Beta Blockers

Applications An Epinephrine (E588585) derivative formed in injection solutions and eye drops during sterilization and storage of L-Epinephrine Bitartrate. References De Mol, N.J. et al.: Pharmac. Week., 117, 1 (1982); Liu, C. et al.: Yao. Fen. Zaz., 2, 200 (1982);

Applications Labelled Moxonidine (M745800). Moxonidine is an antihypertensive agent. References Rayment, S. et al.: Brit. J. Pharmacol., 160, 1727 (2010); Taksande, B. et al.: Eur. J. Pharmacol., 637, 89 (2010); Nasr, M. et al.: Vas. Pharmacol., 53, 53 (2010);

Applications 4-Methyl-1-hydrazinophthalazine is used in the synthesis of novel phthalazine derivatives as antihypertensive agents.

Applications A dihydropyridine calcium channel blocker. Enantiomer R of Felodipine. References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981), Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002), O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006),

Applications A labelled metabolite of Pravastatin (P702000), a competitive inhibitor of HMG-CoA reductase. References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000)

Stability Light Sensitive Applications An impurity of Fluvastatin.

Aromatic drugs of amino-alcohols, other than those cont

Sulfonamides, nesoi

Applications Hydroxyacetone is a chemical reagent used in various organic chemical reactions. It is a component of the Mannich reaction, amino acid caalyzes direct asymmetric aldol reactions. In the pharmaceutical setting, this compound is used in the synthesis of imidazoles acting as potent and orally active antihypertensive agents. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sakthivel, K. et al.: J. Am. Chem. Soc., 123, 5260 (2001); Carini, D. et al.: J. Med. CHem., 34, 2525 (1991); List, B. et al.: J. Am. Chem. Soc., 122, 9336 (2000);

Applications Dabigatran Carboxamide Ethyl Ester is an impurity of Dabigatran Etexilate Mesylate (D100150) which is a nonpeptide, direct thrombin inhibitor. References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)

Applications Azimilide Dihydrochloride is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tran, H.T., et al.: Heart. Dis., 1, 114 (1999); Conway, E., et al.: Am. J. Cardiol., 102, 12 (2008); Carlson, M., et al.: Exp. Rev. Cardio. Therap., 3, 387 (2005); Dorian, P., et al.: J. Cardio. Pharm. Therap., 7, 211 (2002);

Applications Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol. References Sterk, D.; et al.: Tetrahedron Lett., 57, 1338 (2016); Olsson, A. G.; et al.: Am. Heart J., 144, 1044 (2002).

Impurity Tranexamic EP Impurity A Applications Tranexamic Acid Dimer (Tranexamic EP Impurity A) is a Tranexamic Acid (T714505) impurity.

Carteolol hydrochloride is a nonselective beta-blocker used to treat hypertension, arrhythmias, angina, and glaucoma.

Applications A metabolite of Cilostazol (C441500), used as internal standard. References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),

Applications Phentolamine Hydrochloride ia an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma. References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949), Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970), Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976)

Levobetaxolol (AL-1577A/Betaxon) is a beta-blocker for ocular hypertension and glaucoma.

(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

Applications The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),

Applications Used as an antihypertensive. Diuretic. References Leary, et al.: Curr. Ther. Res., 15, 571 (1973), Kyncl, J., et al.: Arzneim.-Forsch., 25, 1491 (1975), DiFeo, T.J., et al.: Anal. Profiles Drug Subs. Excip., 23, 229 (1994),

4-(2-Methoxyethyl)phenol is a synthetic compound that is an antihypertensive agent. It is used to reduce high blood pressure, which may be due to its ability to block the action of angiotensin II, a potent vasoconstrictive hormone, by binding with its receptor. 4-(2-Methoxyethyl)phenol has been shown to be more potent than metoprolol succinate and less toxic than hydroxylated compounds such as propranolol in pharmacokinetic studies. In addition, 4-(2-Methoxyethyl)phenol has been found to have a low risk of congestive heart failure. The industrial process for this substance involves the reaction of hydrochloric acid with phenol in the presence of a catalyst such as aluminium chloride or zinc chloride.