Ketones and derivatives
Ketones are organic compounds that contain a carbonyl group (C=O) bonded to two carbon atoms, forming a structure where the carbonyl group is flanked by alkyl or aryl groups. In pharmacology, ketones are used in API formulation due to their ability to enhance the solubility and stability of active ingredients. Some ketones have anti-inflammatory, analgesic, and antimicrobial properties. Ketone derivatives include compounds in which the carbonyl group is modified, such as enols, which have applications in drug synthesis and as chemical intermediates in the production of other bioactive compounds. Ketone derivatives are used in the design of new medicines, including those for treating neurodegenerative diseases, metabolic disorders, and certain types of cancer, thanks to their specific effects on enzymes and cellular processes.
Products of "Ketones and derivatives"
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Ketorolac EP Impurity I (Ketorolac USP Related Compound D)
CAS:Formula:C14H13NOColor and Shape:White To Off White SolidMolecular weight:211.262-(3-Carboxyphenyl)propionitrile (2-(3-Carboxyphenyl)propionitrile)
CAS:Nitrile function compounds, nesoiFormula:C10H9NO2Color and Shape:White Off-White SolidMolecular weight:175.063331-(3-BROMO-4-HYDROXYPHENYL)ETHANONE
CAS:Purity:95.0%Color and Shape:Liquid, No data available.Molecular weight:215.04600524902344Metamizole EP Impurity B (Ampyrone)
CAS:Formula:C11H13N3OColor and Shape:Pale Yellow SolidMolecular weight:203.25Flupirtine
CAS:Flupirtine(D 9998) is a selective neuronal potassium channel opener as well as shows properties of NMDA receptor antagonist.Formula:C15H17FN4O2Color and Shape:SolidMolecular weight:304.321-(5-Bromo-2-methylphenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:213.074005126953122-(2-Fluoro[1,1'-biphenyl]-4-yl)-2,3-dimethylbutanedioic Acid
CAS:Applications 2-(2-Fluoro[1,1'-biphenyl]-4-yl)-2,3-dimethylbutanedioic acid is an impurity of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic. Flurbiprofen impurity B. References Beaulieu, N., et al.: Drug Develop. Industrial Pharmacy, 17, 1843 (1991);Formula:C18H17FO4Color and Shape:NeatMolecular weight:316.321-(2,4-Dihydroxy-3-propylphenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:194.229995727539061-(2-Methoxy-6-((4-methoxybenzyl)oxy)phenyl)ethanone
CAS:Purity:95.0%Molecular weight:286.3269958496094rac N,O-Didesmethyl Tramadol-d3
CAS:Controlled ProductApplications A labelled metabolite of Tramadol. References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),Formula:C14H18D3NO2Color and Shape:NeatMolecular weight:238.342-Aminoindan Hydrochloride
CAS:Controlled ProductApplications Hydrochloride salt of 2-Aminoindan is an analgesic with sympathomimetic activity. 2-Aminoindan is an inhibitor norepinephrine methyltransferase. References Burn, P. et al.: J. Pharm. Pharmacol., 28, 80P (1976); Fuller, R. et al.: Biochem. Pharmacol., 26, 446 (1977);Formula:C9H11N·ClHColor and Shape:NeatMolecular weight:169.651-(3-Amino-4-bromophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:214.06199645996094Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate (Naproxen Methyl Ester)
CAS:Controlled ProductFormula:C15H16O3Color and Shape:NeatMolecular weight:244.29Azilsartan-d4
CAS:Controlled ProductApplications Labelled Azilsartan (A926900). An analgesic and antiinflammatory drugs containing angiotensin II antagonists. References Kohara, Y. et al.: J. Med. Chem., 39, 5228 (1996); Plomgaard, P. et al.: Diabetes, 54, 2939 (2005); Fenton, C. et al.: Drugs, 2005, 65, 537;Formula:C25H16D4N4O5Color and Shape:NeatMolecular weight:460.4724'-(4-Chlorophenoxy)acetophenone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:246.69000244140625(S)-O-Desmethyl Naproxen
CAS:Controlled ProductApplications A metabolite of Naproxen. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),Formula:C13H12O3Color and Shape:WhiteMolecular weight:216.23Metamizole EP Impurity C (as Hydrochloride)
CAS:Controlled ProductFormula:C12H15N3O·ClHColor and Shape:NeatMolecular weight:253.731-(2-Bromo-4-(trifluoromethyl)phenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:267.0450134277344Mesaconitine
CAS:Controlled ProductApplications An Aconitine (A189875) analog. Aconitine alkaloid pharmacokinetic analgesic. A highly poisonous, neurotoxic alkaloid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010), Yan, G., et al.: J. Pharm. Biomed. Anal., 53, 421 (2010),Formula:C33H45NO11Color and Shape:NeatMolecular weight:631.71(S)-5-Bromo Naproxen
CAS:Controlled ProductFormula:C14H13BrO3Color and Shape:NeatMolecular weight:309.161-(5-Hydroxy-2-methylphenyl)ethanone
CAS:Purity:95+%Color and Shape:SolidMolecular weight:150.177001953125Ketoprofen EP Impurity C (Ketoprofen USP Related Compound C)
CAS:Formula:C10H10O4Color and Shape:White To Off-White SolidMolecular weight:194.195'-Bromo-2'-hydroxypropiophenone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:229.0729980468751-(2,6-dimethoxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:Liquid, No data available.Molecular weight:180.20300292968751-(4-sec-Butylphenyl)ethanone
CAS:Controlled ProductApplications 1-(4-sec-Butylphenyl)ethanone is a useful synthetic intermediate in the synthesis of 2-(p-sec-Butylphenyl)propionic Acid (B692720); an impurity of Ibuprofen (I140000) which is a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)Formula:C12H16OColor and Shape:NeatMolecular weight:176.251-(2-Hydroxy-5-trifluoromethoxy-phenyl)-ethanone
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:220.147003173828124-Methoxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide
CAS:Formula:C16H15N3O4SPropyphenazone EP Impurity A (Phenazone)
CAS:Formula:C11H12N3OColor and Shape:White To Off-White SolidMolecular weight:188.231-(2-(Difluoromethoxy)phenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:186.1580047607422Piroxicam-d3
CAS:Controlled ProductApplications Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor. Clinically useful NSAID. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Carty, T.J., et al.: Prostaglandins, 47, 55 (1980), Brogden, R.N., et al.: Drugs, 22, 165 (1981), Mihalic, M., et al.: Anal. Profiles Drug Subs., 15, 509 (1986), Laneauville., O., et al.: J. Pharmacol. Exp. Ther., 271, 927 (1994),Formula:C152H3H10N3O4SColor and Shape:NeatMolecular weight:334.364-Dimethylamino Antipyrine-d6
CAS:Controlled ProductApplications Labelled 4-Dimethylaminoantipyrine(D460890). Antipyretic; analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Takahashi, T., et al.: Chem. Pharm. Bull., 6, 98 (1958), Lockwood, G.F., et al.: J. Pharm. Pharmacol., 31, 787 (1979),Formula:C13H11D6N3OColor and Shape:NeatMolecular weight:237.33Oxymorphone
CAS:Controlled ProductApplications Controlled substance (opiate). Analgesic (narcotic). References Ananthan, S., et al.: J. Med. Chem., 47, 1400 (2004), Gimbel, J., et al.: Anesth. Analg., 99, 1472 (2004), Adams, M., et al.: J. Clin. Pharmacol., 45, 337 (2005),Formula:C17H19NO4Color and Shape:White To Light BrownMolecular weight:301.344-Acetaminophen-d3 Sulfate Potassium Salt
CAS:Controlled ProductApplications 4-Acetaminophen-d3 Sulfate Potassium Salt is a deuterium labeled metabolite of Acetaminophen (A161220) (1,2,3). References (1) Lloyd, A., et al.: Biochim. Biophys. Acta., 52, 413 (1961)(2) Purohit, A., et al.: J. Steroid Biochem. Mol. Biol., 86, 423 (2003) (3) Winum, J., et al.: J. Med. Chem., 46, 2197 (2003)Formula:C8H5D3KNO5SColor and Shape:NeatMolecular weight:272.33Mefenamic Acid
CAS:Applications Anti-inflammatory; analgesic. References Winder, C.V., J. Pharmacol. Exp. Ther., 138, 405 (1962),Formula:C15H15NO2Color and Shape:Light YellowMolecular weight:241.291-(4'-Methyl-biphenyl-4-yl)-ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:210.2760009765625Nordihydro Capsaicin
CAS:Formula:C17H27NO3Color and Shape:White To Off-White SolidMolecular weight:293.411-(2-BROMO-3-CHLOROPHENYL)ETHANONE
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:233.49000549316406Ketoprofen Impurity 13
CAS:Formula:C19H20O5Color and Shape:Colourless Sticky OilMolecular weight:328.362'-Methoxypropiophenone
CAS:Purity:97.0%Color and Shape:Liquid, OilMolecular weight:164.203994750976561-(4-Amino-2-hydroxyphenyl)ethane-1-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:151.1649932861328Ibuprofen Alcohol
CAS:Controlled ProductApplications Ibuprofen Alcohol (Ibuprofen EP Impurity P) is an impurity of Ibuprofen (I140000). Ibuprofen impurity P as per EP. References Haikala, V., et al.: J. Pharm. Sci., 80, 456 (1991), Zhao, J., et al.: Anal. Chem., 72, 302 (2000), Kucera, R., et al.: J. Pharm. Biomed. Anal., 38, 609 (2005),Formula:C13H20OColor and Shape:Colourless To Light YellowMolecular weight:192.304-Methylamino antipyrine
CAS:4-Methylamino antipyrine, a Metamizole metabolite, is an analgesic and antipyretic with mild anti-inflammatory effects, also inhibits COX.Formula:C12H15N3OPurity:95.85% - 99.87%Color and Shape:SolidMolecular weight:217.27Ref: TM-T10152
10mg47.00€25mg92.00€50mg124.00€100mg187.00€200mg284.00€500mg472.00€1mL*10mM (DMSO)38.00€Acetaminophen Glucuronide Sodium Salt (Paracetamol Glucuronide Sodium Salt)
CAS:Formula:C14H16NO8·NaColor and Shape:Off-White To Pale Yellow SolidMolecular weight:326.28 22.993'-Fluoro-4'-(trifluoromethyl)acetophenone
CAS:Purity:98.0%Color and Shape:LiquidMolecular weight:206.139999389648442',5'-Dimethylpropiophenone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:162.231994628906254'-Fluoro-3'-(trifluoromethyl)acetophenone
CAS:Purity:98.0%Color and Shape:LiquidMolecular weight:206.13999938964844DAMGO
CAS:Controlled ProductStability Hygroscopic Applications DAMGO is an opioid receptor agonist (1,2). DAMGO can be used to investigate the analgesic mechanism of opioids. It has been shown that DAMGO can modulate the two-pore domain K(+) channels in the substantia gelatinosa neurons (3). References (1) Talmont, F. et al.: Peptide., 55, 79 (2014) (2) Trigub, M. et al.: Bull. Exp. Biol. Med., 156, 778 (2014) (3) Cho, P. S., et al.: Korean J Physiol Pharmacol. 20, 525 (2016)Formula:C26H35N5O6•x(C2HF3O2)Color and Shape:NeatMolecular weight:513.5911402b'-Phenyl Fentanyl
CAS:Controlled ProductApplications β'-Phenyl Fentanyl is a potent analgesic and a derivative compound of the controlled substance Fentanyl (F274990). Fentanyl Analog. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Zhu, Y., et al.: Yaoxue Xuebao, 16, 199 (1981); Zernig, G., et al.: Life Sci., 57, 2113 (1995); Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998);Formula:C28H32N2OColor and Shape:NeatMolecular weight:412.571-(2,4,5-Trichlorophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:223.479995727539061-(Pentyl-d11)-3-(4-methoxynaphthoyl)indole JWH 081-d11
CAS:Controlled ProductApplications Labelled JWH 081 (P283600). An analgesic chemical which acts as a cannabinoid agonist at the CB1 and CB2 receptors. References Huffman, J., et al.: Bioorg. Med. Chem., 11, 539 (2003), De Freitas, G., et al.: Eur. J. Med. Chem., 44, 2482 (2009),Formula:C25H14D11NO2Color and Shape:NeatMolecular weight:382.541-(3-(Benzyloxy)-4-methoxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:Liquid, No data available.Molecular weight:256.30099487304693'-Acetamidoacetophenone
CAS:Purity:95.0%Color and Shape:Solid, White to pale reddish yellow powderMolecular weight:177.2030029296875Paracetamol (Acetaminophen) EP Impurity L
CAS:Formula:C16H16N2O4Color and Shape:White To Off-White SolidMolecular weight:300.311-(2-Amino-6-bromophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:214.061996459960941-(2-Hydroxy-4,6-bis(methoxymethoxy)phenyl)ethan-1-one
CAS:Purity:98%Molecular weight:256.25399780273441-(3,4-Dimethyl-phenyl)-propan-1-one
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:162.23199462890625Dihydrocodeine-D6 Hydrochloride 0.1 mg/ml in Methanol (as free base)
CAS:Controlled ProductFormula:C182H6H17NO3·ClHFentanyl EP Impurity B
CAS:Controlled ProductFormula:C14H20N2OColor and Shape:NeatMolecular weight:232.32Acetaminophen-d3 Sulphate Potassium Salt
CAS:Formula:C8H5D3NO5S·KColor and Shape:White To Off-White SolidMolecular weight:233.23 39.10Ketorolac tromethamine salt
CAS:Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, andFormula:C19H24N2O6Purity:99.48% - 99.85%Color and Shape:CrystallineMolecular weight:376.44-Methanesulfonylacetophenone
CAS:Purity:98.0%Color and Shape:Solid, Crystalline PowderMolecular weight:198.24000549316406rac-Naproxen 2-Propyl Ester
CAS:Controlled ProductApplications rac-Naproxen 2-Propyl Ester is an impurity of Naproxen (N377520) an non-steroidal antiinflammatory agent. References Mermerian, A.H., et al.: J. Am. Chem. Soc., 127, 5604 (2005); Melgar-Fernande., et al.: Tetrahedron. Lett., 46, 1221 (2005);Formula:C17H20O3Color and Shape:NeatMolecular weight:272.345'-Bromo-2'-hydroxyacetophenone
CAS:Purity:98.0%Color and Shape:Solid, CrystallineMolecular weight:215.04600524902344Xylazine Hydrochloride
CAS:Controlled ProductFormula:C12H16N2S·ClHColor and Shape:NeatMolecular weight:256.791-(2-Fluoro-6-methylphenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:152.16799926757812Isobutyrophenone-13C6
CAS:Controlled ProductFormula:C6C4H12OColor and Shape:NeatMolecular weight:154.158d,l-trans-Tilidine.HCl.hemihydrate, 1mg/ml in Methanol (as free base)
CAS:Controlled ProductFormula:C17H23NO2·2ClH·H2ORef: 4Z-M-5323
Discontinued productButyrfentanyl
CAS:Controlled ProductFormula:C23H30N2OColor and Shape:White To Off-WhiteMolecular weight:350.505'-CYANO-2'-FLUOROACETOPHENONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:163.15100097656254-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic Acid Dihydrate (Valdecoxib Sulfonic Acid Dihydrate)
CAS:Formula:C16H13NO4S·2H2O4-Hydroxy-3-methylacetophenone
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:150.1770019531254-Acetyl-2-nitro-phenol
CAS:Purity:97.0%Color and Shape:Solid, Pale yellow to yellow green powderMolecular weight:181.14700317382812Paracetamol (Acetaminophen) EP Impurity H
CAS:Formula:C10H11NO3Color and Shape:White To Off-White SolidMolecular weight:193.204-(2-Acetyl-5-chlorophenyl)-5-methoxypyridin-2(1H)-one
CAS:Purity:98%Molecular weight:277.70001220703125Levo Mepromazine Maleate
CAS:Controlled ProductApplications The (R) optical isomer of Methotrimeprazine (M260785), an analgesic/neuroleptic. References Kandagal, P., et al.: J. Pharm. Biomed. Anal., 47, 260 (2008), Iorns, E., et al.: Biochem. J., 417, 361 (2009),Formula:C19H24N2OS·C4H4O4Color and Shape:Off-WhiteMolecular weight:444.54Ibuprofen Acyl-Beta-D-glucuronide (mixture of diastereomers)
CAS:Stability Hygroscopic, Not stable in aqueous solutions. Applications Ibuprofen Acyl-β-D-glucuronide (mixture of diastereomers) (cas# 115075-59-7) is a compound useful in organic synthesis.Formula:C19H26O8Color and Shape:NeatMolecular weight:382.403',4',5'-Trifluoropropiophenone
CAS:Purity:97.0%Color and Shape:LiquidMolecular weight:188.14900207519531-(2-Amino-4- tert -butyl-phenyl)-ethanone
CAS:Color and Shape:SolidMolecular weight:191.27400207519534'-Fluoro-2'-hydroxyacetophenone
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:154.139999389648441-(3-Bromo-2-chlorophenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:233.49000549316406Tramadol EP Impurity C HCl
CAS:Formula:C16H23NO·HClColor and Shape:Off-White SolidMolecular weight:245.37 36.46(3-Benzoylphenyl)ethanenitrile
CAS:Controlled ProductFormula:C15H11NOColor and Shape:NeatMolecular weight:221.256-Methoxy-2-naphthoic Acid
CAS:Controlled ProductImpurity Naproxen USP Related Compound A Applications An impurity of Naproxen (N377525) with bactericidal and fungicidal activity. A metabolite of Nabumetone (N200500). Naproxen USP Related Compound A. References Khorana, M.L. et al.: J. Pharmac. Sci., 56, 993 (1967); Ray, J.E. et al.: J. Chrom. Biomed. Appl., 336, 234 (1984);Formula:C12H10O3Color and Shape:Off-WhiteMolecular weight:202.21Acetaminophen-13C2, 15N1
CAS:Controlled ProductApplications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)Formula:C613C2H915NO2Color and Shape:WhiteMolecular weight:154.14Mefenamic Acid 2,3-Butylene Glycol Ester
CAS:Controlled ProductFormula:C19H23NO3Color and Shape:NeatMolecular weight:313.39(1S,2R)-1-Benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl Acetate (Acetoxyphene)
CAS:Formula:C21H27NO25'-Fluoro-2'-methoxyacetophenone
CAS:Purity:95.0%Color and Shape:Solid, Low Melting SolidMolecular weight:168.16700744628906rac 1-Methoxy Ketorolac
CAS:Controlled ProductApplications An impurity of the analgesic Ketorolac (K235650).Formula:C16H15NO4Color and Shape:NeatMolecular weight:285.293'-Fluoropropiophenone
CAS:Purity:97.00%Color and Shape:Liquid, OilMolecular weight:152.16799926757812Acetaminophen Sulphate Potassium Salt
CAS:Formula:C8H8NO5S·KColor and Shape:Off-White SolidMolecular weight:230.22 39.10
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