Beta Blockers

Applications Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol. References Sterk, D.; et al.: Tetrahedron Lett., 57, 1338 (2016); Olsson, A. G.; et al.: Am. Heart J., 144, 1044 (2002).

Impurity Tranexamic EP Impurity A Applications Tranexamic Acid Dimer (Tranexamic EP Impurity A) is a Tranexamic Acid (T714505) impurity.

Carteolol hydrochloride is a nonselective beta-blocker used to treat hypertension, arrhythmias, angina, and glaucoma.

Applications A metabolite of Cilostazol (C441500), used as internal standard. References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),

Applications Phentolamine Hydrochloride ia an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma. References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949), Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970), Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976)

Levobetaxolol (AL-1577A/Betaxon) is a beta-blocker for ocular hypertension and glaucoma.

(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

Applications The S-(-)-form of Warfarin (W498500). Coumarin anticoagulant. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),