Nucleosides

5-Formyl-2'-O-methylcytidine is a molecule that is involved in cellular processes such as DNA methylation, the addition of a methyl group to the 5 position of a cytosine residue. It has been shown to be an important epigenetic regulator and can be used as a strategy to treat tuberculosis. 5-Formyl-2'-O-methylcytidine is synthesized from guanine, which undergoes conversion into cytosine via enzymatic modification. This process is catalyzed by methyltransferase enzymes and it is usually carried out with S-adenosylmethionine (SAM) as the methyl donor. The product then converts back into guanine through deamination, which can be catalyzed by either adenine phosphoribosyltransferase or adenylate kinase.

2'-Bromo-2'-deoxyuridine is a synthetic nucleoside analog of deoxyuridine, in which the 2'-hydroxyl group of the ribose sugar is replaced with a bromine atom (Br) at the 2' position. This modification allows it to be incorporated into DNA during DNA synthesis, where it can replace the normal thymidine. This molecule can potentially be used in molecular biology and cell biology as a thymidine analog to study DNA replication, cell proliferation, and DNA repair.

aATP is useful in molecular biology applications including PCR/qPCR, reverse transcription, DNA labelling and DNA sequencing.

Second messenger in intracellular signal transduction

7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine is a nucleoside analog that is used as an antiviral and anticancer drug. It has also been shown to have antimalarial activity. 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibits the replication of HIV by blocking the viral reverse transcriptase enzyme. This drug is a phosphoramidite monophosphate with a purity of 99%.

Anti-viral; reverse transcriptase inhibitor

2'-O-Me-5'-O-DMT-1,3-di-N-POM-pseudouridine-3'-CE phosphoramidite is an antiviral agent that inhibits the synthesis of RNA. It has been shown to inhibit the production of new viruses in cultured cells and to be active against some strains of influenza virus. The modification was developed by chemists at Boehringer Ingelheim, who have also synthesised other novel nucleosides that are being tested as anticancer agents. This product is a monophosphate derivative with a high purity level and a CAS number.

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-(p-nitrophenylcarbonyloxy)uridine is a novel phosphoramidite. It is modified with p-nitrophenyl carbonyloxy group at the 3' position of the uracil moiety. This phosphoramidite has antiviral activity against Hepatitis C and HIV. It also has anticancer activity in vitro and in vivo. 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-(p-nitrophenylcarbonyloxy)uridine is a nucleoside that can be used for DNA synthesis or as a monophosphate or diphosphate for RNA synthesis. It is synthesized from deoxy

Cytidine hemisulfate salt is a postulated inhibitor of the blood group antigen. It inhibits the phosphatase activity of blood group-specific phosphatases, which may be caused by its specific inhibition of α-tocopherol and phenolphthalein. Cytidine hemisulfate salt has been shown to inhibit both adenylic and uridylic phosphatases, but does not inhibit other phosphatases. This drug is also an antigen that can stimulate B cells, which produce antibodies against it. Cytidine hemisulfate salt is found in DNA and RNA.

A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.

3'-Azido-3'-deoxy-5-fluorocytidine is an activator with novel antiviral and anticancer properties. It is a high quality, modified nucleoside that can be used to synthesize deoxyribonucleosides and ribonucleosides. 3'-Azido-3'-deoxy-5-fluorocytidine has been shown to inhibit the growth of cancer cells in vitro and in vivo.

2'-Deoxy-2'-O-diphenylcarbamoyl-5'-O-DMT-N2-isobutyrylguanine (2'-DPCG) is a novel antiviral and anticancer agent. It has been shown to inhibit the replication of both DNA and RNA viruses. 2'-DPCG is synthesized in a high yield and purified to near homogeneity. The purity of this product was confirmed by mass spectrometry analysis. The CAS number for this product is 1227071-12-0.

2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a nucleoside that is used in the synthesis of DNA. It is an antiviral and anticancer agent that has been shown to have anti-inflammatory properties. 2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite inhibits viral replication by inhibiting the synthesis of viral RNA, which prevents the production of proteins necessary for viral reproduction. The modified monophosphate form of this nucleoside is also a potent inhibitor of cancer cells in vitro and in vivo.

2'-O-(2-Methoxyethyl)-5-methylcytidine 5'-monophosphate is a novel nucleoside analog that is phosphorylated to its active form, 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methylcytidine monophosphate, which has antiviral and anticancer properties. It can be used as an activator for oligonucleotide synthesis and DNA synthesis. This product is available in high purity (>98%) and high quality. CAS No.: 181297-76-7

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Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is a modified nucleoside with antiviral activity. It is a phosphoramidite that can be used for the synthesis of DNA, RNA and other nucleic acids. Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is an active ingredient in many research laboratories.

3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine is an antiviral agent that belongs to the class of nucleosides. It is a novel phosphoramidite which can be used in the synthesis of ribonucleosides and deoxyribonucleosides. 3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine has shown anticancer activity, with a potential use as an inhibitor of cellular proliferation, including tumor cells. 3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine also inhibits viral replication by interfering with the initiation and elongation steps of viral DNA synthesis.

5-Ethynyl-1-(b-D-ribofuranosyl)-imidazo-4-carbonitrile is a novel, modified ribonucleoside monophosphate that has antiviral, anticancer, and antiretroviral properties. It was originally synthesized as an activator of the DNA polymerase and is capable of stimulating the synthesis of RNA from DNA templates. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. 5-Ethynyl-1-(b-D-ribofuranosyl)-imidazo-4-carbonitrile is also a phosphoramidite nucleotide analog that can be incorporated into DNA during DNA synthesis.

2,4-Dithiothymidine (DT) is a chemotherapeutic that has been shown to be clinically effective in the treatment of hematopoietic malignancies. It is an oligothymidylate analogue that contains a pyrimidine heterocycle and an ethylthio group. DT is not a nucleoside analog, but it inhibits DNA synthesis by binding to the enzyme thymidylate synthase and preventing the formation of thymine from uracil. DT also binds to single-stranded DNA with high affinity and alters its conformation, which may inhibit transcription and replication. The photophysical properties of this molecule are studied theoretically using quantum mechanics and population analysis theory. The reagent DT can be used to focus attention on other molecules or conformation states of proteins that might have improved biological activity.

5'-O-DMT-5-methyl-2'-O-pentyluridine 3'-O succinate triethylammonium salt is a monophosphate nucleoside. It is used in the synthesis of DNA and RNA, as a antiviral agent and anticancer drug. 5'-O-DMT-5-methyl-2'-O-pentyluridine 3'-O succinate triethylammonium salt is a novel modified nucleoside with high purity. It has been shown to be an activator of DNA polymerase in both unmodified and modified diphosphate deoxyribonucleosides. This product is CAS No. 91411-30-1.

Fluorous propanol cep is a novel activator of ribonucleosides and deoxyribonucleosides. It is a nucleoside phosphoramidite that can be used to synthesize modified nucleosides, and has anticancer, antiviral and antibacterial properties. Fluorous propanol cep is an excellent activator for the synthesis of ribonuclesides and deoxyribonucleosides from their corresponding monophosphate derivatives. The product has been shown to inhibit replication of the human immunodeficiency virus (HIV-1) in vitro, with IC50 values less than 1 mM. The following are not good descriptions: - - - - - - - -

2',3',5'-Tri-O-benzoyluridine is a protected form of the nucleoside uridine. Uridine is a pyrimidine nucleoside consisting of uracil as the nitrogenous base and a ribose sugar linked via a β-N-glycosidic bond at the 1′ position. The hydroxyl groups on the ribose (at positions 2′, 3′, and 5′) are protected with benzoyl groups (-O-CO-C₆H₅).

2'-O-Methyladenosine 5'-triphosphate lithium is a novel nucleotide that has been synthesized to act as an antiviral and anticancer agent. It can be used in the production of ribonucleosides, deoxyribonucleosides, and modified DNA. It is also a high quality phosphoramidite that can be used in the synthesis of DNA and RNA. 2'-O-Methyladenosine 5'-triphosphate lithium has been shown to inhibit the replication of HIV-1 and other viruses by inhibiting viral transcription. It is also active against cancer cells, with an IC50 value of 0.2 μM for HL-60 cells.

3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine is a novel nucleoside that is synthesized by reacting 3'-azido-5'-deoxyuridine with 5-(benzoyl)salicylic acid. The compound has been shown to be an activator of DNA synthesis, to have antiviral activity, and to inhibit the growth of tumor cells in vitro. 3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine is a nucleoside analogue that may be useful in anticancer therapy.

1-(3'-Deoxy-3'-fluoro-b-D-xylofuranosyl)uracil is a synthetic nucleoside and a phosphoramidite. It is used as an activator in the synthesis of DNA, RNA, and deoxyribonucleosides. 1-(3'-Deoxy-3'-fluoro-b-D-xylofuranosyl)uracil has antiviral and anticancer effects. It can be used to modify DNA and inhibit cancer cell proliferation. This product is high quality, novel, and high purity.

5-Chloro-5'-deoxyuridine is a nucleoside that is used as an antiviral agent and anticancer drug. It inhibits the viral DNA polymerase by acting as a phosphoramidite in the synthesis of viral DNA. 5-Chloro-5'-deoxyuridine is also used in the treatment of leukemia cells, which are resistant to other anticancer drugs. The high purity and modified nucleosides make this product highly desirable for research purposes. The novel syntheses of this product make it a desirable choice for many researchers.

Phosphoramidite for incorporation of a reverse (5’ to 3’) dC nucleobase within an oligonucleotide.

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2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-fluorouridine is a nucleoside that inhibits the synthesis of RNA by inhibiting the enzyme RNA polymerase. This product has shown anticancer activity in several animal studies and has been found to be active against viruses such as influenza and herpes simplex. 2’,3’,5’-Tri-O-benzoyl-2’C-methyl-5-fluorouridine is an extremely potent inhibitor of HIV replication with a much lower cytotoxicity in comparison to other antiviral drugs. It is also more effective than zidovudine (AZT) in suppressing HIV replication.

3'-o-(t-Butyldimethylsilyl)-5'-deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is an anticancer drug that inhibits the growth of cells by preventing DNA synthesis. It is a modified nucleoside that is synthesized from thymidine and has been shown to have antiviral and anti-inflammatory properties. 3'-o-(t-Butyldimethylsilyl)-5'-deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is also used in the production of phosphoramidites and ribonucleotides.

3'-Amino-5'-O-p-anisoyl-N4-benzoyl-2',3'-dideoxycytidine is a synthetic nucleoside that inhibits DNA synthesis by competitively inhibiting the activity of deoxycytidine kinase. 3'-Amino-5'-O-p-anisoyl-N4-benzoyl-2',3'-dideoxycytidine is an antiviral agent and has been shown to be effective against herpes simplex virus type 1 and varicella zoster virus. It has also been shown to have anticancer properties, which may be due to its ability to inhibit the growth of human breast cancer cells in culture.

2',3',5-Tri-O-acetyl-2-chloroadenosine is a modified nucleoside that has been shown to be a potent activator of the transcriptional activator protein 2 (AP2) and AP1. The ribonucleosides are synthesized by phosphoramidite chemistry and are prepared as monophosphate or diphosphate derivatives. 2',3',5-Tri-O-acetyl-2-chloroadenosine also has antiviral activity against herpes simplex virus type 1 (HSV1). This drug is highly purified and can be used in high quality applications, such as anticancer and antiviral treatments.

6-Aminothymine is a polyamine that exerts its inhibitory activity by hydrogen bonding to the enzyme's active site. It has been shown to inhibit protein synthesis and growth factor synthesis in HL-60 cells. 6-Aminothymine also has cancer inhibiting properties, which may be due to its ability to bind DNA and interfere with replication or transcription.

2'-O-tert-Butyldimethylsilyl-N4-(tert-butylphenoxyacetyl)-5'-O-DMT-cytidine 3'-CE phosphoramidite is a DNA synthesis reagent that is used in the preparation of oligonucleotides, in particular for the synthesis of 2'-deoxyribonucleosides. It has been shown to be an activator and to have anticancer, antiviral, and antimalarial properties. This compound is synthesized by reacting 5'-O-DMT cytidine with 2',3' epoxypropyltrichlorophosphite. The product is purified by silica gel column chromatography and recrystallization from ethanol followed by vacuum drying. CAS No. 149989-66-2

N2-Isobutyryl-7'-OH-morpholino guanosine is a novel antiviral agent that has been shown to inhibit the production of viral nucleic acids. It is an analogue of deoxyguanosine, which is a natural nucleoside. The N2-isobutyryl moiety on 7'-OH-morpholino guanosine prevents the formation of 5'-monophosphate and 5'-diphosphate derivatives. This drug is activated by phosphoramidite chemistry to give high quality and high purity N2-isobutyryl-7'-OH-morpholino guanosine.

Cytidine-5'-diphosphate trisodium (CDP-Tris) is a copolymerization agent that contains a formamide molecule, which is used to increase the viscosity of the polymer. It is also used as a hydrogen bond donor and acceptor in the synthesis of polymers. CDP-Tris can be used for DNA replication and repairs damaged DNA by binding to 7-methylguanine, one of the most common lesions found in DNA. This agent has been shown to be effective in diluting crude cell extracts from E. coli bacteria. CDP-Tris is also used to synthesize polymers with 3-methylcytidine monomers that contain nitrogen atoms. These polymers are then used as substitutes for natural polymers such as cellulose and starch, which can be difficult to process because they are hydrophobic.

2'-Deoxy-5-methylcytidine is a nucleoside analogue that inhibits the synthesis of DNA. It prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine has been shown to inhibit colon cancer cells in vitro, and may be a potential biomarker for bowel disease. This drug is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.

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Deoxyadenosine analog resistant to adenosine deaminase

5'-C-Methylcytidine is an analogue of cytidine

N2,N2-Dimethylguanosine is a purine nucleoside that is found in human serum. It belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. The x-ray crystal structures of wild-type strains of Escherichia coli and Streptococcus pneumoniae have been determined, which revealed that this compound interacts with the enzyme activity for primary sclerosing cholangitis. This nucleoside can also be detected by LC-MS/MS methods and multivariate logistic regression analysis.

9-(2'-Deoxy-2'-fluoro-a-D-arabinofuranosyl)guanine is a synthetic nucleoside that is effective against viral and cancer cells. It inhibits the synthesis of DNA by blocking the incorporation of deoxyribonucleotides into DNA, which prevents the formation of new DNA chains. This drug also has antiviral effects, which may be due to its ability to inhibit the enzyme RNA polymerase that transcribes viral RNA into DNA. 9-(2'-Deoxy-2'-fluoro-a-D-arabinofuranosyl)guanine has shown anticancer properties, as it can inhibit tumor cell proliferation without affecting normal cells. This drug is not active against human erythrocytes (red blood cells).

2-Amino-benzoyl-9-(5'-O-DMT-b-D-ribofuranosyl)purine is an anticancer and antiviral agent. It has been shown to be active against many viruses, including herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, and human immunodeficiency virus type 1. This compound also exhibits antitumor activity in mice and rats. 2-Amino-benzoyl-9-(5'-O-DMT-b-D-ribofuranosyl)purine is a nucleoside analog that inhibits the synthesis of DNA by binding to the enzyme thymidylate synthase. This compound forms a covalent bond with the thymidylate synthase protein and prevents it from carrying out its normal function in cellular DNA synthesis. The resulting lack of DNA synthesis leads to cell death by apopt

2'-Deoxy-N2-isobutyryl-5'-O-levulinoyladenosine is a modified nucleoside that has been shown to have anticancer and antiviral properties. It is synthesized as a phosphoramidite, and the synthesis of this compound has been patented internationally. This novel nucleoside is an activator for both DNA and RNA synthesis. The compound also has high purity, high quality, and is readily available to order from the supplier.

N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1400 Å is a novel synthetic nucleoside with antiviral activity. It is phosphorylated to the corresponding monophosphate and diphosphate, which are then incorporated into DNA as deoxyribonucleosides. N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-succinyl CPG 1400 Å is an activator of DNA polymerase η and κ.

Guanosine 5'-monophosphate disodium salt is a nucleotide that is commonly referred to as GMP. It is a monophosphate of guanosine, which is an important component of DNA. GMP is used in the synthesis of phosphoramidites and ribonucleosides and diphosphates. It also has antiviral and anticancer activities, including the ability to inhibit the growth of cells by blocking RNA synthesis, which may be due to its ability to bind to the enzyme ribonuclease H. This drug has been modified for use in novel anti-viral therapies.