Beta Blockers

3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol is a synthetic intermediate. It is metabolized from the drug product 3-[4-(2-Methoxyethyl)phenoxy]propionic acid and may be used as an impurity standard for this compound. This chemical is a high purity, pharmacopoeia grade material that is suitable for use in drug development and pharmaceutical research. 3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol has a natural origin and can be produced synthetically or through biotransformation of other compounds.

Applications α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),

Applications Labelled Reserpine (R144600). An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive. References Muller, J.M., et al.: Experientia, 8, 338 (1952), Schirmer, R.E., et al.: Anal. Profiles Drug Subs., 4, 384 (1975), Diener, R.M., et al.: Toxicol. Pathol., 8, 1 (1980),

Applications Labelled Diogoxin (D446575). Cardiotonic. A representative lot is 95.4% d3, 3.4% d2, 1.2% d1 no dectable d0. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Aronson, J.K., et al.: Clin. Pharmacokinet, 5,137 (1980), Foss, P.R.B., Anal. Profiles Drug Subs., 9, 207 (1980),

Applications Inhibits the enzyme HMG-CoA reductase in vitro. References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),

Applications Coronary vasodilator. Antianginal. References Fujita, et al.: Jpn. J. Pharmacol., 17, 19 (1967), Harpey, C., et al.: Cardiovasc. Drug Rev., 6, 292 (1989),

Applications N6-Isopentenyladenosine has antiproliferative activity on MCF-7 breast cancer cells. References Rajabi, M. et al.; DNA Cell Biol.; 29, 687 (2010)

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),

Impurity Olmesartan Impurity RNH 6363 Applications Olmesartan acid (O550001) derivative. A nonpeptide angiotensin II receptor antagonist. References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),

Stability Light Sensitive Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),

Stability Moisture Sensitive Applications Fenquizone is a thiazide-like diuretic commonly used for antihypertensive therapy. References Costa, F., et al.: J. Clin. Pharmacol., 30, 254 (1990); Maggi, G., et al.: Arzneimittel-Forsch., 35, 994 (1984);

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Applications (S)-(-)-Hydroxy Timolol is a metabolite of the non-selective beta-adrenergic receptor blocker, Timolol (T443710). References Volotinen, M. et al.: Basic Clin. Pharmacol. Toxicol., 106, 302 (2010);

Applications Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. References Demolis, P., et al.: Fundam. Clin. Pharmacol., 8, 80 (1994), Vandenburg, M.J., et al.: Br. J. Clin. Pharmacol., 37, 265 (1994),