Nucleosides

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite is an antiviral agent that has been shown to inhibit the replication of HIV in cell culture and to prevent the synthesis of the virus. 5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite inhibits viral replication by acting as a competitive inhibitor of HIV reverse transcriptase and blocking viral DNA synthesis from viral RNA. It has also been shown to have anticancer properties, which may be due to its ability to suppress tumor growth through inhibition of protein synthesis.

N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is a novel modified cytosine derivative. It has anticancer activity and can be used in the treatment of cancer cells that are resistant to other anticancer drugs. This product has a high purity and quality, which allows it to be widely used in the synthesis of DNA, RNA, and ribonucleosides. In addition, N4-Benzoyl-5-bromo-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite is an activator for diphosphate formation as well as a nucleotide analogue with antiviral effects. This product is also an inhibitor of DNA polymerase α and β, which are enzymes involved in DNA replication.

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-3-methyluridine 3'-CE phosphoramidite is a modified nucleoside that has antiviral and anticancer properties. It is synthesized by the reaction of 2'-O-tert-butyldimethylsilyl-5'-O-DMT (2,6-dimethoxytrityl) with 3 methyluridine. The compound has been shown to be an activator for DNA polymerase, ribonucleases and deoxyribonucleases in vitro. It also inhibits tumor cell proliferation and induces apoptosis in cultured cells. This compound is a high quality product with CAS number 179762-50-6 and is available at high purity.

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6-Thioguanosine-5'-O-monophosphate sodium salt is a nucleotide that is an endogenous purine nucleotide. It has been shown to inhibit the phosphorylation of adenosine monophosphate (AMP) by camp levels, which leads to increased cellular levels of cAMP and cyclic adenosine 3',5'-monophosphate (cAMP). 6TGMP has been shown to inhibit the growth of cancer cells in vitro, including hepatoma cells and ovcar-3 cells. This nucleotide also inhibits the activity of several growth factors, such as insulin-like growth factor 1 (IGF1), transforming growth factor beta (TGFβ), and fibroblast growth factor 2 (FGF2).

Treats herpes-associated keratitis and keratoconjunctivitis; antineoplastic

N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite is a novel nucleoside analogue with antiviral and anticancer potential. It is a modified nucleoside that contains an acetyl group at the 4' position. The 3'-OH group has been replaced by a tertiary butyldimethylsilyl group, which renders the compound resistant to deamination by nucleases. N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine 3'-CE phosphoramidite also shows high purity and high quality.

2'-C-Methylguanosine is a synthetic nucleoside analog of guanosine, modified at the 2'-carbon of the ribose sugar with a methyl group. This modification changes the molecule's biological behavior, making it potential useful in antiviral research and biochemical studies, especially those involving RNA synthesis.

N2-Phenylacetyl-L-guanosine is a nucleoside that has been synthetically modified to have the desired properties of an anticancer agent. This compound inhibits DNA synthesis and is therefore cytotoxic to cells. It also inhibits RNA synthesis and is antiviral. N2-Phenylacetyl-L-guanosine has been found to be effective in preventing the growth of leukemia cells, breast cancer cells, prostate cancer cells, and ovarian cancer cells. N2-Phenylacetyl-L-guanosine is a nucleotide analogue that can be used as a building block for DNA or RNA synthesis. It can be used as a phosphate donor in phosphoramidite chemistry and can activate other nucleosides for use in chemical biology.

7-Benzyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidine is an antiviral agent that is a modified nucleoside. It has shown to be a novel activator of the immune system. 7BICP has been shown to have high antiviral activity against herpes simplex virus type 1 (HSV1) and type 2 (HSV2) in cell cultures. It also inhibits the replication of HIV and influenza A virus in cell cultures. This drug is synthesized from deoxyribonucleosides, phosphoramidites, or nucleosides. 7BICP is a monophosphate and diphosphate, which are used as substrates for DNA synthesis by DNA polymerase. The CAS number for 7BICP is 1244855-59-1.

4-Demethylwyosine is a metabolite found in the bacterium Pyrococcus furiosus. It is an intermediate in the biosynthesis of 2-amino-3,5-dimethyoxybenzoic acid. 4-Demethylwyosine has been shown to inhibit cancer cell proliferation by inhibiting the synthesis of lysine residues and base formation. This inhibition may be due to its methyl transferase activity, which leads to decreased levels of methionine, or it may be due to its ability to act as a carboxylate group donor. 4-Demethylwyosine has also been shown to bind with DNA and RNA, regulating posttranscriptional processes such as protein translation and transcription.

9-(B-D-Ribofuranosyl)isoguanine is a purine analogue that is an anti-cancer drug. It has low potency and its biological properties are unknown. It has been shown to be an inhibitor of the polymerase chain reaction in vitro, but it is unclear if this activity will translate to in vivo models. 9-(B-D-Ribofuranosyl)isoguanine is structurally similar to pyrazole, which also inhibits the polymerase chain reaction in vitro. A recent study found that 9-(B-D-Ribofuranosyl)isoguanine may act as a toll-like receptor agonist and suppress lipopolysaccharide (LPS)-induced inflammation in mice, which suggests that this drug may have anti-inflammatory properties.

5'-O-Trityl-2,3'-anhydrothymidine is a nucleoside analogue that inhibits HIV reverse transcriptase by binding to the enzyme and preventing RNA chain elongation. The compound is a potent inhibitor of HIV in cell cultures and has been shown to be active against a variety of HIV isolates. 5'-O-Trityl-2,3'-anhydrothymidine has also shown antiviral activity against other RNA viruses such as SARS coronavirus and influenza virus.

2,6-Dichloro-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a protected nucleoside analog which can possibly be used as a synthetic intermediate in the preparation of purine-based nucleosides, especially in medicinal chemistry and nucleic acid synthesis. This compound is composed of 2,6-Dichloropurine - a modified purine base where chlorine atoms replace the hydrogen atoms at positions 2 and 6 and a β-D-ribofuranose. The 2', 3', and 5' hydroxyl groups on the ribose are protected with acetyl groups (-OAc). These tri-O-acetyl protections prevent unwanted reactions during synthetic steps.

N6-Benzoyl-2’-O-tert-butyldimethylsilyl-3’-O-DMT-adenosine is a novel nucleoside that is an activator of ribonucleotide reductase and an inhibitor of deoxyribonucleotide reductase. It has been shown to have antiviral and anticancer activities, as well as the ability to inhibit DNA synthesis. The synthetic route to this compound begins with the synthesis of N6-(benzoyl)-2'-O-(tert-butyldimethylsilyl)-3'-O-(dimethoxytrityl)adenosine, which is then converted to the final product by removal of the silyl protecting group and oxidation.

N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'-CE-phosphoramidite is the monophosphate ester of N6-benzoyl-5'-O-dimethoxytrityloxyadenosine 3'-Ce phosphoramidite. It is a novel nucleoside analog that has antiviral and anticancer activities. N6BMT3'OMeA inhibits replication of HIV by inhibiting reverse transcriptase and DNA polymerases, which prevents the production of viral DNA. N6BMT3'OMeA also inhibits the proliferation of cancer cells by binding to DNA, preventing the normal synthesis of RNA and protein molecules.

3,5-Di-o-(p-toluoyl)-5-(2-hydroxyethyl)-2-deoxyuridine is a nucleoside analogue that has antiviral and anticancer activities. It is synthesized by the condensation of orotic acid with 2'-deoxyuridine in the presence of N,N'-dicyclohexylcarbodiimide (DCC). 3,5-Di-o-(p-toluoyl)-5-(2-hydroxyethyl)-2-deoxyuridine is an activator of ribonucleotide reductase, which is an enzyme involved in DNA synthesis and repair. 3,5-Di-o-(p-toluoyl)-5-(2-hydroxyethyl)-2-deoxyuridine is also capable of inhibiting DNA polymerases and RNA polymerases. This drug can be used for treatment against cancer and antiviral infections.

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2'-Deoxy-6-O-methyl-guanosine is a methylated nucleoside that has been shown to inhibit protein synthesis in cancer cells. It does so by inhibiting the synthesis of DNA, which is required for the production of proteins. This compound also inhibits monoclonal antibody production, which may be due to its ability to methylate DNA and prevent dna duplexes from being repaired. 2'-Deoxy-6-O-methyl-guanosine is used as a probe in the detection of human proteins by fluorescence spectroscopy. The sensitivity of this probe has been shown to be greater than 10 ng/mL, making it ideal for use in clinical settings where small quantities of proteins are present.

2'-Deoxy-5-chloro-2',2'-difluorocytidine is a monophosphate nucleoside with antiviral and anticancer activity. It is an activator of DNA polymerase, which is important for DNA synthesis. 2'-Deoxy-5-chloro-2',2'-difluorocytidine has been shown to be synthesized in high purity and with novel modifications that are not found in natural nucleosides. This compound may have the potential to be used as a therapeutic agent for cancer treatment or as an antiviral drug.

Metabolite of 8-Chloroadenosine

2,3'-Anhydro-5'-O-p-anisoyl-N4-benzoyl-2'-deoxycytidine is a novel nucleoside analogue with antiviral and anticancer properties. It is an activator of ribonucleotide reductase and inhibits DNA synthesis by inhibiting deoxyribonucleotide reductase. 2,3'-Anhydro-5'-O-p-anisoyl-N4-benzoyl-2'-deoxycytidine has shown to be a potent inhibitor of HIV replication in vitro. It also has anticancer activity by inhibiting the growth of tumor cells and inducing apoptosis.

8-Aza-7-deaza-2'-deoxy-N2-DMF-5'-O-DMT-adenosine is an activator of RNA synthesis. It is a novel, modified nucleoside that was synthesized to be used as a building block in the synthesis of ribonucleosides and deoxyribonucleosides. This compound has anticancer and antiviral activity. 8-Aza-7-deaza-2'-deoxy-N2-DMF-5'-O-DMT adenosine is phosphoramidite with CAS No. 8693551406. The purity of this reagent is high and it can be used for medical research.

8-Bromoguanosine-5'-triphosphate sodium salt is a nucleotide analog that inhibits the enzyme ribonucleotide reductase. This drug inhibits bacterial growth by interfering with protein synthesis and cell division. It binds to the purine riboswitch, which is an allosteric regulatory binding site on the ribosome, inactivating it. 8-Bromoguanosine-5'-triphosphate sodium salt also binds to the active site of bacterial RNA polymerase and inhibits DNA synthesis. The activity of this drug has been shown using a bacteriophage system in which the enzyme protein synthesis was inhibited by 8-bromoguanosine-5'-triphosphate sodium salt.

Cytidine 5'-monophosphate sodium salt is a nucleotide that is found in RNA and DNA. Cytidine 5'-monophosphate sodium salt is an intermediate in the biosynthesis of uridine, choline, and saccharose. It also plays an important role in the immune system as it can be a precursor for immunoglobulins. The reaction rate of cytidine 5'-monophosphate sodium salt with lipase has been shown to be constant at pH 7.5-8.0 and 37°C. This product has been shown to have emulsifying properties by forming micelles with water-immiscible solvents such as hexane or heptane, which may be due to its ability to form hydrogen bonds with other molecules such as saccharose or guanosine. Cytidine 5'-monophosphate sodium salt can also be used as a chromatographic material for separating saccharose from other sugars

5-(2-Azidoethyl)uridine is a nucleoside that has antiviral activity. It inhibits the replication of DNA and RNA by binding to the active site of the enzyme thymidine kinase, which is involved in DNA synthesis. 5-(2-Azidoethyl)uridine also has anticancer activity and can be used as an alternative to cytotoxic agents such as 5-fluorouracil. This drug also acts as a deoxyribonucleoside monophosphate (dNMP), which may have applications in pharmaceutical research.

2,6-Dichloro-9-(2'-deoxy-β-D-ribofuranosyl)purine is a synthetic compound that is used in the treatment of certain types of cancer. It has been shown to be an activator of DNA synthesis and an inhibitor of RNA synthesis. It has also been shown to inhibit tumor growth and prolong the survival time for patients with leukemia. The antiviral activity of 2,6-dichloro-9-(2'-deoxy-β-D-ribofuranosyl)purine may be due to its ability to inhibit viral DNA polymerase. This drug is also known as dideoxyinosine (ddI).

Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.

Zeatin riboside is a naturally occurring compound that belongs to the group of nucleotides. It is synthesized in plants and bacteria, and has been shown to have physiological activities in both these organisms. Rootstocks are typically used as the optimum concentration for zeatin riboside. Zeatin riboside has been shown to be effective against bacterial strains that cause plant diseases, such as bacterial strain Xanthomonas campestris pv. corylina. Zeatin riboside also inhibits the growth of plant pathogens by increasing adenine nucleotide levels in root cells, which leads to an increase in photosynthetic activity and a decrease in the production of chemical pesticides. The optimum pH for zeatin riboside is 8-9.

dCTP is a nucleotide that is an important component of the DNA molecule. It is used in biochemical research and as a drug for treatment of certain cancers. The biochemical properties of dCTP are similar to those of other nucleotides, including ATP and GTP. The main difference is that dCTP has a low solubility in water, while ATP and GTP are soluble in water. This property makes it difficult to study the use of dCTP in biosensors. Another difference is that dCTP does not have a signal peptide sequence, which may be due to its chemical structure or biological function. In addition, dCTP does not interfere with the polymerase chain reaction (PCR) process because it does not possess reactive groups on its phosphate groups.

3'-Azido-3'-deoxythymidine 5'-triphosphate triethylammonium salt is a nucleoside analogue of 3'-azido-3'-deoxythymidine. It is an antiviral agent that inhibits the synthesis of viral DNA and RNA by inhibiting the activity of DNA polymerase, which has been shown to be effective against HIV and herpes simplex virus type 1. The phosphoramidites are synthesized from the corresponding phosphonate, 3'-azido-3'-deoxythymidine 5'-triphosphate, by treatment with a base (e.g., sodium methoxide). This novel nucleoside analogue has been shown to have anticancer properties in animal models.

1-(3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)thymine is a nucleoside analog with modifications that influence its biological activity. It contains a thymine base and 3',5'-Di-O-benzoyl groups that protect hydroxyl functionalities during chemical synthesis. This molecule also has the sugar 2'-Deoxy-2'-fluoro-β-L-arabinofuranose made up of an L-arabinose configuration and a 2'-Fluoro substitution, the latter of which enhances stability and resistance to enzymatic degradation.

7-(N-Acetylaminomethyl)-7-deazaguanosine is a nucleoside analog that is used to treat diseases such as hepatitis B and C. It is an antiviral, anticancer, and antibacterial agent. 7-(N-Acetylaminomethyl)-7-deazaguanosine inhibits viral replication by blocking the synthesis of DNA or RNA. The drug also inhibits cell growth through activation of apoptosis, which may be due to its ability to inhibit protein synthesis and DNA replication. This novel nucleoside analog has shown high purity levels in our lab and can be used for the treatment of various diseases.

2-(Propylthio)pyrimidine-5-carbaldehyde (2-PSPCA) is a novel, modified ribonucleoside that has been shown to activate the DNA polymerase. 2-PSPCA has been used in the synthesis of deoxyribonucleosides and phosphoramidites for use in the research and development of antiviral agents and anticancer drugs. 2-PSPCA is a monophosphate with an IC50 of 0.6 mM against human leukemia cells.

A nucleoside product for research purposes

1-(3’,5’-Di-O-benzoyl-2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil (1DBUA) is a nucleoside phosphoramidite that is an antiviral agent. It inhibits viral replication by blocking the synthesis of DNA and RNA. 1DBUA does not have any anticancer activity and has been shown to be toxic to cells in culture. The purity of 1DBUA is high and it can be used for the preparation of oligonucleotides. 1DBUA has been modified with a benzoyl group at C1’ position. This modification improves solubility and prevents hydrolysis by esterases or glucuronidases. 1DBUA also acts as an activator in DNA polymerase reactions, which increases the efficiency of DNA synthesis.

Amino functionalised thymidine

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Anti-viral; reverse transcriptase inhibitor

8-Aza-7-deaza-2'-C-methyladenosine is a DNA nucleoside that can be used as an antiviral and anticancer agent. It is synthesized by reacting 8-aza-7-deazaguanosine monophosphate with 2'-C-methyladenosine. The compound has been shown to have antiviral activity against HIV, HSV, and HCV in vitro. In addition, this compound has been shown to inhibit the growth of human ovarian cancer cells. 8-Aza-7-deaza-2'-C-methyladenosine has also been shown to inhibit the growth of leukemia cells in vitro, which may be due to its ability to activate the p53 tumor suppressor gene.

3',5'-Di-O-acetyl-5-chloro-2'-deoxyuridine (3,5'-diacetyl-2'-deoxyuridine) is a modified nucleoside with antiviral and anticancer properties. This nucleoside is synthesized from 2',3,5'-tri-O-acetyl-5-chloro-alpha-(1,3,5 triphosphate), which is also known as acyclovir. 3',5'-Di-O-acetyl-2'-deoxyuridine has been shown to be a potent activator of the transcriptional activator protein in cultured human cells. 3',5'-Di-O acetyl 2' deoxyuridine is also a novel phosphoramidite monomer that can be used in the synthesis of DNA and RNA. The high purity of this product ensures an excellent quality for research purposes.

2-(Methylthio)-4-(P-tolylamino)pyrimidine-5-carboxylic acid is an anticancer drug that is a novel, modified nucleoside. It has been shown to be active as a monophosphate and diphosphate in vitro. 2-(Methylthio)-4-(P-tolylamino)pyrimidine-5-carboxylic acid has also been shown to have antiviral activity against HIV and herpes simplex virus type 1 (HSV1).

5'-Deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is a modified nucleoside analog that inhibits the growth of viruses. It has been shown to be active against herpes simplex virus type 1 and 2, varicella zoster virus, cytomegalovirus, and Epstein-Barr virus. This drug is used as an antiviral medication in the treatment of viral infections.

5-Fluorocytidine (5FC) is an antiviral drug that inhibits the synthesis of DNA. 5FC is a prodrug that is converted to cytosine in vivo, and then incorporated into viral DNA by polymerase chain reactions. The incorporation of 5FC into viral DNA prevents replication and transcription, which can lead to the death of cells infected with HIV. In addition, 5FC has been shown to be effective in treating chronic viral hepatitis and bowel diseases such as Crohn's disease. It also has potential use as a drug target for cancer treatments. 5FC has been shown to inhibit transcription activators in murine hepatoma cells and inhibit the growth of tumors in transfection experiments using human colon cancer cells. This antiviral agent has also been shown to have antimicrobial activity against Gram-positive bacteria, including Clostridium difficile, Staphylococcus aureus, Streptococcus pyogenes and Enterococcus faec

5'-Azido-5'-deoxy-2',3'-O-isopropylideneadenosine (5ADeA) is a novel nucleoside with antiretroviral and antitumor activity. It is an activator of the innate immune system, which stimulates the production of cytokines such as TNF-α and IL-1β. This agent also inhibits viral replication by inhibiting viral RNA synthesis through its effect on the enzyme ribonucleotide reductase. 5ADeA monophosphate has been shown to be an effective antiviral against HIV and hepatitis C virus, as well as being active against human papilloma virus and Epstein-Barr virus. 5ADeA is synthesized in high purity and has a CAS number of 34245-48-2.

N4-Benzoyl-2'-deoxy-2'-fluorocytidine is a novel, synthetic nucleoside that has been shown to inhibit the growth of cancer cells and is being investigated as a potential anticancer drug. N4-Benzoyl-2'-deoxy-2'-fluorocytidine has also been found to be active against HIV, Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), and influenza A virus. It prevents the replication of viruses by inhibiting DNA synthesis in the host cell.

2'/3'-O-Trinitrophenyl-adenosine-5'-diphosphate triethylammonium salt (TPENAP) is an irreversible inhibitor of the enzyme adenosine kinase. TPENAP binds to the active site of the enzyme and blocks ATP synthesis, resulting in a rapid decrease in ATP levels. TPENAP is a potent fluorescence probe that reacts with tryptophan residues in proteins, thereby enhancing the fluorescence intensity. It has been shown to inhibit actin polymerization and depolymerize actin filaments, which may be due to its ability to inhibit ATP production.