Phthalate Standards

Applications Decyl Hexyl Phthalate is an phthalate esters used as plasticizers and additives. Used in toxiciology studies as well as risk assessment studies of food contamination that occurs via migration of phthalates into foodstuffs from food-contact materials (FCM). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Awad, N.E., et al.: Bull. Factul. Pharma., 40, 233 (2002); Harris, C.A., et al.: Environ. Health. Perspect., 105, 802 (1997);

Applications Phosphoric Acid Tris(2-​methylphenyl) Ester is a metabolic precursor to neuropathy target esterase (NTE) inhibitors. It is also a flame retardant and plasticizer in marine fish and human milk. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Li, W., et al.: Toxicol. Lett., 98, 139 (1998); Sundkvist, A., et al.: J. Environ. Monitoring, 12, 943 (2010)

Applications Isophthalic-2,4,5,6-d4 Acid (CAS# 148472-48-4) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications An oxidative metabolite of Bis(2-ethylhexyl)phthalate (DEHP) (B433850), as biomarker for human exposure assessment. References Gray, T., et al.: Toxicol. Lett., 11, 141 (1982), Albro, P., et al.: Drug Metab. Rev., 21, 13 (1989), Gray, L., et al.: Toxicol. Sci., 58, 350 (2000),

Applications Labelled Dicyclohexyl Phthalate (DCHP) metabolite. References Okubo, T., et al.: Biol. Pharm. Bull., 26, 1219 (2003), Silva, M., et al.: J. Anal. Toxicol., 29, 819 (2005), Matsumoto, M., et al.: Reg. Toxicol. Pharmacol., 50, 37 (2008),

Applications 2-(((4-Methyl-7-oxyooctyl)oxy)carbonyl)cyclohexanecarboxylic Acid is a secondary oxidized metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH) and may be used as biomarkers of DINCH exposure. DINCH is a major substitute for some high molecular weight phthalates that adversely affect reproductive function. References Schutze, A., et. al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 895, 123 (2012)

Stability Hygroscopic Applications A glucuronide conjugate of the phthalate ester metabolite Monomethyl Phthalate (M566540). References Thompson, R.M. et al.: Drug Metab. Disp., 1, 489 (1973);

Applications A phthalate labelled metabolite with genotoxic effect. References Reyes, F., et al.: J. Clin. Endocrinol. Metab., 37, 74 (1973), Engel, S., et al.: Neurotoxicology, 30, 522 (2009),

Applications isotope labelled Dibenzyl Phthalate is an plasticizer used in toys that was found to exhibit potential estrogen agonist/ antagonist properties. References Zhang, Z.B., et al.: Toxicol. Lett., 207, 7 (2011); Mentlein, R., et al.: BIochem. Pharma., 38, 3126 (1989);

Applications Phthalic Acid-d4 Mono-tetrahydrogeranyl Ester is the isotope analog of Phthalic Acid Mono-tetrahydrogeranyl Ester. Phthalic Acid Mono-tetrahydrogeranyl Ester is used in biological studies for the determination of total phthalates in urine by isotope-dilution liquid chromatography tandem-mass spectrometry of phthalic acid in human urine after acid hydrolysis of metabolite mixture. References Kat0, K., et al.: J. Chromaogr., B: Anal. Technol. Biomed. Life Sci., 814, 355

Stability Moisture Sensitive Applications 2-Isopropylphenyl Diphenyl Phosphate is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);

Applications Labelled Benzyl Butyl Phthalate (B233555). A phthalate metabolite with genotoxic effect. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Reyes, F., et al.: J. Clin. Endocrinol. Metab., 37, 74 (1973), Engel, S., et al.: Neurotoxicology, 30, 522 (2009),

Applications 3-Oxo-12a-hydroxy-5β-cholanoic Acid is a keto bile acid derivative. References Bortolini, O. et al.: Tetra., 62, 4482 (2006); Bortolini, O. et al.: J. Org. Chem., 67, 5802 (2002);

Applications Dimethyl Terephthalate-2,3,5,6-d4 (CAS# 74079-01-9) is a useful isotopically labeled research compound.