methylinosine's chemical name is β--D--ribofuranosyl-(1'→2')--N--(6-fluoro-3-indoxyl)glycinamide monohydrochloride. This nucleoside has been researched for its potential use as an indexing tool for phylogenetic research of DNA and RNA. 1-Methyl-2'-O-methylinosine has also been shown to be structurally similar to other nucleic acids and has been classified as a nucleoside.

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite is a novel nucleotide analog that is used in the synthesis of DNA. It is an antiviral and anticancer agent that has been shown to inhibit viral replication and tumor growth. N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine 3'-CE phosphoramidite binds to the active site of the enzyme DNA polymerase, inhibiting DNA synthesis and replication. This drug has a high purity and quality as it is synthesized without any impurities.

5'-O-Acetyl-2',3'-O-isopropylideneadenosine is an anti-leishmanial agent that is synthesized from 2,3-O-isopropylideneadenosine by acetylating the 5' hydroxyl group. It was found to be more potent than the parent compound and other related compounds in inhibiting Leishmania amazonensis promastigotes. The proposed mechanism of action of 5'-O-acetyl-2',3'-O-isopropylideneadenosine involves hydrogen bonding with the guanosine moiety of DNA and inhibition of RNA synthesis. This drug also has an effect on carbonyl oxygens and resonances, which are observed in the nmr spectra. The synthetic scheme for this drug starts with uridine, which is converted to cytidine by reacting it with sodium cyanide in aqueous solution at 0°C. Cytidine

3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine is a nucleoside derivative that has antiviral activity. It is synthesized by the condensation of 2,3,5-trihydroxybenzoic acid with 3'-chloro-5'-fluoroacetophenone in the presence of pyridine and triethylamine. The nucleoside has been shown to be an effective inhibitor of HIV replication in vitro. 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine also inhibits DNA synthesis in human lymphocytes at concentrations of 5 μM or less. This compound can be used as an activator for DNA polymerases and phosphoramidites for DNA synthesis.

4-Amino-1-((2R,3R,4R,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one is a modified nucleoside that has antiviral properties. It can be used to treat HIV and hepatitis C infections. 4-Amino-1-(2R,3R4R,5R)-3-(hydroxymethyl)4-(methoxytetrahydrofuran)pyrimidine 2(1H)-one inhibits the activity of DNA polymerase by binding to its active site. This inhibition prevents the synthesis of viral DNA and deoxyribonucleosides. 4-Amino 1-(2R,3R,4R,5R)-3-(hydroxymethyl)4-(methoxytetrahydro

Potential metabolite of NADP+

Nucleoside functionalised on the base

5-azidomethyl-2-deoxyuridine (AmdU) is a nucleoside that contains an azide group. The structure of the nucleoside is similar to thymidine, and it is incorporated into nascent DNA by cellular polymerases, similarly to EdU (NE08701). Unlike EdU that needs to be further modified with azides in the presence of copper catalyst, AmdU can also react in the absence of copper catalyst using spAAC Click Chemistry with strained cycloalkynes, such as cyclooctynes. This enables detection of nascent DNA in benign, copper free conditions.

5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite is a nucleoside phosphoramidite used as a building block for the introduction of uridine units into oligonucleotides. 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite is used for a broad range of applications including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.

Used as an intermediate for the preparation of modified oligonucleotides and other cytidine derivatives containing a 2',2'-difluoro modification.

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N2,3',5'-Tri-O-acetyl-2'-deoxy-O5-diphenylcarbamoyl-a/b-guanosine is a novel nucleoside with anticancer activity. The compound can be activated to the corresponding monophosphate by phosphorylation and is also a potent antiviral agent. In addition, the compound has good chemical stability and high purity. This product is suitable for use in biochemical research and as an additive in pharmaceuticals.

3'-Azido-3'-deoxycytidine is a nucleoside analogue that is used in research. It is an analog of cytosine, with an azido group at the 3' position. 3'-Azido-3'-deoxycytidine has been shown to be effective against HIV-1 and HIV-2, although it has not been approved for use in humans. Research into the effects of this drug has demonstrated that it inhibits both DNA and RNA synthesis by interacting with nucleic acid polymerases. This leads to cell death by inhibiting the production of proteins vital for cell division.

2-Methylthio-6-chloropurine riboside is an adenosine derivative that acts as a competitive inhibitor of the enzyme RNA polymerase. It is used in the process of translation to inhibit protein synthesis. 2-Methylthio-6-chloropurine riboside is synthesized by reacting 2-methylthioadenosine with 6-chloropurine riboside and then phosphoramidite chemistry.

NPE-caged- GTP sodium salt is a novel nucleoside that can be used as a monophosphate or ribonucleotide, which is synthesized through the use of chemical phosphoramidites. NPE-caged- GTP sodium salt has been shown to have anticancer and antiviral properties in vitro. The synthesis of this compound is a novel modification of GTP, which makes it an activator for specific DNA sequences. It also has high purity and high quality.

2-Methyladenosine-5'-triphosphate (2-MeATP) is an inhibitor of the purinergic receptor P2X. It is a competitive antagonist of ATP at the P2X receptor, blocking ATP binding and inhibiting ATP-mediated signal transduction. 2-MeATP has been shown to inhibit angiotensin-mediated hyperpolarization in wild type and mutant strains of M. smegmatis, as well as m. tuberculosis perfusion in mesenteric lymph nodes and vasoconstriction in wildtype and mutant strains of AT1 receptors.

2'-Fluoro-cyclic-di-guanylate monophosphate sodium salt is a modified nucleotide that has antiviral and anticancer activities. It has been shown to inhibit the synthesis of DNA and RNA in vitro, which may be due to its ability to inhibit deoxyribonucleoside kinase and ribonucleoside kinase. 2'-Fluoro-cyclic-di-guanylate monophosphate sodium salt has also been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

1-(2'-Deoxy-3',5'-di-O-toluoyl-a-D-ribofuranosyl)-4-amino-1,2-dihydro-2-oxo-1,3,5-triazine is a nucleoside derivative that features a modified pyrimidinone (triazine) base attached to a protected deoxyribose sugar. This molecule can be used in research.

4-Amino-3-(1-naphthylmethyl)-1H-pyrazolo[3,4-d]pyrimidine-1-(b-D-ribofuranosyl-5'-triphosphate) is a nucleoside that inhibits the growth of cancer cells. It has been shown to inhibit the growth of leukemia and lymphoma cells in vitro. This compound is active against herpes simplex virus type 1 (HSV1) and has antiviral properties. The chemical synthesis of 4-amino-(1HNMPP) is novel and should provide high purity and quality products.

N4-Acetylcytidine is a modified nucleoside and endogenous urinary nucleoside product of the degradation of tRNA. N4-Acetylcytidine is a biological marker for various cancers with elevated concentrations present in urine. N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine.

N6-Benzoyl-5'-O-DMT-2'-O-propynyladenosine 3'-CE phosphoramidite is a modified nucleoside, which is an important building block for DNA and RNA synthesis. It is synthesized by the condensation of 6-benzoyladenosine with 2'-O-propynyladenosin. The stability of this compound has been demonstrated by its resistance to hydrolysis and oxidation, while it can also be activated with a variety of activators, including NaBH4 or NaCNBH3. This novel nucleotide has shown anticancer activity in vivo and antiviral activity against HIV.

8-(4-Amino-(2',3',4',5',6'-D5-biphenyl)-2'-deoxyguanosine is a novel, diphosphate nucleoside with antiviral and anticancer activity. It has been shown to activate the transcription of genes that are involved in cell growth and differentiation. This drug also inhibits the synthesis of viral DNA by binding to the viral DNA polymerase, thereby inhibiting its function. 8-(4-Amino-(2',3',4',5',6'-D5-biphenyl)-2'-deoxyguanosine can be used as a phosphoramidite for the preparation of oligonucleotides for use in gene therapy.

8-Allyloxy-9-(b-D-xylofuranosyl)guanine is a novel nucleoside that is an activator of ribonucleotide reductase. It is a deoxyribonucleoside and monophosphate, and it has been shown to be active against cancer cells and viruses. 8-Allyloxy-9-(b-D-xylofuranosyl)guanine inhibits the growth of cancer cells by inhibiting DNA synthesis and protein synthesis, which may be due to its inhibition of ribonucleotide reductase. This drug also has antiviral activity against HIV, herpes simplex virus type 1 (HSV1), and herpes simplex virus type 2 (HSV2).

Orotidine is a decarboxylase inhibitor. It inhibits the enzyme that converts orotate to uridine and the enzyme that converts orotate to decarboxylase. Orotidine has been shown to inhibit the growth of opportunistic fungal organisms and may be useful in treating infections caused by these pathogens. Orotidine is an analytical method for measuring the activity of orotidase, which catalyzes conversion of orotate to uridine. The enzyme form of orotidase found in human erythrocytes is very sensitive to inhibition by picolinic acid, which is used as a substrate for this reaction.

Lauroyl CoA is a body-fat molecule that can be formed from acetyl-coenzyme A, which is an intermediate in the metabolism of fatty acids. It is used in analysis as a standard for enzyme activities and as a substrate for reactions involving enzymes with coenzyme A. Reaction mechanisms are determined using titration calorimetry and structural analyses are performed using analytical methods such as infrared spectroscopy and nuclear magnetic resonance spectroscopy. Lauroyl CoA is also used to study the effects of the protein toll-like receptor 4 on hepatic steatosis. The wild-type strain of Escherichia coli was used to measure the activity of bacterial synthetases containing lauroyl CoA.

3'-O-Allylcytidine is a phosphoramidite nucleoside that is synthesized by the coupling of cytidine with allyl bromoacetate. It has antiviral activity, and has been shown to be active against herpes simplex virus type 1 (HSV-1) and hepatitis B virus (HBV). 3'-O-Allylcytidine has also been shown to inhibit the growth of cells in culture, suggesting that it may have anticancer properties. 3'-O-Allylcytidine is a novel monophosphate nucleoside that has not been previously reported.br>

2'-Deoxy-5'-DMT-5-[3-(trifluoroacetylamino)-1-E-propenyl]-uridine 3-CE phosphoramidite is a synthetic nucleoside analog that has been modified to contain a triphosphate group. It is used in the synthesis of DNA or RNA. The compound is synthesized from 2,4-dichloro-N-(2,6-dimethoxybenzyl)phenylamine, which was reacted with ethyl (3-[(trifluoroacetyl)amino]propanoate) and deoxythymidine 3'-monophosphate. The CAS number for this product is 851520-76-8.

a morpholino amidite

9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-CE phosphoramidite is a novel nucleoside analogue that has shown to be effective against cancer. This product can also be used as an antiviral and antifungal agent. It is synthesized from 2,3,4,5,6-pentaacetoxybenzaldehyde and chloroacetamide. 9-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'-CE phosphoramidite is a high quality product that is made of Ribonuclesides, Synthetic Monophosphate Nucleosides Diphosphate Modified Deoxyribonucleosides Activator.

Acetoacetyl coenzyme A trisodium salt tetrahydrate is a novel antiviral agent that inhibits the synthesis of viral DNA and RNA. Acetoacetyl CoA has been shown to inhibit the replication of HIV, HSV-1 and HSV-2, influenza virus, and cytomegalovirus (CMV). The mechanism of action is not yet known but may be related to its ability to activate cellular DNA polymerase β. Acetoacetyl CoA also has a high purity and quality, as well as being modified for use in phosphoramidites.

5-Fluoro-6-iodouridine is a nucleoside that is used as the starting material for synthesizing fluorinated pyrimidine derivatives, which are used in cancer treatment. 5-Fluoro-6-iodouridine is an activator of ribonucleotide reductase and can be used to inhibit the growth of tumor cells. 5-Fluoro-6-iodouridine has been shown to inhibit the proliferation of human leukemia cells in culture, with cytotoxicity that was comparable to that of 5-fluorouracil.

Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides. N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite, also known as 2'-fluoro-dA CEP, is a modified adenosine with a fluorine atom in the 2’ position to enable the synthesis of non-natural fluorine containing oligonucleotides. Nucleoside phosphoramidites are typically modified by displacement of the diisopropylamine group with the 5’ hydroxyl of the next nucleoside in the presence of an azole catalyst such as 1H-tetrazole or 4,5-dicyanoimidazole. 2'-Fluoro-dA CEP has been used in the synthesis of phosphorothioate oligonucleotides that were highly nuclease resistant yet retained exceptional binding affinity to the RNA targets.

2-Chloro-4-hydroxy-5-fluoropyrimidine is a nucleoside with antiviral and anticancer activity. It has shown to be an effective agent against HIV, herpes virus and human papilloma virus. 2-Chloro-4-hydroxy-5-fluoropyrimidine inhibits the synthesis of DNA by inhibiting the enzyme DNA polymerase, which catalyzes the formation of diphosphate from monophosphate. In addition, it inhibits protein synthesis by inhibiting ribonucleotide reductase, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides.

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5'-O-Acetyladenosine is a labile nucleoside that can be converted to adenosine. It is a substrate for the enzyme ribonucleotide reductase, which converts it to adenosine monophosphate. 5'-O-Acetyladenosine has been shown to function as an equilibrating agent in the synthesis of guanosine and other pyrimidine nucleotides. In addition, it is a precursor for the synthesis of purines. 5'-O-Acetyladenosine can be synthesized from trimethyl phosphate and chloride gas yields acetaldehyde, which then reacts with phosphorus oxychloride to form 5'-O-acetyladeninol, which undergoes hydrolysis to yield 5'-O-acetyladenosine. The regioselectivity of this reaction depends on the concentration of reactants and solvents used in the reaction.

5'-Deoxy-5'-iodothymidine is an antiviral nucleoside that inhibits viral replication by competing with the natural substrate, deoxyribonucleotide triphosphate, for incorporation in DNA. 5'-Deoxy-5'-iodothymidine has been shown to be a novel antiviral agent and an activator of host immune responses against virus infections. 5'-Deoxy-5'-iodothymidine is also used as an intermediate for the synthesis of phosphoramidites, which are used in the production of DNA.

Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is a high purity chemical substance. It is an antiviral and anticancer agent, which has been shown to inhibit the replication of DNA in vitro. Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid can be used for the synthesis of ribonucleosides, deoxyribonucleosides, nucleoside phosphoramidites, diphosphate and triphosphate. This novel chemical substance is also a potential inhibitor of DNA polymerase and RNA polymerase.

5-Chlorocytidine is a reactive oxygen species that can be generated by the hypochlorous acid (HOCl) or by atp, which is a nucleotide. 5-Chlorocytidine has been shown to induce apoptosis in virus-infected mammalian cells and macrophage-like cells. It also induces pro-inflammatory cytokines and has potential as a biomarker for leukemia and inflammatory diseases. 5-Chlorocytidine reacts with proteins and lipids in the atherosclerotic lesion to produce other reactive oxygen species, such as hydrogen peroxide, which may lead to cell death.

2'-Deoxyguanosine 3'-monophosphate sodium is a novel, synthetic nucleoside that inhibits DNA replication and transcription. It has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I). 2'-Deoxyguanosine 3'-monophosphate sodium is in the category of nucleosides, which are phosphorylated compounds that can be incorporated into DNA by DNA polymerase. This product has a high purity and is synthesized from diphosphate.

Benzyl-N, N-diisopropylchlorophosphoramidite is a novel nucleoside phosphoramidite with anticancer activity. It is synthesized from benzyl alcohol and diisopropylamine by reaction with phosphorus oxychloride in the presence of a base. This compound can be used to activate DNA for subsequent coupling reactions or for modification of DNA. Benzyl-N, N-diisopropylchlorophosphoramidite has been shown to have antiviral and antitumour activities in vitro and in vivo.

2'-Deoxy-2'-fluorocytidine-5'-triphosphate sodium, 100mM aqueous solution is a nucleoside analog that is modified at both the 2' position of the sugar (deoxyribose) with a fluoro group and the 5' position with a triphosphate group. This compound is an important tool in biochemistry, molecular biology, and drug development, particularly for studying nucleic acid synthesis and genetic processes.

Thymidine 5’-triphosphate tetralithium salt (dTTP) is a crucial component in chemical biology research. It is a modified form of thymidine, containing three phosphate groups. Important in DNA replication and repair, dTTP acts as a substrate for DNA polymerases during polymerase chain reactions (PCR), facilitating the amplification of specific DNA sequences. In addition, in DNA sequencing, dTTP is incorporated into newly synthesized DNA strands, allowing precise determination of nucleotide sequences.

RSPACER CEP is a novel synthetic oligonucleotide with anti-cancer and antiviral activity. The product has been shown to inhibit the proliferation of tumor cells in vitro and reduce the production of pro-inflammatory cytokines in macrophages. The product is phosphoramidite, which is an intermediate for the chemical synthesis of DNA. It is synthesized from deoxyribonucleosides, modified nucleosides, and monophosphate nucleotides. RSPACER CEP also has antiviral properties that are mediated by inhibiting viral RNA replication in infected cells through inhibition of viral polymerase.

U-13C10, U-[15N2]-mono-Labelled Thymidylyl-3'-5'-thymidine ammonium (compound A) is a novel anticancer drug that is synthesized by phosphoramidite chemistry. It is an activator of DNA synthesis and has been shown to be cytotoxic against cancer cells in vitro. This compound is also a high quality nucleoside analogue. The molecular weight of this compound is 434.4 g/mol and it has a CAS number of 81633-09-9.

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine is a synthetic nucleoside that is used in the synthesis of RNA. It has been shown to be resistant to heat and both acidic and basic conditions. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine can be used for modifications of oligonucleotides and as a convenient sealant for the synthesis of DNA, RNA, or other nucleic acids. This product is neutralized with hydrochloric acid prior to use.

2’-C-Methyl-5-methoxyuridine is a nucleoside analog that inhibits viral replication by inhibiting DNA synthesis. It is also used in the treatment of cancer, as it inhibits the growth of tumor cells by altering their genetic material. This drug is a phosphorothioate and can be activated with an activator to form its active form, which is incorporated into DNA during replication. 2’-C-Methyl-5-methoxyuridine has been shown to be effective against many viruses, including human immunodeficiency virus (HIV), herpes simplex virus type 1 (HSV1), and herpes simplex virus type 2 (HSV2). This drug has been shown to cause death of tumor cells via apoptosis or cell cycle arrest at the G0/G1 phase.

Adenosine 3'-monophosphate sodium is a nucleotide that is used as a substrate for enzymes. It has been shown to increase the enzymatic activity of papaverine, litoralis, subtilis, and histidine phosphatase. Adenosine 3'-monophosphate sodium also has protease activity, which can be activated by adding an enzyme preparation containing subtilisin and trypsin. This compound also has a pH optimum of 8.0-9.5 and is active at an alkaline pH of 9.5-10.5. The specific strain of bacteria will determine the optimal pH range for activity, with enterobacter bacterial strains having a maximum range of 6-7 and brevibacterium bacteria strains having a range of 4-6.

Poly(2'-Fluoro-2'-Deoxyadenylic Acid) (PFDAA) is a synthetic analog of natural RNA polymerase II α subunit. It has been shown to be a potent inhibitor of protein synthesis in vitro, with an IC50 of 1 μM. PFDAA has been used as a primer in PCR reactions and as a template for transcription reactions. In these reactions, PFDAA was able to phosphorylate the β-subunit of RNA polymerase II and to induce transcriptase activity, but not DNA replication. The divalent cation requirement for this reaction may be due to the formation of a ternary complex with the template strand and ATP.

5-Formylcytidine is a nucleoside that belongs to the group of pyrimidine nucleosides. It is structurally similar to cytidine, but with a formyl group in place of the hydroxymethyl group on the C5 position. 5-Formylcytidine has been shown to have an inhibitory effect on mitochondrial protein synthesis and cellular functions in mammalian cells.

N6-Benzoyl-3'-O-methyladenosine is a novel modified nucleoside that has antiviral activity. It has been shown to possess high purity and high quality, and can be used as an activator for DNA synthesis. N6-Benzoyl-3'-O-methyladenosine is synthesized from 3'-O-methyladenosine with the use of phosphoramidites, ribonucleosides, or monophosphate nucleotides. The compound is CAS No. 85090-30-8 and is soluble in water.

Uridylyl-3'-5'-cytidine ammonium salt is a monophosphate of cytidine. It is an antiviral agent that inhibits the replication of human immunodeficiency virus type 1 (HIV-1). Uridylyl-3'-5'-cytidine ammonium salt is synthesized by the reaction of uridyl 3'-5' -adenosine monophosphate with cytidine. This compound has been shown to be effective in inhibiting the proliferation of cancer cells. Uridylyl-3'-5'-cytidine ammonium salt has shown activity against a variety of cancers, including breast, lung, and colon cancers.

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxyadenosine is an antiviral, monophosphate nucleoside that has been shown to inhibit the proliferation of human leukemia cells. The compound is a novel synthetic nucleoside that inhibits the viral reverse transcriptase enzyme and prevents RNA synthesis. N6-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxyadenosine also inhibits DNA synthesis by inhibiting the activity of DNA polymerases and can be used for the treatment of cancer.

2',3',5'-Tris-O-[tert-butyldimethylsilyl]-2-chloroadenosine is a phosphoramidite that can be used in the synthesis of ribonucleosides, deoxyribonucleosides, and nucleoside analogues. It is a novel compound that has antiviral and anticancer properties. This product is synthesized from 2,3,5-trichloropyrimidine by reaction with tert-butyldimethylsilyl chloride in the presence of triethylamine. The product is purified by vacuum distillation and characterized using proton nuclear magnetic resonance (NMR) spectroscopy.

3-Methyl-2-nitropyridine is a high yield byproduct of formamide, which can be activated to form an intermediate for the synthesis of nucleosides. The kinetics and labeling of this intermediate were studied using a transfer experiment. 3-Methyl-2-nitropyridine is acidic, with a pKa value of 3.6, and is reactive towards nucleophiles. It is also catalytic, yielding methyl groups and dioxane as products when heated at temperatures between 180°C and 220°C. In addition, it undergoes nucleophilic substitutions at methoxy groups.

2'-Azido-N6-benzoyl-2'-deoxy-5'-O-DMT-adenosine is a novel nucleoside that can be activated with phosphoramidite and used to synthesize a variety of modified nucleosides. It has been shown to have anticancer and antiviral activities, as well as the ability to inhibit the replication of RNA viruses. 2'-Azido-N6-benzoyl-2'-deoxy-5'-O-DMT-adenosine is also useful in the synthesis of monophosphate nucleotides, which are important for DNA synthesis. This product is available in high purity and quality and is CAS No.

3'-Deoxythymidine (3DT) is a nucleoside analog that has high resistance to HIV. It is an analogue of the human insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptor and inhibits the binding of IGF-1 to its receptor, thereby inhibiting the growth of cells. 3DT has been shown to have a protective effect against radiation in mice, with an LD50 at a dose of 5.0 mg/kg for radiation exposure. 3DT also has antiviral activity against murine sarcoma virus, as well as other biological properties such as enzyme activities and disease activity. This drug may be used in future research on polymerase chain reactions (PCRs) and DNA sequencing, since it is chemically stable and can be easily synthesized.

2'-Deoxy-2'-fluoroinosine 5'-monophosphate lithium salt is a nucleoside analog that has been modified to contain a fluorine atom at the 2' position of the ribose sugar. This agent is an activator of DNA polymerase and can be used in the synthesis of oligonucleotides. It is also an antiviral and anticancer agent.

6-O-Methylinosine is a modified nucleoside that is used in the synthesis of recombinant proteins. It is synthesized from the reaction of methylphosphate and 6-O-methylguanosine. The phosphate group of the 6-O-methylguanosine molecule reacts with methylphosphate in an acid or neutral environment, while it reacts with phosphoric acid in a basic environment. This reaction can be monitored by measuring the amount of free phosphate groups present after the reaction. The rate of this reaction can be increased by increasing temperature and pH. 6-O-Methylinosine has been shown to have anticancer activity, which may be due to its ability to inhibit enzyme catalysis and modify DNA structure.

2'-Deoxy-8-(9H-fluoren-2-ylamino)-guanosine (FdA) is a synthetic nucleoside that was designed for use as a dietary supplement to inhibit carcinogenesis. It is an analog of guanosine and is phosphorylated by cellular kinases to form 2'-deoxy-8-(9H-fluoren-2-ylamino)-inosine monophosphate. FdA inhibits the process of DNA replication in mammalian cells, which may be due to its ability to bind single stranded DNA. This drug has been shown to reduce the mutation frequency and increase the life span of mice with bladder cancer.

2',3'-Dideoxy-6-thio-inosine is a nucleoside analog that is used in vitro for the investigation of viral replication. 2',3'-Dideoxy-6-thio-inosine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) infection, and has been shown to inhibit the synthesis of viral dna. The in vitro activity of this drug against HIV has been shown to be greater than 200 times more potent than zidovudine or didanosine. 2',3'-Dideoxy-6-thio-inosine also inhibits the growth of some cell lines, including those derived from infected T cells, indicating that it may have cytocidal effects.

N6-Benzoyl-7-deaza-2'-deoxy-5'-O-DMT-7-iodoadenosine is a modified nucleoside that is used as an antiviral and anticancer agent. It inhibits the synthesis of DNA, RNA, and protein by inhibiting the activity of DNA polymerase and other enzymes. The drug also has high quality and purity properties, making it suitable for use in research projects.

2-(2-Furyl)-5-pyrimidinecarbaldehyde (2FP) is a novel anticancer activator that belongs to the class of modified DNA. 2FP is a nucleoside analogue that inhibits the synthesis of DNA, RNA, and protein. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. This compound may be used as an antiviral agent against HIV and herpes virus infections. 2FP has high purity and quality, with CAS number 959240-19-8.

3'-Amino-2',3'-dideoxyadenosine's lack of a 3'-hydroxyl group makes it a chain terminator for DNA polymerase, a key application in Sanger sequencing. Additionally, the 3'-amino group serves as a functional handle for modifying the 3' end of oligonucleotides with various labels or conjugates, expanding their utility in research and diagnostics.

7-Deaza-3'-deoxyadenosine is a synthetic nucleoside that is used in the synthesis of DNA. It has antiviral activity and is effective against HIV, herpes simplex virus and hepatitis B. 7-Deaza-3'-deoxyadenosine also has anticancer activity and can be used as a chemotherapeutic agent for leukemia, lymphoma, and breast cancer. This drug has been shown to inhibit the growth of cultured human tumor cells by inhibiting DNA synthesis through inhibition of DNA polymerase alpha and beta.

4-(Isobutylamino)-2-(Methylthio)Pyrimidine-5-Carboxylic Acid is a nucleoside analogue that inhibits viral replication by acting as an antiviral agent. It blocks the enzymatic activity of DNA polymerases, including reverse transcriptase, and prevents the synthesis of new viral DNA. 4-(Isobutylamino)-2-(Methylthio)Pyrimidine-5-Carboxylic Acid is also an activator for HIV integrase, which is an enzyme that integrates HIV DNA into the host genome. This compound has been shown to be effective against HIV and herpes viruses in vitro.

The 4-Amino-6-hydroxy-2-mercapto-5-nitrosopyrimidine ammonium salt is a solvent that has been used in the synthesis of various organic and inorganic compounds. It is a five membered ring compound with solvents, such as chlorides, and it can be found in diffraction patterns. 4-Amino-6-hydroxy-2-mercapto-5 nitrosopyrimidine ammonium salt can also act as a ligand in metal complexes. The molecule has carbonyl groups which chelate to the metal atom and form a ring with chlorine atoms.

2-Methylthio-6-chloro-9-methylpurine is an activator that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA and RNA. 2-Methylthio-6-chloro-9-methylpurine has been shown to inhibit viral replication and may be used as a antiviral agent. This compound has novel properties and is a potential anticancer drug due to its ability to inhibit the growth of tumor cells.

3',5'-Diamino-3',5'-dideoxythymidine (ddT) is a cytosine analog that inhibits the growth of cells by interfering with DNA replication. This drug is effective against viruses such as herpes, which are dependent on deoxycytidine for replication. 3',5'-Diamino-3',5'-dideoxythymidine binds to the viral DNA and prevents it from being used as a template for viral RNA synthesis. It also has potent antiviral activity against l1210 and uninfected mice. 3',5'-Diamino-3',5'-dideoxythymidine is not charged and does not penetrate tissues well because of its large size. It also has limited effects on bacterial enzymes.

2'-Deoxy-4-thiouridine is a pyrimidine nucleoside for a range of applications

2'-Deoxy-5-hydroxyuridine 5'-triphosphate (doxorubicin) is a cytotoxic and chemotherapeutic agent that interferes with DNA replication. It is an oxidized form of the natural pyrimidine base thymine. The drug blocks DNA synthesis by preventing the incorporation of uracil into the newly synthesized strand, which causes strand breaks. Doxorubicin has been shown to be effective in treating a variety of cancers, including those of the breast, ovaries, bladder, and stomach. This drug can also cause severe side effects such as heart damage and hearing loss due to its interaction with cellular oxygen metabolism.

2'-Deoxy-5'-O-DMT-5-(methylthio)-uridine 3'-CE phosphoramidite is a novel anticancer agent that inhibits DNA synthesis and RNA transcription. It is a nucleoside analog, which is not metabolized by the body, and can therefore be used in combination with other drugs to treat cancer. This drug has been shown to be active against influenza virus and herpes simplex virus, as well as inhibiting the production of HIV. 2'-Deoxy-5'-O-DMT-5-(methylthio)-uridine 3'-CE phosphoramidite has also been shown to inhibit the growth of tumor cells when combined with other chemotherapeutic agents.

5-Bromo-2'-deoxyuridine 5'-diphosphate sodium salt - 10mM aqueous solution is a monophosphate nucleoside and an antiviral agent that inhibits viral DNA synthesis by inhibiting the activity of ribonucleotide reductase. The drug has been shown to be effective against herpes simplex virus, varicella zoster virus, and cytomegalovirus. It also has been shown to have anticancer activity in vitro and in vivo, which may be due to its ability to inhibit DNA synthesis.

Thymidine-3',5'-tetrabenzyldiphosphate is a monophosphate analog of thymidine. It has been used as a building block for the synthesis of DNA, RNA, and phosphoramidites. Thymidine-3',5'-tetrabenzyldiphosphate is a novel nucleoside compound that has been shown to have anticancer and antiviral activities. This product is intended for research purposes only.

1-(8-Phosphonooctyl)-7-deazaxanthine is an organic compound that inhibits endothelial cell growth. It has been shown to inhibit the phosphorylation of intracellular proteins, leading to a reduction in the activity of tyrosine kinases and protein kinase C. 1-(8-Phosphonooctyl)-7-deazaxanthine is also a noncompetitive inhibitor of phosphonate metabolism, with an inhibitory potency of 0.1 μM. This compound has been shown to be an anticancer agent in vitro and in vivo, but not as potent as other known drugs such as doxorubicin or cisplatin.

5'-O-Tritylthymidine 3'-CE phosphoramidite is a synthetic, modified nucleoside. It is an ester of thymidine and trityl chloride. 5'-O-Tritylthymidine 3'-CE phosphoramidite is used as an anticancer drug and has been shown to activate the transcription of ribonucleic acid (RNA) in vitro, which may be due to inhibition of the enzyme RNA polymerase II. This product has also been shown to have antitumour activity against human colon and ovarian cancer cells in vivo.

N6-Methyl-2'-C-methyladenosine is a modified nucleoside that belongs to the category of Deoxyribonucleosides. It is a novel compound with antiviral, anticancer, and antitumor properties. N6-Methyl-2'-C-methyladenosine inhibits viral replication by blocking the synthesis of DNA. This compound also has antiproliferative effects on cancer cells and retards tumor growth in animal models. N6-Methyl-2'-C-methyladenosine is synthesized from phosphoramidites in a two step process: first, the addition of methyl iodide to the phosphorus atom followed by nucleophilic substitution with methylamine.

3-Deazaguanosine is a nucleotide that is found in uridine, which is present in the nucleic acids of all cells. It has been shown to be cytotoxic to colorectal adenocarcinoma and carcinoma cell lines, and this cytotoxicity may be due to its ability to inhibit energy metabolism. 3-Deazaguanosine has also been shown to significantly inhibit viral replication, including HIV and herpes simplex virus type 1. It binds with high affinity to monoclonal antibodies that are specific for nucleotide levels. 3-Deazaguanosine inhibits tissue culture enzyme activity and can cause significant changes in adenine nucleotide levels in cell culture.

7-(Aminomethyl)-7-deazaadenosine is a nucleoside that has antiviral and anticancer properties. It is a novel compound, and its synthesis involves the use of activated 2′-deoxyribonucleosides. This compound is synthesized by reacting 7-amino-7-deazaguanine with an appropriate phosphoramidite at room temperature in the presence of an activator such as ammonium hydroxide or pyridine. The product can be purified by recrystallization from methanol, followed by chromatography on silica gel using a gradient elution system. The purity of this compound can be determined by HPLC analysis with UV detection at 254 nm. br>br>

2'-Deoxy-5'-O-DMT-guanosine is a purine nucleoside that is converted to 2'-deoxy-5'-O-DMT-adenosine by the enzyme deoxyadenosyltransferase. This conversion is necessary for the synthesis of adenosylcobalamin, which is essential for the methylation of homocysteine to methionine. 2'-Deoxy-5'-O-DMT-guanosine has been shown to have cancer chemopreventive effects in vitro and in vivo. It also has been shown to enhance dna hybridization and hydrophobic interactions with cancerous cells, which may be due to its ability to inhibit gene expression.

Agonist of P2Y6 purinoceptor; antagonist of P2Y14

2'-Deoxy-5'-O-DMT-guanosine-(iBu)-succinyl CPG 1400 Å is an antiviral, anticancer, and high purity monophosphate of 2'-deoxy-5'-O-DMT-guanosine. It is a novel nucleoside with a modified phosphate group. This product can be used to synthesize DNA and RNA, as well as in the treatment of cancer.

N4-Acetyl-2'-deoxy-5'-O-DMT-5-iodocytidine is a synthetic nucleoside that has antiviral and anticancer properties. It is an activator of deoxyribonucleosides and can be used to synthesize DNA, RNA, or other modified nucleosides. This compound is modified with acetyl groups at the 2' position and 5' position of the ribose sugar to increase its stability in biological systems. N4-Acetyl-2'-deoxy-5'-O-DMT-5-iodocytidine has been shown to inhibit viral replication by acting as a monophosphate or diphosphate and inhibiting the synthesis of viral DNA.