Ketones and derivatives
Ketones are organic compounds that contain a carbonyl group (C=O) bonded to two carbon atoms, forming a structure where the carbonyl group is flanked by alkyl or aryl groups. In pharmacology, ketones are used in API formulation due to their ability to enhance the solubility and stability of active ingredients. Some ketones have anti-inflammatory, analgesic, and antimicrobial properties. Ketone derivatives include compounds in which the carbonyl group is modified, such as enols, which have applications in drug synthesis and as chemical intermediates in the production of other bioactive compounds. Ketone derivatives are used in the design of new medicines, including those for treating neurodegenerative diseases, metabolic disorders, and certain types of cancer, thanks to their specific effects on enzymes and cellular processes.
Products of "Ketones and derivatives"
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N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide
CAS:Controlled ProductApplications N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide is an impurity of Furanylfentanyl (F864085), which is an opiod analgesic agent and an analog of Fentanyl (F275000). In addition, N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide may be a useful compound for developing fentanyl-conjugated vaccines by utilizing a protein-drug conjugate that generates an in vivo immunoantagonist, which can minimize the concentration of a specific drug at the sites of action. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bremer, P. T., et al.: Angew. Chem. Int. Ed. 55, 3772 (2016); Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998)Formula:C23H29FN2OColor and Shape:NeatMolecular weight:368.494-Chloro-3-(trifluoromethyl)acetophenone
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:222.589996337890621-(4-AMINO-2-BROMOPHENYL)ETHANONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:214.061996459960941-(4-cyclohexylphenyl)ethanone
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:202.2969970703125Flupirtine Maleate Impurity F HCl
CAS:Formula:C18H21FN4O4·HClColor and Shape:Pale Purple SolidMolecular weight:376.39 36.461-(4-Bromo-2-methoxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:229.072998046875(1RS)-1-(6-Methoxy-2-naphthyl)ethanol (Naproxen Impurity K)
CAS:Controlled ProductImpurity Naproxen EP Impurity K Applications Naproxen impurity K. References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Li, J., et al.: J. Med. Chem., 39, 1846 (1996), Monser, L., et al.: J. Pharm. Biomed. Anal., 27, 851 (2002),Formula:C13H14O2Color and Shape:White To Light YellowMolecular weight:202.25Dexketoprofen Trometamol
CAS:Controlled ProductFormula:C16H14O3·C4H11NO3Color and Shape:NeatMolecular weight:375.424'-Chloro-2'-fluoro-5'-methylacetophenone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:186.610000610351561-(5-Fluoro-2-iodophenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:264.03799438476561-[4-(Dimethylamino)phenyl]ethanone
CAS:Purity:97.0%Color and Shape:Solid, White powderMolecular weight:163.220001220703124'-Nitroacetophenone
CAS:Purity:99.00%Color and Shape:Solid, Yellow powderMolecular weight:165.14799499511724'-Hydroxyacetophenone
CAS:Purity:97.00%Color and Shape:Solid, White to almost white powderMolecular weight:136.14999389648438Trimebutine EP Impurity D
CAS:Formula:C22H29NO5Color and Shape:White To Off-White SolidMolecular weight:387.48Romifidine Hydrochloride
CAS:Controlled ProductApplications Romifidine Hydrochloride is an α2 agonist used as a sedative and analgesic (1,2). Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References (1) Nazifi, S., et al.: Res. Vet. Sci., 65, 83 (1998)(2) Celly, C., et al.: J. Vet. Pharmacol. Ther., 20, 464 (1997)Formula:C9H9BrFN3·ClHColor and Shape:WhiteMolecular weight:294.55N-Methyl-1H-indole-5-ethanesulfonamide (2-(1H-Indol-5-yl)-N-methylethanesulfonamide)
CAS:Formula:C11H14N2O2S2,3-Difluoro-4-methylacetophenone
CAS:Purity:95+%Color and Shape:LiquidMolecular weight:170.15899658203125Medetomidine Impurity 5
CAS:Formula:C20H31N3O3SSiColor and Shape:White To Off-White SolidMolecular weight:421.64Benorilate 100 µg/mL in Acetonitrile
CAS:Formula:C17H15NO5Color and Shape:Single SolutionMolecular weight:313.30Sulfaperin 100 µg/mL in Acetonitrile
CAS:Formula:C11H12N4O2SColor and Shape:Single SolutionMolecular weight:264.303',5'-Dichloroacetophenone
CAS:Purity:97.0%Color and Shape:Liquid, ClearMolecular weight:189.03999328613281-(3-Bromo-2-fluorophenyl)ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:217.03700256347656Aminophenazone (4-Dimethylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one)
CAS:Controlled ProductFormula:C13H17N3O(E)-1-(4-((4-Ethoxybenzylidene)amino)phenyl)ethan-1-one
CAS:Purity:98%Molecular weight:267.3280029296875rac N,O-Didesmethyl Tramadol
CAS:Controlled ProductApplications A metabolite of Tramadol. References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),Formula:C14H21NO2Color and Shape:NeatMolecular weight:235.323'-Nitroacetophenone
CAS:Purity:99.00%Color and Shape:Solid, Very pale yellow to pale yellow green powderMolecular weight:165.1479949951172(S,R)-N-(1-Phenylethyl) Ibuprofen Amide
CAS:Controlled ProductApplications The (S,R)-enantiomer of Ibuprofen (I140000) impurity, an anti-inflammatory compound. References Rubin, A., et al.: J. Pharm. Sci., 74, 82 (1985), Tracy, T., et al.: Drug Metab. Dispos., 20, 322 (1992),Formula:C21H27NOColor and Shape:NeatMolecular weight:309.45P-Acetylbenzenesulfonic acid sodium salt
CAS:Purity:98%Color and Shape:SolidMolecular weight:222.19000244140625Dexmedetomidine-d4 L-Tartrate (d4-Major)
CAS:Controlled ProductApplications Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic. References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)Formula:C13H12D4N2•C4H6O6Color and Shape:White To Light YellowMolecular weight:204.31150095-Benzoyl-7-bromo-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - Racemic
CAS:5-Benzoyl-7-bromo-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - Racemic is a drug product that is used for the research and development of drugs. It is manufactured synthetically. This compound has been shown to be metabolized in rats and humans. Studies have also shown that this compound may be an impurity in other drugs. The use of 5-Benzoyl-7-bromo-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid - Racemic can be found in the USP/NF as a HPLC standard or as an analytical reference standard.Formula:C15H12BrO3NPurity:Min. 95%Molecular weight:334.16 g/molMetamizole EP Impurity E
CAS:Formula:C12H15N3O4SColor and Shape:White To Off-White SolidMolecular weight:297.334'-Fluoro-3'-methoxyacetophenone
CAS:Purity:98.0%Color and Shape:Solid, Cream powderMolecular weight:168.167007446289064-[5-(2-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
CAS:Formula:C17H14F3N3O2Srac Ketoprofen-13C,d3
CAS:Controlled ProductApplications Anti-inflammatory; analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ueno, K., et al.: J. Med. Chem., 19, 941 (1976), Liversidge, G.G., Anal. Profiles Drug Subs., 10, 443 (1981), Jamali, F., et al.: Clin. Pharmacokinet., 19, 197 (1990),Formula:CC152H3H11O3Color and Shape:NeatMolecular weight:258.29(S)-5-Chloro Naproxen
CAS:Controlled ProductFormula:C14H13ClO3Color and Shape:NeatMolecular weight:264.703'-Fluoro-2'-hydroxyacetophenone
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:154.13999938964844METHYL 3-ACETYL-4-HYDROXYBENZOATE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:194.18600463867188Lofentanil Oxalate
CAS:Controlled ProductFormula:C27H34N2O7Color and Shape:NeatMolecular weight:498.571-(3-Hydroxyphenyl)propan-1-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:150.1770019531254-Acetylbenzenesulfonyl chloride
CAS:Purity:97.0%Color and Shape:Solid, Chunks or PowderMolecular weight:218.64999389648438(1RS,2SR)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Hydrochloride
CAS:Formula:C16H25NO2·ClHAcemetacin EP Impurity E
CAS:Formula:C25H26ClNO6Color and Shape:Pale Yellow SolidMolecular weight:471.93N,N-Bis(methylsulphonyl)-2-phenoxyaniline
CAS:Controlled ProductFormula:C14H15NO5S2Color and Shape:NeatMolecular weight:341.40rac Ibuprofen-d3
CAS:Controlled ProductApplications Labelled Ibuprofen, a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),Formula:C132H3H15O2Color and Shape:Off-WhiteMolecular weight:209.301-(3-Chloro-4-fluorophenyl)propan-1-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:186.61000061035156Clonidine-d4 Hydrochloride
CAS:Controlled ProductApplications α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983), Glassman, A.H., et al.: Science, 226, 864 (1984), Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992),Formula:C92H4H5Cl2N3·ClHColor and Shape:Off White SolidMolecular weight:270.58Methyl 4-Methoxybenzoate
CAS:Controlled ProductFormula:C9H10O3Color and Shape:NeatMolecular weight:166.17Medetomidine Impurity 46
CAS:Formula:C8H11NColor and Shape:White To Off-White SolidMolecular weight:121.181-(2-Amino-5-bromophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:214.061996459960943,5-Dimethylacetophenone
CAS:Purity:98.0%Color and Shape:Liquid, ClearMolecular weight:148.20500183105471-[2,4-Difluoro-3-(trifluoromethyl)phenyl]ethanone
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:224.13000488281254-Acetylphenyl isothiocyanate
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:177.220001220703121-(3-Amino-4-chlorophenyl)ethanone
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:169.610000610351564-Acetamidophenyl beta-D-Glucuronide-d3 Sodium Salt
CAS:Controlled ProductStability hygroscopic Applications 4-Acetamidophenyl β-D-Glucuronide-d3 Sodium Salt is deuterium labeled 4-Acetamidophenyl β-D-Glucuronide (A158500), a major urinary metabolite of Acetaminophen (A161220) (Paracetamol) in human (1). Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis (2,3). References (1) Johnston, D., et al.: J. Chem. Res., Synop., 12, 406 (1988)(2) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(3) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974)Formula:C14H13D3NNaO8Color and Shape:White To Light RedMolecular weight:352.29Medetomidine Impurity 20 (Hydroxymedetomidine)
CAS:Formula:C13H16N2OColor and Shape:White To Off-White SolidMolecular weight:216.281-(p-Tolyl)propan-1-one
CAS:Purity:95.0%Color and Shape:Liquid, ClearMolecular weight:148.2050018310547Trimebutine EP Impurity C (Trimethoprim EP Impurity H)
CAS:Formula:C11H14O5Color and Shape:Off-White SolidMolecular weight:226.23Ethyl 2-[2-[(2,6-Dichlorophenyl)amino]phenyl]acetate (Ethyl Ester of Diclofenac)
CAS:Formula:C16H15Cl2NO24'-BROMO-2'-FLUOROACETOPHENONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:217.03700256347656(2-Ethoxy-2-oxoethyl) 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetate
Formula:C16H19NO5Color and Shape:Neatrac-14-epi-Dextromethorphan
CAS:Controlled ProductApplications rac-14-epi-Dextromethorphan is an analog of Dextromethorphan (D299445) which is an antitussive compound showing analgesic properties. Dextromethorphan is used in cough medication formulations. References Church J., et al.: Can J Physiol Pharmacol., 67, 561 (1989); Carliss, R., et al.: Neurotoxicology., 28, 813 (2007)Formula:C18H25NOColor and Shape:NeatMolecular weight:271.403',5'-Bis(trifluoromethyl)propiophenone
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:270.17401123046875[1-(3,4-Dichlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic Acid (3,4-Dichloroindometacin)
CAS:Formula:C19H15Cl2NO44-[5-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
CAS:Formula:C17H14F3N3O3S1-(4-Bromo-3-chlorophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:233.49000549316406Ketorolac EP Impurity B (Ketorolac USP Related Compound C)
CAS:Formula:C14H11NO2Color and Shape:Yellow SolidMolecular weight:225.25Levorphanol Tartrate
CAS:Controlled ProductStability Hygroscopic Applications Levorphanol Tartrate is an orally active synthetic morphine analog. Analgesic (narcotic). Controlled substance. References Randall, L.O., et al.: J. Pharmacol. Exp. Ther., 99, 163 (1950), Dajani, E., et al.: Eur. J. Pharmacol., 34, 105 (1975), Winpenny, J., et al.: Drugs, 8, 416 (2005),Formula:C17H23NO•C4H6O6Color and Shape:NeatMolecular weight:257.37150091-(5-(Benzyloxy)-2-hydroxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:242.2740020751953Amfenac Ethyl Ester
CAS:Controlled ProductFormula:C17H17NO3Color and Shape:NeatMolecular weight:283.32Fentanyl-d5
CAS:Controlled ProductApplications Used as an analgesic. Controlled substance Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998),Formula:C222H5H23N2OColor and Shape:White To Off-WhiteMolecular weight:341.50Bornyl Acetate
CAS:Applications Bornyl Acetate (Mixture of Diastereomers) is a monoterpene ester, and also the main, natural constituent of valerian root oil. Bornyl acetate also has analgesic and anti-inflammatory properties. References Buchbauer, G., et al.: Die Pharm., 47, 620 (1992); Oh, H., et al.: Appl. Micro., 15, 777 (1967); Wu, X., et al.: J. Chinese Med. Mat., 27, 438 (2004)Formula:C12H20O2Color and Shape:NeatMolecular weight:196.29Alpha-(4-Isobutylphenyl)ethanol
CAS:Applications The photodegradation product of Ibuprofen (I140000). Shows cytotoxicity activity. References Kobayashi, S., et al.: Biochemistry, 23, 4589 (1984), Karthein, R., et al.: Eur. J. Biochem., 171, 313 (1988), Maranon, M., et al.: Phytochem., 37, 1217 (1994),Formula:C12H18OColor and Shape:Colourless LiquidMolecular weight:178.27Methyl 3-acetyl-4-aminobenzoate
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:193.20199584960938
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