Natural Products and Phytochemicals by Botanical Origin

Applications Paroxetine derivative; piperidine derivative useful as calcium overload blockers for brain cells. References Rice, K.C., et al.: J. Med. Chem., 20, 164 (1977),

Icarisid II is a bioactive natural product, which is a secondary metabolite derived from the flavonoid group found in particular plants. It primarily originates from species in the Epimedium genus, commonly known as "horny goat weed." The mode of action of Icarisid II involves the modulation of various cellular signaling pathways that are critical in cancer pathogenesis, including the inhibition of specific protein kinases and the induction of apoptosis in cancer cells. The primary uses and applications of Icarisid II are in the area of oncological research, where it is being investigated for its antiproliferative and pro-apoptotic effects on cancer cells. Scientists are particularly interested in its potential use as a therapeutic agent in treating various forms of cancer due to its ability to disrupt cell cycle progression and enhance the efficacy of existing chemotherapy agents. Research is ongoing to further elucidate its mechanisms of action and to assess its safety and efficacy in preclinical and clinical settings. The exploration of Icarisid II may lead to novel approaches in developing more effective cancer treatments.

Corycavine is an alkaloid compound, which is derived from certain species of Corydalis plants, particularly from their roots. This naturally occurring substance acts primarily as an alpha-adrenoceptor antagonist, modulating adrenergic signaling pathways. By competitively inhibiting the binding of endogenous catecholamines such as norepinephrine, it influences vascular tone and other physiological processes mediated by alpha-adrenergic receptors. Corycavine is employed in pharmacological research to understand alpha-adrenergic receptor functions and to explore potential therapeutic avenues for conditions like hypertension, where modulation of vascular resistance is crucial. Its role in experimental settings allows scientists to dissect adrenergic mechanisms and develop novel therapeutic strategies. Understanding the pharmacokinetics and specific interactions of Corycavine with cellular targets is vital for elucidating its impact within biological systems, potentially guiding the development of future adrenergic modulators.

Stevia glycoside is a natural sweetener found in the medicinal herb Stevia rebaudiana Bertoni. Stevia glycoside is a low calorie, high-intensity sweetener and is up to three hundred times sweeter than sucrose. Due to the sweet taste of Stevia glycoside, it has a high commercial value throughout the world as sugar substitute in medicine, foods products and beverages. The Stevia plant contains also other steviosides, which include: rebaudioside A, rebaudioside D and dulcoside D, all of which are known as Stevia sweeteners (Mathur, 2017).