Environmental Regulatory Standards

Applications N-Desmethylthiamethoxam-D4 is an impurity of thiamethoxam and an isotope labelled compound of N-Desmethylthiamethoxam (D292485). Thiamethoxam is a hepatotoxic insecticide in mice. References Swenson, T. L., et al.: Toxicol. Lett., 216, 139 (2013); Karmakar, R., et al.: Pest Manag. Sci, 65, 931 (2009)

Applications A thiol reactive fluorescent probe for the labelling of proteins. Rhodamine dyes are used extensively in various aspects of fluorescence microscopy because of their brightness and resistance to photobleaching. They are valuable in studies directed at probing changes in orientation and mobility of proteins using fluorescence anisotropy measurements. It is a mixture of the 6-Iodo and 6-chloro. References Corrie, J.E.T., and Craik, J.S.: J. Chem. Soc. Perkin Trans. 1, 2967 (1994)

Applications Coumarin anticoagulant. Marketed as the racemate; the S-(-)-form is the more potent isomer. Anticoagulant. This compound is a contaminant of emerging concern (CECs). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),

Stability Moisture Sensitive Applications Used as flame retardant for PPE, ABS and PET resins. It is very suitable for used in engineering plastic because of the low volatile and high heat resistance. Phosphorus Flame Retardant. References Braun, U., et al.: Polym. Degrad. Stab., 92, 1528 (2007), Horrocks, A., et al.: J. Fire Sci., 27, 495 (2009),