Ketones and derivatives
Ketones are organic compounds that contain a carbonyl group (C=O) bonded to two carbon atoms, forming a structure where the carbonyl group is flanked by alkyl or aryl groups. In pharmacology, ketones are used in API formulation due to their ability to enhance the solubility and stability of active ingredients. Some ketones have anti-inflammatory, analgesic, and antimicrobial properties. Ketone derivatives include compounds in which the carbonyl group is modified, such as enols, which have applications in drug synthesis and as chemical intermediates in the production of other bioactive compounds. Ketone derivatives are used in the design of new medicines, including those for treating neurodegenerative diseases, metabolic disorders, and certain types of cancer, thanks to their specific effects on enzymes and cellular processes.
Products of "Ketones and derivatives"
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1-(3-Hydroxy-2-nitrophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:181.14700317382812Tramadol Impurity 7 HCl
Formula:C16H25NO3·HClColor and Shape:White To Off-White SolidMolecular weight:279.38 36.463-Chloro-4-hydroxyacetanilide
CAS:3-Chloro-4-hydroxyacetanilide is a chemical compound that belongs to the class of acetanilides. It has long-term toxicity and is used as a drug substance in the production of aniline derivatives. 3-Chloro-4-hydroxyacetanilide has been shown to be carcinogenic in hamsters. The long term exposure to this chemical was shown to cause liver damage and increased incidence of tumours in rats. This drug also contains impurities and traces of chloride, chlorine, and thionyl chloride, which are toxic substances that can cause irritation or burns on contact with skin or eyes.Formula:C8H8ClNO2Purity:Min. 95%Molecular weight:185.61 g/mol4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
CAS:Formula:C17H14F3N3O2S(±)-Ibuprofen Methyl Ester
CAS:Controlled ProductApplications (±)-Ibuprofen Methyl Ester is a phototoxic, photoproduct of Ibuprofen (I140000), a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. Ibuprofen is also used as an anti-inflammatory drug. References Miranda, M.A., et. al.: Toxicol. In Vitro, 5, 451 (1991); Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)Formula:C14H20O2Color and Shape:ColourlessMolecular weight:220.313-Cysteinylacetaminophen-D5 (major), Trifluoroacetic Acid Salt
CAS:Controlled ProductApplications 3-Cysteinylacetaminophen-D5 (major), Trifluoroacetic Acid Salt is deuterium labeled 3-Cysteinylacetaminophen Trifluoroacetic Acid Salt (C994750), which is a metabolite of Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).Minimum isotopic incorporation d-3, no d-0 present. A representative lot has 64% isotopic incorporation at the 6-position, 89% at the 4-position. References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)Formula:C11H9D5N2O4S•C2HF3O2Color and Shape:NeatMolecular weight:389.36Salsalate
CAS:Impurity Acetylsalicylic Acid EP Impurity E (Aspirin EP Impurity E) Applications Nonacetylated aspirin analog. Analgesic, anti-inflammatory. Acetylsalicylic Acid Impurity E (Aspirin Impurity E) Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980), Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),Formula:C14H10O5Color and Shape:Off-WhiteMolecular weight:258.236-Methoxynaphthalene-2-carboxylic Acid (6-Methoxy-2-naphthoic Acid; 2-Carboxy-6-methoxynaphthalene)
CAS:Controlled ProductFormula:C12H10O3Color and Shape:NeatMolecular weight:202.213'-Hydroxy-4'-methoxyacetophenone
CAS:Purity:98.0%Color and Shape:Solid, No data available.Molecular weight:166.175994873046883'-Chloro-4'-methylacetophenone
CAS:Purity:97.0%Color and Shape:Liquid, OilMolecular weight:168.6199951171875POTASSIUM (4-ACETYLPHENYL)TRIFLUOROBORATE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:226.05000305175782',4'-Difluoro-3'-methoxyacetophenone
CAS:Purity:98.0%Color and Shape:LiquidMolecular weight:186.1580047607422Ref: 4Z-M-68102
Discontinued product2-(p-sec-Butylphenyl)propionic Acid
CAS:Controlled ProductImpurity Ibuprofen EP Impurity O Applications 2-(p-sec-Butylphenyl)propionic Acid (Ibuprofen EP Impurity O) is an impurity of Ibuprofen (I140000); a selective cyclooxygenase inhibitor (IC50=14.9uM) that inhibits PGH synthase-1 and PGH synthase-2 with comparable potency. References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)Formula:C13H18O2Color and Shape:NeatMolecular weight:206.28rac-Acetaminophen Mercapturate-d5 (Major)
CAS:Controlled ProductApplications rac-Acetaminophen Mercapturate-d5 (Major), is a labeled analogue and free acid of 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen Disodium Salt (A172100), which is a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3). References van der Hooft, J.,et al.: Metabolomics, 12, 1 (2016)Formula:C13H11D5N2O5SColor and Shape:NeatMolecular weight:317.374-Hydroxy-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide
CAS:Controlled ProductFormula:C14H11N3O4SColor and Shape:NeatMolecular weight:317.32Ketoprofen EP Impurity A (Ketoprofen USP Related Compound D)
CAS:Controlled ProductFormula:C15H12O2Color and Shape:NeatMolecular weight:224.251-(5-Bromo-2-nitro-phenyl)ethanone
CAS:Purity:98.0%Color and Shape:Solid, NeedlesMolecular weight:244.044006347656251-(4-(Benzyloxy)-3-methoxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:256.3009948730469Firocoxib
CAS:Applications A selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory; analgesic. References McCann, M.E., et al.: Am. J. Vet. Res., 65, 503 (2004),Formula:C17H20O5SColor and Shape:Off-WhiteMolecular weight:336.404'-(3-Fluorobenzyloxy)acetophenone
CAS:Purity:99.0%Color and Shape:SolidMolecular weight:244.26499938964844Ketoprofen EP Impurity H
CAS:Formula:C9H7NO2Color and Shape:White To Off-White SolidMolecular weight:161.16(R)-(-)-Ketoprofen
CAS:Controlled ProductApplications Anti-inflammatory; analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ueno, K., et al.: J. Med. Chem., 19, 941 (1976), Liversidge, G.G., Anal. Profiles Drug Subs., 10, 443 (1981), Jamali, F., et al.: Clin. Pharmacokinet., 19, 197 (1990),Formula:C16H14O3Color and Shape:NeatMolecular weight:254.282',4'-Dimethylpropiophenone
CAS:Purity:95.0%Color and Shape:Solid, No data available.Molecular weight:162.23199462890625Medetomidine hydrochloride
CAS:Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.Formula:C13H16N2·HClPurity:99.96%Color and Shape:White Or Off White Crystalline PowderMolecular weight:236.741-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:246.110000610351562'-Nitroacetophenone
CAS:Purity:97.0%Color and Shape:Liquid, Clear LiquidMolecular weight:165.1479949951172(S)-(+)-Ibuprofen 2-(Benzyloxy)propan-1-yl Ester
Controlled ProductApplications (S)-(+)-Ibuprofen 2-(Benzyloxy)propan-1-yl Ester is an intermediate in the synthesis of (S)-(+)-Ibuprofen Propylene Glycol Ester (I140100), a derivative of (S)-(+)-Ibuprofen (I140010), a nonsteroidal anti-inflammatory drug (NSAID). References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),Formula:C23H30O3Color and Shape:NeatMolecular weight:354.4832-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic Acid (1-Hydroxyibuprofen)
CAS:Controlled ProductFormula:C13H18O3Color and Shape:NeatMolecular weight:222.28(R)-3-(4-acetylphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
CAS:Purity:98%Molecular weight:307.34600830078125N-(4-Hydroxyphenyl)acetamide sulfate-d3 sodium
CAS:Controlled ProductPlease enquire for more information about N-(4-Hydroxyphenyl)acetamide sulfate-d3 sodium including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormula:C8H6D3NO5S•NaPurity:Min. 95%Molecular weight:257.24 g/molN-Acetyl-N-phenyl-2,6-dichloroaniline
CAS:Controlled ProductFormula:C14H11Cl2NOColor and Shape:NeatMolecular weight:280.15Racemorphan Hydrobromide
CAS:Controlled ProductStability Hygroscopic Applications (±)-17-Methyl-morphinan-3-ol Hydrobromide is a racemic mixture of Dextrorphan Tartrate Salt (D299485) and Levorphanol Tartrate (L376500). Dextrorphan Tartrate Salt and Levorphanol Tartrate are orally active synthetic morphine analogs and analgesics (narcotic). Levorphanol Tartrate is a controlled substance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tallarida, R., et al.: Life Sci., 45, 947 (1989); Netzer, R., et al.: Eur. J. Pharmacol., 238, 209 (1993); Mao, J., et al.: Pain, 67, 361 (1996); Chow, L., et al.: J. Biomed. Sci., 11, 717 (2004); Randall, L.O., et al.: J. Pharmacol. Exp. Ther., 99, 163 (1950); Dajani, E., et al.: Eur. J. Pharmacol., 34, 105 (1975); Winpenny, J., et al.: Drugs, 8, 416 (2005),Formula:C17H24BrNOColor and Shape:NeatMolecular weight:338.284'-BROMO-2',3'-DIFLUOROACETOPHENONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:235.02799987792973'-Chloro-4'-fluoroacetophenone
CAS:Purity:97.0%Color and Shape:Solid, PowderMolecular weight:172.58000183105474'-Methylacetophenone
CAS:Purity:99.0%Color and Shape:Liquid, ClearMolecular weight:134.177993774414062',6'-Difluoroacetophenone
CAS:Purity:97.0%Color and Shape:Liquid, ClearMolecular weight:156.1320037841797Acetanilide-d5 (Acetylaniline-d5)
CAS:Controlled ProductApplications The first aniline derivative found to possess analgesic and antipyretic properties. References Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Chang, C., et al.: J. Nat. Prod., 73, 229 (2010),Formula:C82H5H4NOColor and Shape:NeatMolecular weight:140.19Tapentadol-d5 Hydrochloride
CAS:Controlled ProductApplications A novel, centrally acting oral analgesic with a dual mode of action that has demonstrated efficacy in preclinical and clinical models of pain relief. References Boxenbaum, H., et al.: J. Pharm. Sci., 2, 47 (1999), Boase, S., et al.: Br. J. Clin. Pharmacol., 54, 493 (2002), Armstrong, S., et al.: Psychosomatics, 44, 515 (2003), Bjornsson, T., et al.: Drug Metab. Dispos., 31, 815 ( 2003),Formula:C14H19D5ClNOColor and Shape:NeatMolecular weight:262.83Methyl [[[2-[(2,6-Dichlorophenyl)amino]phenyl]acetyl]oxy]acetate (Methyl Ester of Aceclofenac)
CAS:Formula:C17H15Cl2NO43'-Amino-2'-hydroxyacetophenone
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:151.1649932861328Cyclohexanone, 99+%
CAS:Cyclohexanone is used in the preparation of synthetic polymer such as nylon 6,6 and nylon 6. It acts as a solvent in organic synthesis. Its derivatives are used for the synthesis of dyes, rubber chemicals, plasticizers and pharmaceuticals. Further, it is involved in the preparation of cyclohexanone oxime, which rearranges to give caprolactam in the presence of sulfuric acid catalyst. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C6H10OPurity:99+%Color and Shape:Clear colorless, LiquidMolecular weight:98.154'-Chloropropiophenone
CAS:Purity:99.00%Color and Shape:Solid, White to very pale yellow powderMolecular weight:168.6199951171875Cyclohexanone, ACS, 99+%
CAS:Cyclohexanone is used as an industrial solvent and paint remover. It acts as a precursor to nylon 6,6 and nylon 6 and cyclohexanone oxime, which gives caprolactam on rearrangement. Further, it is used as a chemical reaction medium, adhesives, sealants and agricultural products. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C6H10OPurity:99+%Molecular weight:98.15Desomorphine-d3
CAS:Controlled ProductApplications Labelled Desomorphine (D296900). Analgesic (narcotic). Controlled substance (opium derivative). References Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007), Zhao, M., et al.: Eur. J. Med. Chem., 43, 1048 (2008), Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009),Formula:C172H3H18NO2Color and Shape:NeatMolecular weight:274.37Nabumetone dimer
CAS:Nabumetone is a nonsteroidal anti-inflammatory drug that is metabolized by the liver to form a dimer. The major metabolite of nabumetone is the dimer, which has been used as an impurity standard for this drug. Nabumetone has been shown to inhibit prostaglandin synthesis, and its metabolites have been studied for their effects on various enzymes.Formula:C27H26O3Purity:Min. 95%Molecular weight:398.49 g/mol3',5'-Dimethyl-4'-methoxyacetophenone
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:178.23100280761722',6'-Difluoropropiophenone
CAS:Purity:97.0%Color and Shape:LiquidMolecular weight:170.15899658203125(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-acetylphenyl)propanoic acid
CAS:Purity:98%Molecular weight:429.47198486328125Dexibuprofen 1,2,3-Propanetriol Esters (Mixture of Regio- and Stereoisomers)
Controlled ProductFormula:C16H24O4Color and Shape:MixtureMolecular weight:560.721-(3-BROMO-2-HYDROXY-5-METHYLPHENYL)ETHANONE
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:229.072998046875Betameprodine Hydrochloride
CAS:Controlled ProductApplications Narcotic analgesic. The β-analogue of Proline (P755300). References Iorio, M.A., et al.: J. Med. Chem., 20, 309 (1977),Formula:C17H25NO2·ClHColor and Shape:Off-WhiteMolecular weight:311.85Levomedetomidine HCl
CAS:Formula:C13H16N2·HClColor and Shape:White To Off-White SolidMolecular weight:200.29 36.46N-Phenylacetamide (Acetanilide)
CAS:Controlled ProductFormula:C8H9NOColor and Shape:NeatMolecular weight:135.161-(4-(Phenylethynyl)phenyl)ethan-1-one
CAS:Purity:95+%Color and Shape:SolidMolecular weight:220.270996093753,5-Dibromo-4-hydroxyacetophenone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:293.94198608398441-(4-Isopropoxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:Liquid, No data available.Molecular weight:178.2310028076172Metamizole EP Impurity C HCl
CAS:Formula:C12H15N3O·HClColor and Shape:Off-White SolidMolecular weight:217.27 36.463'-Acetyl-biphenyl-2-carboxylic acid
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:240.257995605468751-(4-Amino-2-methoxyphenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:165.192001342773441-(2-Amino-5-fluorophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:153.1560058593751-(4-(4-Acetyl-2-fluorophenyl)piperazin-1-yl)-2-chloroethan-1-one
CAS:Purity:98%Molecular weight:298.739990234375(S)-1-(4-(1-Aminoethyl)phenyl)ethanone hydrochloride
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:199.679992675781251-(4-Difluoromethoxy-phenyl)-ethanone
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:186.1580047607422Oxyphenbutazone Monohydrate
CAS:Controlled ProductFormula:C19H20N2O3·H2OColor and Shape:NeatMolecular weight:342.392'-Methoxy-5'-(trifluoromethyl)acetophenone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:218.17500305175781-(4-Amino-3-bromophenyl)ethanone
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:214.061996459960941-Pentyl-3-(4-ethyl-naphthoyl)indole JWH 210
CAS:Controlled ProductApplications An analgesic chemical which acts as a cannabinoid agonist at the CB1 and CB2 receptors. References Tuccinardi, T., et al.: J. Med. Chem., 49, 984 (2006), Rituparna, S., et al.: Lett. Drug Des. Discov., 6, 599 (2009), De Freitas, G., et al.: Eur. J. Med. Chem., 44, 2482 (2009),Formula:C26H27NOColor and Shape:NeatMolecular weight:369.50Nordihydrocapsaicin
CAS:Nordihydrocapsaicin is an analog and congener of capsaicin, belonging to the capsaicinoid class of compounds found in Capsicum chili peppers.Formula:C17H27NO3Purity:99.59% - 99.77%Color and Shape:SolidMolecular weight:293.42'-Chloro-5'-nitroacetophenone
CAS:Purity:97.0%Color and Shape:SolidMolecular weight:199.58999633789062Paracetamol EP Impurity A (Acetaminophen USP Related Compound C)
CAS:Formula:C8H9NO2Color and Shape:Brown SolidMolecular weight:151.17Ketoprofen Propylene Glycol Ester (Mixture of Isomers)
Formula:C19H20O4Color and Shape:Colorless LiquidMolecular weight:312.37Isopropyl [2-[(2,6-Dichlorophenyl)amino]phenyl]acetate (Isopropyl Ester of Diclofenac)
CAS:Formula:C17H17Cl2NO2Paracetamol (Acetaminophen) EP Impurity J (Acetaminophen USP Related Compound J)
CAS:Formula:C8H8ClNOColor and Shape:White To Off-White SolidMolecular weight:169.61Lornoxicam
CAS:Controlled ProductApplications Cyclooxygenase inhibitor; structurally similar to Tenoxicam. Anti-inflammatory; analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ankier, S.I., et al.: Postgrad. Med. J., 64, 752 (1988), Tricerri, M., et al.: Chem. Phys. Lipids, 71, 61 (1994), Santos, N., et al.: Biochemistry, 37, 8674 (1998), Pellicano, A., et al.: Infect. Immun., 75, 1738 (2007),Formula:C13H10ClN3O4S2Color and Shape:Yellow Crystalline PowderMolecular weight:371.823-Acetylphenyl isothiocyanate
CAS:Purity:98.0%Color and Shape:Solid, Low Melting SolidMolecular weight:177.22000122070312
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