Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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5-Chloro Acesulfame
CAS:Controlled ProductImpurity Acesulfame Potassium Impurity B Applications 5-Chloro Acesulfame, is an impurity of Acesulfame (A132500), the artificial sweetener, and a new sweet-tasting oxathiazinone dioxides. Acesulfame Potassium Impurity B References Clauss, K., et al.: Liebigs Annalen der Chemie,4, 494 (1980); Armenta, S., et al.: J. Agric. Food Chem., 52, 7798 (2004);Formula:C4H4ClNO4SColor and Shape:NeatMolecular weight:197.602-[(4-chloro-2,3,5,6-tetradeuteriobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid
CAS:Formula:C19H15ClN2O4Purity:%Color and Shape:SolidMolecular weight:370.7864Quetiapine Impurity-N
CAS:Controlled ProductImpurity Quetiapine EP Impurity N Stability Hygroscopic Applications Quetiapine Impurity-N (Quetiapine EP Impurity N) is a metabolite of Quetiapine, which is approved for the treatment of schizophrenia, bipolar disorder, and along with an antidepressant to treat major depressive disorder. References Onrust, S., et al.: CNS Drugs, 15, 329 (2001), Lin, S., et al.: J. Anal. Toxicol., 28, 443 (2004), Kirschbaum, K., et al.: Clin. Chem., 51, 1718 (2005), Kinon, B., et al.: J. Clin. Psychopharmacol., 26, 453 (2006),Formula:C29H41N5O3SColor and Shape:Light YellowMolecular weight:539.737-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene
CAS:Applications Raloxifene Impurity I.Formula:C42H44N2O6SColor and Shape:Yellow SolidMolecular weight:704.87363-Azetidinecarboxylic acid, methyl ester, hydrochloride (1:1)
CAS:Formula:C5H10ClNO2Purity:95%Color and Shape:SolidMolecular weight:151.5914Gallamine triethiodide
CAS:Formula:C30H60I3N3O3Purity:98%Color and Shape:SolidMolecular weight:891.5291(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone
CAS:Formula:C9H9NO2Purity:>98.0%(HPLC)(N)Color and Shape:White to Light yellow powder to crystalMolecular weight:163.18Crisaborole-d4
CAS:Formula:C14H6D4BNO3Color and Shape:White To Off-White SolidMolecular weight:255.07(S)-Alpha-Hydroxy-Beta-methoxy-Beta-phenyl-benzenepropanoic Acid Methyl Ester
CAS:Controlled ProductImpurity Ambrisentan Hydroxyester Impurity Applications (S)-α-Hydroxy-β-methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester is an impurity in the synthesis of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive. (Ambrisentan Hydroxyester Impurity) References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),Formula:C17H18O4Color and Shape:NeatMolecular weight:286.324,4'-Dimethylbenzhydrol
CAS:Formula:C15H16OPurity:>98.0%(GC)Color and Shape:White to Almost white powder to crystalMolecular weight:212.29Cariprazine Impurity 1 (sulfate salt)
Formula:C18H27Cl2N3·5(H2SO4)Molecular weight:356.34 : 1.5(98.07)N-Desethyl Sunitinib-d5
CAS:Controlled ProductApplications A labelled metabolite of Sunitinib (S820000). References Sun, L., et al.: J. Med. Chem., 46, 1116 (2003), Mendel, D.B., et al.: Clin. Cancer Res., 9, 327 (2003), Sistla, A., et al.: Drug Dev. Ind. Pharm., 30, 19 (2004), Sakamoto, K.M., et al.: Curr. Opin. Invest. Drugs, 5. 1329 (2004),Formula:C20H18D5FN4O2Color and Shape:NeatMolecular weight:375.451H-1-Ethyl Candesartan Cilexetil
CAS:Controlled ProductImpurity Candesartan Cilexetil EP Impurity E Applications 1H-1-Ethyl Candesartan Cilexetil (Candesartan Cilexetil EP Impurity E) is an impurity of Candesartan Cilexetil (PHARMEUROPA). References Cagigal, E., et al.: J. Chromatogr., 26, 477 (2001), Bakshi, M., et al.: J. Pharm. Biomed. Anal., 28, 1011 (2002),Formula:C35H38N6O6Color and Shape:NeatMolecular weight:638.71(3a)-Allopregnanolone Sulfate Pyridinium Salt
CAS:Controlled ProductApplications (3α)-Allopregnanolone Sulfate is the sulfate conjugate of (3α)-Allopregnanolone (A547100), a metabolite of progesterone and potent positive modulator of GABAA receptors. References El-Etr, M. et al.: Brain Res., 790, 334 (1998); Hauser, C.A.E. et al.: Eur. J. Pharmacol. Mol. Pharmacol. Sec., 289, 249 (1995);Formula:C26H39NO5SColor and Shape:White To Off-WhiteMolecular weight:477.66Fludrocortisone-d5
CAS:Formula:C21H24D5FO5Color and Shape:White To Off-White SolidMolecular weight:385.49Homovanillyl Alcohol Sulfate Sodium Salt
CAS:Formula:C9H11O6S·NaColor and Shape:White To Off-White SolidMolecular weight:247.25 22.99N-Ethyl-N'-nitro-N-nitrosoguanidine (Technical Grade)
CAS:Controlled ProductFormula:C3H7N5O3Color and Shape:NeatMolecular weight:161.119N-Desethyl Metoclopramide
CAS:Formula:C12H18ClN3O2Color and Shape:Pale Yellow SolidMolecular weight:271.75Dicarbonic acid, 1,3-di-2-propen-1-yl ester
CAS:Formula:C8H10O5Purity:95%Color and Shape:LiquidMolecular weight:186.162Doxepin Glucuronide (Mixture of Z and E Isomers)
CAS:Formula:C25H29NO7Color and Shape:White To Off-White SolidMolecular weight:455.5125-Desacetyl Rifapentin-d8
CAS:Controlled ProductFormula:C45H54D8N4O11Purity:>90%Color and Shape:NeatMolecular weight:843.04Gemcitabine Triphosphate Tri(triethylamine) Salt
CAS:Formula:C9H14F2N3O13P3(C6H15N)Molecular weight:503.17 : 3(101.19)Vitamin B5-d4 Calcium Salt
CAS:Formula:C9H12D4NO5·CaColor and Shape:White To Off-White SolidMolecular weight:2*222.25 40.08N-(2-Cyanoethyl)glycine
CAS:Formula:C5H8N2O2Purity:>98.0%(T)Color and Shape:White to Almost white powder to crystalMolecular weight:128.134,5-Dehydro-Capsaicin
CAS:Controlled ProductApplications (4E,6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnona-4,6-dienamide is a impurity of Capsaicin (C175680) which has been isolated from paprika and cayenne. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. References Molnar, et al.: Arzneim.-Forsch., 15, 718 (1965), Monsereenusorn,Y., et al.: Crit. Rev. Toxicol., 10, 321 (1982),Formula:C18H25NO3Color and Shape:Colourless To Light BrownMolecular weight:303.4Sesamin
CAS:Formula:C20H18O6Purity:>98.0%(GC)Color and Shape:White to Almost white powder to crystalMolecular weight:354.36Thiamphenicol
CAS:Formula:C12H15Cl2NO5SPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:356.214,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxylic Acid Methyl Ester
CAS:Controlled ProductFormula:C26H26N4O5Color and Shape:NeatMolecular weight:474.5084-Isopropylphenol
CAS:Impurity Propofol EP Impurity H Applications 4-Isopropylphenol (Propofol EP Impurity H) is an impurity of Propofol (P829750). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),Formula:C9H12OColor and Shape:WhiteMolecular weight:136.19Norfluoxetine-d5 Hydrochloride
CAS:Controlled ProductApplications A labelled metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant. References Wong, D., et al.: J. Pharmacol. Exp. Ther., 193, 804 (1975), Thorsen, T., et al.: J. Cancer Clin. Oncol., 18, 333 (1982), Howell, A., et al.: Lancet, 365, 60 (2005),Formula:C162H5H11F3NO·ClHColor and Shape:Light BrownMolecular weight:336.797-[4-[4-(3-Chlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydroquinolin-2(1H)-one
CAS:Formula:C23H28ClN3O2(2Z)-7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid
CAS:Controlled ProductStability Hygroscopic Applications (2Z)-7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid is a reagent used in the preparation of Cilastatin (C441105), prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct. References Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983), Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983), Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983),Formula:C13H20ClNO3Color and Shape:NeatMolecular weight:273.76All-rac-alfa-Tocopheryl Acetate EP Impurity D (Mixture of Isomers)
CAS:Formula:C32H45O3Molecular weight:486.79Sulindac EP Impurity C-d3 (Sulindac USP Related Compound C-d3, Sulindac Sulfide-d3)
CAS:Formula:C20H14D3FO2SColor and Shape:Yellow SolidMolecular weight:343.43Quinapril Ethyl Ester Maleic Acid Salt
CAS:Controlled ProductApplications An impurity of Quinapril (Q670000), an angiotensin converting enzyme (ACE) inhibitor. References Klutchko, S. et al.: J. Med. Chem., 29, 1953 (1986);Formula:C31H38N2O9Color and Shape:NeatMolecular weight:582.64Riociguat EP Impurity A-d4 (N-Desmethyl Riociguat-d4)
CAS:Formula:C19H13D4FN8O2Molecular weight:412.42
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