Beta Blockers

Labetalol EP Impurity C is a synthetic impurity standard that is used to calibrate HPLC columns and for the quantification of labetalol in drug products. Labetalol EP Impurity C is a metabolite of labetalol and has been shown to have similar pharmacological properties. Labetalol EP Impurity C is synthesized by ester hydrolysis. The purity of this compound exceeds 99%.

Applications Arbutamine is a cardiac stimulant. Arbutamine stimulates adrenergic receptors. References Sinusas, A., et al.: J. Nucl. Med., 35, 664 (1994); Sansoy, V., et al.: Circulation, 92, 994 (1995); Elhendy, A., et al.: Eur. J. Nucl. Med., 23, 1354 (1996);

Applications A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. References Breuer, O., et al.: J. Lipid Res., 36, 2275 (1995), Pikuleva, I., et al.: J. Biol. Chem., 273, 18153 (1998), Chawla, A., et al.: Science, 294, 1866 (2001), Bodin, K., et al.: J. Biol. Chem., 276, 38685 (2001),

Applications Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor. References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)

Applications Atorvastatin (A791750) impurity.

Applications 3’,5’-Dihydrodiol Simvastatin is a metabolite of Simvastatin (S485000). References Vyas, K.P., et al.: Drug Metab. Sispos., 18, 203 (1990); Nakamura, T., et al.: Xenobiotica, 21, 277 (1991); Cheng, H., et al.: Drug Metab. Dispos., 22, 139 (1994);

Applications An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells. References Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);

Applications A dextrorotatory stereoizomer of Quinine. Antiarrhythmic (class IA). Antimalarial. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 483 (1983), Mason, J. W., et al.: Ann. N. Y. Acad. Sci., 432, 162 (1984),

Applications Atorvastatin impurity. Atorvastatin Methyl Ester References Graul, A., et al.: Drugs Future, 22, 956 (1997),

Applications The main metabolite of (R)-Propranolol. References Shwed, J., et al.: Xenobiotica, 22, 973 (1992), Fujita, K., et al.: Biol. Pharm. Bull., 22, 446 (1999), Walle, U., et al.: Drug Metab. Dispos., 30, 564 (2002),

rac-N-Desisopropyl-N-ethyl acebutolol is a synthetic drug product. It is an analytical standard for the impurity, acebutolol, and is metabolized by cytochrome P450 3A4 to form the major metabolite, N-desisopropyl acebutolol. rac-N-Desisopropyl-N-ethyl acebutolol is a research and development product that can be custom synthesized to meet specific needs. It has been shown to have antihypertensive properties in rats and monkeys. This product is not intended for human use.

Applications Azilsartan is an analgesic and antiinflammatory drugs containing angiotensin II antagonists. References Kohara, Y., et al.: J. Med. Chem., 39, 5228 (1996), Plomgaard, P., et al.: Diabetes, 54, 2939 (2005), Fenton, C., et al.: Drugs, 2005, 65, 537,

Applications Lipstatin, a potent inhibitor of the pancreas lipase, is reported to be useful in the treatment and/or prevention of obesity and related diseases. References Derosa, G, et al.: Curr. Therap. Res., 63, 621 (2002), Skinner, D., et al.: J. Bacteriol., 177, 183 (1995),

Applications Propoxyphenyl-thiohydroxyhomosildenafil is an analogue of Hydroxythiohomo Sildenafil (H963150). References Balayssac, S., et. al.: J. Pharmaceut. Biomed., 63, 135 (2012)

Stability Hygroscopic Applications A competitive inhibitor of HMG-CoA reductase. Antilipemic. References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),

Applications Dopamine 3-O-Sulfate, is a metabolite of Dopamine (D533780), that has been shown to have the hypotensive effects in anesthetized rats. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Minami, M., et al.: Biogenic Amines, 11(6), 487 (1995);