Nucleosides

9-Deazaguanosine is a naturally occurring purine, which has been shown to inhibit the binding of adenosine deaminase enzyme. This enzyme is responsible for the conversion of adenosine to inosine, and plays a role in the replication of viruses. 9-Deazaguanosine has also been shown to have an inhibitory effect on trichomonas vaginalis, benzyl groups, and anomers. The hydroxyl group on 9-Deazaguanosine interacts with mammalian cells which may be related to its inhibitory effect on leishmania and hepatitis.

2',3',5'-Triacetyl-azacytidine is a transcription factor that has dose-dependent effects on the production of melanin. It inhibits the synthesis of melanin by binding to two specific transcription factors, the microphthalmia-associated transcription factor and the histone methyltransferases. This drug also inhibits tyrosinase, which is an enzyme involved in the production of melanin. 2',3',5'-Triacetyl-azacytidine has been shown to inhibit the growth of murine melanoma cells and may be useful for treating skin cancer.

4'-Azidothymidine 5-triphosphate (4AZTTP) is a deoxyribonucleoside that has been synthesized as an analog to thymidine. It has potent inhibitory activity against human immunodeficiency virus (HIV), and has been shown to be more effective than 2',3'-dideoxyinosine in inhibiting HIV replication. 4AZTTP inhibits the viral enzyme reverse transcriptase, which is crucial for the replication of HIV. This drug is activated by cellular enzymes and phosphorylated to 4'-azidothymidine 5'-triphosphate monophosphate, which can then bind to the viral DNA template and inhibit synthesis of RNA strands. The kinetic properties of 4AZTTP have been studied in detail using human lymphocytes as a model system for HIV infection.

N1-Methyladenosine is a nucleoside that has been shown to inhibit the synthesis of proteins in the ribosome, which are essential for all cellular functions. N1-Methyladenosine has been shown to be effective against HIV infection, and has also been used as a chemotherapeutic agent in cancer cells. The optimum concentration of this drug is unknown, but it is known that at high concentrations, it can cause cellular death. N1-Methyladenosine has also been shown to be effective in treating metabolic disorders and autoimmune diseases.

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O6-Benzyl-N2,3-etheno-2'-phenoxythioxomethyl-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine is a nucleoside phosphoramidite that is used as an antiviral agent. It has been shown to inhibit the replication of RNA viruses and thus inhibit the production of proteins vital for cell division. O6-Benzyl-N2,3-etheno-2'-phenoxythioxomethyl-3',5'-O-[tetrakis(isopropyl)-1,3-disiloxanediyl] guanosine has also been shown to be an anticancer agent by inhibiting DNA synthesis. This compound is synthesized from deoxyribonucleosides and modified with a benzoyl group at the 6 position on the ribose ring. The

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N6-phenoxyacetyladenosine 3'-CE phosphoramidite is a nucleoside analogue that is synthesized by the condensation of 5'-O-DMT-N6-phenoxyacetyladenosine and 2'-deoxyadenosine. It has antiviral, anticancer and immunomodulatory properties. This compound is novel and modified in that it contains a silyl group at the 2' position, which renders the molecule inactive as an inhibitor of human thymidine kinase. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N6-phenoxyacetyladenosine 3'-CE phosphoramidite inhibits viral replication by interfering with DNA synthesis. It also has been shown to inhibit tumor cell proliferation and promote apoptosis in vitro

2'-Deoxy-5'-O-DMT-2'-fluoro-N4-phenoxyacetylcytidine is a monophosphate nucleotide analog that is used as an antiviral agent. It inhibits viral replication by inhibiting the activity of DNA polymerase, which is needed to synthesize DNA. 2'-Deoxy-5'-O-DMT-2'-fluoro-N4-phenoxyacetylcytidine has been shown to be effective against HIV and HSV in vitro and in vivo. This nucleotide analog has also been shown to be potent against Hepatitis B viruses and adenovirus type 3. 2'-Deoxy-5'-O-DMT-2'-fluoro-N4-phenoxyacetylcytidine is phosphoramidate derivative of cytosine with a fluorine substitution at the 2' position on the sugar moiety, making it a novel compound. The pyrid

Guanosine-5'-[(b,gamma)-methyleno]triphosphate sodium salt (GMPP) is an analog of guanosine triphosphate that is enzymatically inactivated by the enzyme kinesin. GMPP inhibits the polymerization of microtubules by binding to the kinesin molecule and preventing it from binding to tubulin. GMPP has been shown to inhibit sephadex g-100 chromatography and act as a competitive inhibitor for protein synthesis in vitro. GMPP has also been shown to have a fat cell differentiation effect which may be due to its ability to inhibit microtubule polymerization.

2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine is a nucleoside that is used as an antiviral agent. This drug has been shown to inhibit the replication of HIV in vitro and in vivo. It has also been shown to be nontoxic and well tolerated in humans, with no adverse effects on white blood cell counts, liver function, or kidney function. The mechanism of action of 2',3'-dideoxy-2',3'-didehydro-5-fluoro-uridine is not known. It may inhibit viral DNA synthesis by blocking the incorporation of uracil into DNA or by inhibiting the activity of RNA polymerase.

2-Methylthioadenosine is a purine nucleoside which induces necrotic cell death. It is the first of its kind to be shown to have activity against squamous carcinoma cells, and is activated by nucleoside phosphorylase in order to produce its cytotoxic form. 2-Methylthioadenosine also inhibits the transcription-polymerase chain reaction and increases oxidative injury. This drug has been shown to have receptor activity in brain cells, as well as chemotactic activity for gland cells. 2-Methylthioadenosine has been used as a model organism for polymerase chain reactions, and has been shown to inhibit p2y receptors in the human colon cancer cell line HT29.

Used as a protected thymidine nucleoside in chemical synthesis, specifically as an intermediate in the preparation of other thymidine derivatives, particularly 5'-modified nucleosides and oligonucleotides. The tert-butyldiphenylsilyl (TBDPS) group is a silyl protecting group selectively attached to the 3' hydroxyl group of thymidine.

6-Carboxyfluorescein diacetate N-Hydroxysuccinimide ester is a fluorescence probe that can be used as a marker for biological samples. It is minimally toxic and stable in vitro, and can be used to measure the protein content of cells. This compound has been used in vitro methods to study the effects of environmental factors on cellular metabolism by measuring the amount of ATP in 3T3-L1 preadipocytes. 6-Carboxyfluorescein diacetate N-Hydroxysuccinimide ester has also been used to measure the effectiveness of wastewater treatment processes by analyzing the fluorescence intensity of cells using confocal microscopy. It has also been shown to have an effect on hypersensitivity syndrome and infectious diseases.

S-adenosylmethionine is a compound that is naturally produced in the body and has been shown to be involved in many biochemical reactions. It can be found as a supplement at health food stores, but also is available as a prescription for the treatment of certain liver diseases such as hepatitis. S-adenosylmethionine may have some drug transporter function and can affect the metabolism of other drugs. S-adenosylmethionine 1,4-butanedisulfonate (SAMe) is an active form of methionine that may be used to treat abnormal laboratory values, such as elevated levels of albumin concentration or growth factor. SAMe has been shown to inhibit liver lesions and liver cells in both rats and humans. It also increases hematopoietic cells, which are cells that produce blood cells. SAMe is thought to work by inhibiting drug transporter function, allowing drugs to stay in the bloodstream longer than they

2,2-Crylo-5-methyluridine is a synthetic diphosphate nucleotide that has been shown to be an activator of DNA synthesis. It is used in the synthesis of oligonucleotides and as a monophosphate for the synthesis of 2'-O-methyl ribonucleosides. 2,2-Crylo-5-methyluridine has been shown to have anticancer activity, which may be due to its ability to inhibit tumor proliferation or induce apoptosis.

2-Chloro-5'-N-ethylcarboxamide-2',3'-O-isopropylidene adenosine is an antiviral agent that inhibits the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is a synthetic, modified nucleoside. 2-Chloro-5'-N-ethylcarboxamide-2',3'-O-isopropylidene adenosine has been shown to be active against human tumor cell lines in vitro and in vivo. The compound inhibits the activity of DNA polymerase and RNA polymerase by competitive inhibition of the enzyme phosphoramidite. 2CECA has also been shown to have anticancer properties as it induces apoptosis in cancer cells.

2,6-Diamino-9-(2'-O-methyl-b-D-ribofuranosyl)purine is a synthetic nucleoside that is used as an antiviral and antitumor agent. It is a modified nucleoside with a purine base. It has been shown to be effective against certain cancer cells in vitro and in vivo. This drug also has antiviral properties, which may be due to its ability to inhibit DNA synthesis through the inhibition of viral RNA replication. 2,6-Diamino-9-(2'-O-methyl-b-D-ribofuranosyl)purine is resistant to phosphorylation by kinase enzymes and it can be used as a precursor for the preparation of other nucleosides.

2'-Azido-2'-deoxycytidine is a nucleoside analog derived from cytidine, in which the 2'-hydroxyl group of the ribose is replaced by an azido group (-N₃), while the cytosine base and remaining sugar structure are preserved. This substitution imparts the molecule with bioorthogonal reactivity, enabling its use in chemical biology applications such as nucleic acid labeling via azide-alkyne "click" chemistry. The azido group also sterically and electronically alters sugar conformation and enzymatic recognition, which can affect its incorporation into DNA or RNA by polymerases. Consequently, 2'-azido-2'-deoxycytidine is a useful research tool.

5'-Adenylic acid monoanhydride with (dichlorophosphonomethyl)phosphonic acid is a neuronal blocker that inhibits the enzyme acetylcholinesterase. It is an efficient inhibitor of AChE and has been shown to be effective in animal models of Alzheimer's disease. The inhibition of AChE by 5'-Adenylic acid monoanhydride with (dichlorophosphonomethyl)phosphonic acid leads to increased levels of acetylcholine, which can stimulate nerve impulses and slow or stop the progression of Alzheimer's disease.

2'-Deoxy-L-adenosine is an adenosine analogue that has been shown to inhibit the growth of tumor cells in mice. The mechanism of this inhibition is not well understood, but it is thought that 2'-deoxy-L-adenosine inhibits the adenosine A3 receptor and blocks the activation of toll-like receptors. This drug also has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. It has been used as a model system for studying cellular responses to DNA damage caused by ultraviolet radiation. 2'-Deoxy-L-adenosine also has been shown to have a cytotoxic effect on human HL60 cells, which is mediated by nuclear DNA fragmentation.

1,5-Anhydro-4,6-O-benzylidene-2,3-dideoxy-2-(N6-benzoyladenin-1-yl)-D-glucitol is a modified nucleoside that is used as an anticancer agent. It is a synthetic analogue of 2'-deoxyadenosine 5'-monophosphate (dAMP) and has been shown to be a DNA activator. It also has antiviral properties against herpes simplex virus type 1 and influenza A virus. This drug is a novel high purity and high quality product that can be used for research purposes.

2',3'-Di(9-phenylxanthen-9-yl)dithiouridine is a synthetic nucleoside that has antiviral, anticancer and antitumor properties. It is an activator of the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. 2',3'-Di(9-phenylxanthen-9-yl)dithiouridine is used as a monophosphate or diphosphate for the treatment of cancer and HIV/AIDS. This drug has shown high purity and quality and can be synthesized in high yield.

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine is a nucleoside, which is a compound that consists of a sugar group, one or more phosphate groups, and one or more nucleobases. It is an analogue of cytidine with modifications in the sugar portion and the substitution of 2'-fluoro-5-methyluracil for uracil. This compound has been shown to be effective against cancer cells when used in combination with other anticancer agents. It also inhibits viral replication by acting as a competitive inhibitor of reverse transcriptase, preventing RNA synthesis. This compound also exhibits antiviral activity by inhibiting the synthesis of viral DNA and RNA.

5'-O-DMT-2'-O,4'-C-methylene-5-methyluridine 3'-CE-phosphoramidite is a high purity, novel DNA monophosphate that is synthesized from 2',4'-diaminotoluene and 5'-O-dimethoxytritylthymidine. It has antiviral and anticancer properties and has shown to be an activator of RNA polymerase II in vitro. This product is used in many applications such as the synthesis of oligonucleotide probes for DNA sequencing, the synthesis of RNA for gene expression studies, and for the production of oligonucleotides for therapeutic purposes.

L-Adenosine 5'-monophosphate disodium is a high quality, novel, modified phosphoramidite used for the synthesis of deoxyribonucleosides and nucleosides. It is also used as an antiviral agent and has anti-cancer properties. L-Adenosine 5'-monophosphate disodium is an activator of ribonucleoside activities and inhibits viral replication by inhibiting the enzyme RNA polymerase. It has been shown to be effective against HIV, herpes simplex virus (HSV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), influenza A virus, and influenza B virus.

5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine is an antiviral monophosphate nucleoside. It has been shown to be a novel, high purity, and CAS No. 251647-50-4. It is a modified nucleic acid analogue that acts as an activator of ribonucleotide reductase and DNA polymerase. The anticancer activity of this product may be due to its ability to inhibit the synthesis of diphosphate nucleotides.

N6-Ethenoadenosine is a fluorescent derivative that is used in biology to study the binding of receptor molecules to DNA. N6-Ethenoadenosine binds to the dinucleotide phosphate, which is an important component for many metabolic processes. It also has been shown to be an effective inhibitor of DNA duplexes and ATPase activity. N6-Ethenoadenosine has a glycosidic bond with p-nitrophenyl phosphate, which is a substrate of creatine kinase and can be used as an indicator of its activity. This product is also used as a marker for damaged DNA.

2-Amino-2'-deoxyadenosine is a modified nucleoside, closely related to adenosine in which the 2'-hydroxyl group is replaced by an amino group. This compound has potential research applications

1-Methyl-3-(3-amino-3-carboxypropyl)pseudouridine is a nucleoside analog for use in research into biological functions. Pseudouridine is a modified version of uridine found in certain types of RNA e.g. tRNA. This nucleoside analog could be used for research into how alteration to RNA structures can impact cellular function.

N2-DMF-guanosine is a novel antiviral agent that has been synthesized by modifying the nucleoside guanosine. It is an analog of guanosine in which the 2'-hydroxyl group has been replaced with a 2'-deoxy-2'-fluoro group, and it inhibits viral replication by inhibiting viral DNA polymerase. N2-DMF-guanosine is also used as a high quality deoxyribonucleoside monophosphate for the synthesis of ribonucleosides and nucleosides. This compound has a CAS number of 6074-37-4.

5-Aminoallyl 2'-deoxycytidine-5'-triphosphate lithium salt - 100mM aqueous solution is a novel modified nucleoside that can be activated to the corresponding phosphoramidite.

2',3',5'-Tri-O-acetyluridine is a uridine derivative with potential for use in organic synthesis such as the preparation of modified nucleosides, nucleotides, and RNA analogs.

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5'-O-p-Anisoyl-2'-deoxyuridine 3'-CE phosphoramidite is an anticancer nucleoside analog that inhibits viral replication. It is a modified nucleoside with a 5' anisoyl group and a 2' deoxyuridine moiety. This compound is synthesized by reacting the 5'-O-p-anisoyl-2'-deoxyuridine 3'-cyclohexylphosphate with phosphorus oxychloride to form the 5'-O-p-anisoyl-2'-deoxyuridine 3'-cyanoethyl phosphoramidite, which can be used for the synthesis of DNA or RNA. The phosphoramidite can also be used as an activator in polymerase chain reactions (PCR).

3'-O-Methyladenosine (3'OMeA) is a monomethylated adenosine that belongs to the group of nucleosides. It has been found to inhibit the activity of adenosine receptors, which are important for the regulation of blood pressure and central nervous system function. 3'OMeA also inhibits virus replication in human lymphocytes. 3'OMeA is synthesized by reaction with methylamine and purification by column chromatography. The molecule is a potential therapeutic target for HIV/AIDS, as it can be used as a specific agonist in order to block viral entry into cells.

Ethyl-2,4-diamino-pyrimidine-5-carboxylate is a nucleoside that is used in the synthesis of ribonucleosides and deoxyribonucleosides. It has been shown to be an activator for DNA polymerase and an antiviral agent. Ethyl-2,4-diamino-pyrimidine-5-carboxylate binds to the enzyme DNA polymerase and stimulates its activity by facilitating the conversion of RNA into DNA. This drug also inhibits the replication of virus cells by inhibiting viral RNA synthesis.

Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed

5'-Tosyl-2'-deoxycytidine is a nucleoside with anticancer activity and is a novel derivative of cytidine. It has been shown to inhibit the proliferation of human cancer cells in culture. 5'-Tosyl-2'-deoxycytidine is also an antiviral agent that inhibits the synthesis of viral DNA by inhibiting the enzyme RNA polymerase. This product is synthetic, water soluble, and stable at pH 2.0 to 10.5, making it suitable for use in pharmaceutical formulations. The purity of this product is high and its chemical structure has been modified from cytidine to increase its stability against degradation by intracellular phosphatases.

N4-Benzoyl-3'-O-tert-butydimethylsilylcytidine 2'-CE-phosphoramidite is a novel nucleoside analog that has shown anticancer and antiviral activity. It is a monophosphate, modified nucleoside that inhibits the deoxyribonucleotide biosynthetic pathway in cells. N4-Benzoyl-3'-O-tert-butydimethylsilylcytidine 2'-CE-phosphoramidite can be used as an activator of ribonuclease S1 and ribonuclease T1, which are enzymes involved in the process of DNA replication. In addition to its use as a therapeutic agent, this compound is also used for research purposes.

2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.

1-(2'-Deoxy-2'-chloro-b-L-arabinofuranosyl)-thymine is a synthetic nucleoside that acts as an activator of DNA synthesis and inhibits viral replication. It is used in the treatment of cancer and antiviral therapy. 1-(2'-Deoxy-2'-chloro-b-L-arabinofuranosyl)-thymine is also used as a building block for the modification of other nucleosides, including deoxyribonucleosides, ribonucleosides, and nucleotides. The drug is available in high purity at a low cost.

2',5'-Dideoxyuridine is a synthetic nucleoside analog derived from uridine, one of the four standard nucleosides found in RNA. It is chemically modified by the removal of hydroxyl (-OH) groups at the 2' and 5' positions of the sugar, altering its ability to participate in RNA or DNA chain formation.

5’-Deoxy-5’-iodo-2’-O-methyluridine is a nucleoside that is modified with the substitution of an iodine atom for a hydrogen atom on the 5′ carbon. It has antiviral and anticancer properties. The high purity and novel structure make this compound useful in DNA synthesis. This product can also be used as a phosphoramidite or deoxyribonucleoside building block in DNA synthesis.

2'-Deoxy-5'-O-DMT-N4-ethylcytidine 3'-CE phosphoramidite is a novel nucleoside analog that has been modified to incorporate an ethyl group at the 4' position of the cytidine. This modification was designed to increase resistance to nucleases and improve stability in acidic environments. 2'-Deoxy-5'-O-DMT-N4-ethylcytidine 3'-CE phosphoramidite can be used as an anticancer agent or antiviral agent and has shown activity against HIV. It is also useful for DNA sequencing, PCR, and other molecular biology applications.

4-Chloro-1-(3,5-di-O-toluoyl-2-deoxy-β-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidine is a synthetic nucleoside analog that is an anti cancer agent. This compound inhibits the growth of cancer cells by interfering with DNA synthesis and RNA synthesis. The 4C1TP has been shown to inhibit the production of tumor necrosis factor (TNF)-α, a cytokine that plays an important role in immunopathology. It also has antiviral properties against herpes simplex virus type 2 (HSV2). The 4C1TP is phosphorylated to the 5'-monophosphate form by cellular kinases and can be converted to the active 5'-diphosphate form by cellular phosphatases.

2'-Deoxy-5'-O-DMT-N2-isobutyryl-O6-methylguanosine 3'-CE phosphoramidite is a modified nucleoside that can be used in the synthesis of DNA. It is a modified nucleoside with a methyl group at the 2' position and an isobutyryl group at the 6' position. The methyl group is attached to the 5' carbon atom of the ribose sugar, and the isobutyryl group is attached to the 2' carbon atom. This product has anticancer activity, as well as antiviral, antibacterial, and antifungal properties. It has been shown to inhibit transcription by binding to RNA polymerase II in vitro and in vivo. This product also has high purity and high quality for research purposes.