Carbohydrates and glycoconjugates

Fully acetylated cellohexoses, part of a polymer homologous series of oligosaccharides isolated from cellulose by acetolysis followed by chromatography.

The core trisaccharide of the ganglioside GD2,protected with a propargyl glycoside group, is the most prominent alkynyl glycoside used in oligosaccharide synthesis (Das, 2016). The structure (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Applications Cytidine 5’-Phosphate Methyl Ester Sodium Salt is an byproduct formed in the synthesis of analogs of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipids. References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),

Methyl a-N-acetyllactosamine is a custom synthesis of Methyl a-N-acetylgalactosamine. This compound has been modified by fluorination, methylation, and click modification to yield the desired product. The monosaccharide structure was synthesized from the corresponding glycosyl halide and protected amino acid. The glycosylation reaction between this monosaccharide and the oligosaccharide containing an unprotected hydroxyl group yields the desired product. The purity of this compound is greater than 99%.

Hyaluronate biotin is a high purity, complex carbohydrate that has been modified with methylation and glycosylation. It has a molecular weight of 20kDa and is supplied as a powder. It is a white to off-white solid that can be dissolved in water or buffer solutions. This product can be used as an excipient in the manufacture of biologics such as vaccines, antibodies, enzymes, or other therapeutic proteins.

Hyaluronate rhodamine is a fluorescent dye that is used in molecular biology to visualize the distribution of intracellular glycoconjugates. It is a water-soluble, cationic dye that binds to negatively charged saccharides and glycosaminoglycans. The dye fluoresces when bound to these molecules, making it useful for detecting the distribution of glycoproteins in cells. Hyaluronate rhodamine can be used as a marker for carbohydrate-rich tissues such as cartilage, synovial fluid, and vitreous humor. This dye can also be used to detect glycoconjugates on the surface of cells and in extracellular spaces.

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Methylation is the addition of a methyl group to a molecule. The mannobiose-BSA is a methylated derivative of mannobiose, which has been modified by adding BSA. The modification of mannobiose-BSA with BSA facilitates its use in glycosylation reactions and as an intermediate in the synthesis of other complex carbohydrates. Methylation is also used to modify saccharides, polysaccharides, and oligosaccharides. Methyl groups are typically added using an organic chemical called dimethylamine or using an enzymatic reaction with SAM-dependent methyltransferases.

A disaccharide

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

Food additive; soil suspension polymer in detergents; thickening agent

Applications Labelled Uridine, a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA) References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Grakoui, A., et al.: J. Virol., 63, 5216 (1989); Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994); Lin, Y., et al.: Virology, 292, 78 (2002);

Please enquire for more information about Difucosyllacto-N-tetraose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS, IF<br> Application: Human

1,3:1,4 b-Glucotriose (A) is a custom synthesis that is available with a purity of ≥98%. It is a fluorinated polysaccharide with a complex structure that can be modified to produce different variations. The methylation status of the compound can be customized as well. This product is an oligosaccharide and polysaccharide sugar that contains one glucose unit. It has been synthesized from the monosaccharide sugar and it can be used for chemical modification or for research purposes.