Carbohydrates and glycoconjugates

AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.

N-Acetylneuraminic acid-OVA refers to ovalbumin that has been conjugated with N-acetylneuraminic acid (Neu5Ac), a type of sialic acid. Sialic acids are important components of glycan structures and play various roles in biological processes, such as cell-cell interactions, immune response, and pathogen recognition. Conjugation of ovalbumin with N-acetylneuraminic acid can be used as a tool to study sialic acid-mediated biological phenomena or as an immunogen to elicit a specific immune response.

Applications A labelled nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. References Mullane, K., et al.: Trends Cardiovasc Med., 3, 227 (1993), Browne, G.J., et al.: J. Biol. Chem., 279, 13, 12220 (2004)

Heparin disaccharide III-A is a synthetic heparin that is modified with the addition of a sugar molecule. Heparin disaccharide III-A disodium salt (HDS) is a high purity, custom synthesized product and has been fluorinated to improve its stability. HDS has been shown to be an effective inhibitor of glycosylation in bacteria cells, leading to decreased production of bacterial enzymes and proteins. It also inhibits protein synthesis by preventing the methylation of ribosomes and reducing the number of saccharides available for glycosylation. The HDS molecule is composed of two sugars: N-acetylglucosamine and D-glucuronic acid. This compound also has anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Applications An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes. References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

Applications p-Nitrophenyl 2-Acetamido-2-deoxy-(4-O-2-acetamido-2-deoxy-β-D-_x000D_glucopyranosyl)-α-D-galactopyranoside is a compound useful in organic synthesis. References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)

Benzyl 4-O-(b-D-galactopyranosyl)-b-D-xylopyranoside is a synthetic monosaccharide that has been modified with fluorine. This compound is used to modify complex carbohydrates like glycosaminoglycans and glycoproteins. It is also used in the synthesis of oligosaccharides and polysaccharides, as well as in click chemistry. Benzyl 4-O-(b-D-galactopyranosyl)-b-D-xylopyranoside is available for custom synthesis, and can be ordered in high purity.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Fully acetylated cellohexoses, part of a polymer homologous series of oligosaccharides isolated from cellulose by acetolysis followed by chromatography.

Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: Human

Antibody Type: Rabbit Monoclonal<br> Application: ELISA, FACS<br> Application: Human