Amino Acids (AA)

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N-Fmoc-L-pipecolinic acid is a tripeptide that is an antagonist of oxytocin. It has been shown to have a high reactivity in the solid phase synthesis, and can be assembled on a solid support such as polystyrene via the Fmoc chemistry. The active ester is synthesized by reacting fmoc-l-pipecolic acid with acid chlorides in sequential steps. The reagents used are chloroacetic acid, N,O-dimethylhydroxylamine hydrochloride, and dimethylaminopyridine. This product also has a high reactivity with other acids such as hexapeptide.

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4-Fluoro-DL-phenylglycine is an analog of dopamine that is metabolized to fusogenic amino acids. It is also a substrate for aminotransferases and dehydrogenase enzymes. 4-Fluoro-DL-phenylglycine has been shown to increase reaction time in animals, which may be due to its ability to inhibit the production of dopamine. Furthermore, this compound exhibits antimicrobial properties against Gram-positive bacteria. The biological function of 4-fluoro-DL-phenylglycine includes the regulation of trifluoroacetic acid levels in the brain, which may be related to its effects on dopamine.

Applications Cyclic propano guanine adduct DNA acetaldehyde histone. References Nath, R., et al.: Cancer Res., 58, 581 (1998), Wang, M., et al.: Chem. Res., 13, 1065 (2000), Terashima, I., et al.: Biochemistry, 40, 4106 (2001), Yokoyama, A., et al.: Carcinogenesis, 23, 1851 (2002),

Ethyl 3-phenyl-1H-pyrazole-5-carboxylate is a synthetic molecule that is used to synthesize copper complexes. It has been shown to activate autophagy by binding to the lysosomal membrane and activating the PI3K/Akt pathway. In addition, this molecule has been implicated in the structural analysis of tyrosinase, as well as growth factor activity. Ethyl 3-phenyl-1H-pyrazole-5-carboxylate also has a supramolecular structure. This compound exhibits inhibitory activity against cancer cells and cardiovascular diseases, as well as radiation. The functional theory on which this compound operates is not yet clear, but it may be due to its inhibitory activities on certain enzymes or proteins that are involved in cellular processes.

Peptide YY (3-36) (human) trifluoroacetate salt H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn -Arg -Tyr -Tyr -Ala -Ser -Leu -Arg Peptide YY (3.36) is a peptide hormone that is secreted by L cells in the small intestine and colon. It has been shown to be an effective treatment for obesity, type 2 diabetes, and other metabolic disorders. Peptide YY (3.36) has been shown to increase insulin sensitivity, reduce food intake and body weight, increase metabolic rate, and improve glucose homeostasis in animal studies. In humans, it has been found to have similar effects on postprandial plasma levels of peptide YY (3.

4,6-Dichloro-5-methylpyrimidine is an organic compound with a molecular formula of C6H4Cl2N2. It is the result of the reaction between pyrimidine and chloroform. 4,6-Dichloro-5-methylpyrimidine has been extracted from coal tar and can be found in two forms: as a dimer and as an isomer. The energy of 4,6-Dichloro-5-methylpyrimidine has been determined to be -3.3 kcal/mol by filtrating it through a filter paper. This chemical has also been shown to have an experimental constant of -1.8 liters at 25 degrees Celsius and 1 atmosphere pressure when in the gas phase. The crystal structure of 4,6-Dichloro-5-methylpyrimidine has been determined using microcalorimetry, which was then used to calculate the enthalpy change

Z-Asp-Glu-Val-Asp-chloromethylketone is a reactive compound that inhibits the activity of proteases and induces neuronal death. Z-Asp-Glu-Val-Asp-chloromethylketone has been shown to induce necrotic cell death in malignant brain cells and has neurotrophic properties. It also causes mitochondrial membrane depolarization, which leads to mitochondrial cytochrome c release and subsequent apoptosis. The reaction mechanism is still unclear but it may involve hydrogen bonding between the ketone group and the amide nitrogen atom of the aspartate residue.

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N-alpha-Acetyl-DL-arginine dihydrate (AAD) is a versatile building block that can be used to synthesize functionalized molecules. AAD is an intermediate for the production of pharmaceuticals and other useful compounds. It is also a reaction component in organic synthesis, and has been shown to have high purity.

N10-Methyl pteroic acid is a novel immunosuppressant that inhibits T-cell proliferation and promotes regression of inflammatory bowel disease. It has been shown to be effective in treating cancer patients, with the terminal half-life being approximately 20 hours. N10-Methyl pteroic acid is a potent inhibitor of human acute lymphoblastic leukemia cells. It can also be used as an immunosuppressant for organ transplantation, with desorption from gels using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) and bioanalytical methods such as high performance liquid chromatography (HPLC).

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Please enquire for more information about N-Boc-3-amino-2-isobutyl-propionic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about Fmoc-D-glutamic acid gamma-benzyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 5-(t-Boc-amino)-1-pentyl-p-toluenesulfonate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Labelled Lacosamide (L098500). Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant. References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007)

Starting materials for peptide synthesis, peptidomimetic and medicinal chemistry, protected amino acids, coupling reagents, linkers and resins, natural and unusual amino acids and building blocks used in peptide synthesis, peptidomimetic and medicinal chemistry. Reagents for PEGylation, Life science Research and biocatalysis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Please enquire for more information about 2-[4-(4-Methoxyphenyl)piperazin-1-yl]-5-nitrobenzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

H-Lys-Val-OH hydrochloride salt is a polymerase chain that has been synthesized from the amino acid lysine. It is an optical sensor that can be used to detect and quantify proteins. H-Lys-Val-OH hydrochloride salt binds to DNA in the cell nucleus and is sensitive to the concentration of adenosine triphosphate (ATP) in cells. This nucleotide plays an important role in cellular energy production. The binding constants for H-Lys-Val-OH hydrochloride salt are determined from the fluorescence emission spectrum, which changes with different concentrations of ATP. The method can be used to measure glomerular filtration rates and can be used as a low energy radiation source for cervical cancer treatment.

Please enquire for more information about 3-Phenyl-2H-1,4-benzothiazine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2,4-dimethoxy-1-(2-(1-methyl(2-pyridyl))vinyl)benzene, iodide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 7-Chloro-2-(2-chlorophenyl)-8-methylquinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 4-(2-Bromoethyl)-1-methyl-1H-pyrazole including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-(1H-Benzimidazol-2-yl)alanine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile TrpOH is a recombinant peptide that is a potent endothelin receptor antagonist. It binds to the endothelin receptor, blocking the binding of endothelin and preventing activation of the receptor. Acetyl-(Ala11·15)-Endothelin (6-21) Ac has been shown to inhibit atrial natriuretic peptide levels and reduce blood pressure in experimental models. This drug also prevents balloon injury by blocking the binding of endothelin to its receptors and inhibits growth factor β1, which is an important mediator in pulmonary hypertension. The mechanism of action for this drug is not fully understood, but it may work through inhibiting

Please enquire for more information about Methyl 3-amino-6-(5-methyl-2-thienyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine methyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

N-Methyl-DL-leucine hydrochloride is a peptide that has been shown to have antimicrobial properties. It also binds to the receptor site and blocks the binding of a virus, inhibiting viral life. N-Methyl-DL-leucine hydrochloride has been shown to inhibit the growth of bacteria by preventing bacterial esterase activity. This inhibition leads to the accumulation of esters, which are toxic to bacteria. N-Methyl-DL-leucine hydrochloride is an intramolecular hydrogen bonder and is prepared through hplc. It's a cyclic peptide with a hydroxyl group on its side chain at position 2, making it an alpha amino acid. Hydrolysis of this molecule occurs in acidic conditions with hydrochloric acid, yielding methyl D-leucine and hydrogen chloride gas.

3-Methyl-2-buten-1-yl thiolacetate is a precursor to 3-methyl-2-buten-1-thiol and ocimene. It is an acidic, laminar, terpene that has a diameter of 178.3 pm. 3-Methyl-2-buten-1-yl thiolacetate is found in many essential oils including valencene, β−caryophyllene, α−pinene, and β−pinene. The structural formula for this compound is CH3CSCH=CHSCH3. This compound also has surfactant properties and can be used as a prenyl or sulfide donor in protein synthesis reactions.

D-Cysteine is an important source of sulfide in human metabolism. It is the precursor for glutathione. It plays important role in protein structure and in metal binding. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

DL-Lysine monohydrochloride acts as an intermediate in the preparation of 3-amino-azepan-2-one. It also serves as an essential amino acid. It is used as animal feed. In addition to this, it is used in the construction of polylysine polymers, which finds application in lysine-based polypeptide gels and films. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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Applications O-2-Amino-2-methylpropyl Bilastine-d6 is an intermediate used in the synthesis of Bilastine-d6 (B385002), which is labelled Bilastine. It is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. References Van Cauwenberge, P., et al.: Clin. Exp. Allergy, 30, 891 (2000), Bauchau, V., et al.: Eur. Respir. J., 24, 758 (2004), Lehman, J., et al.: Drugs, 66, 2309 (2006),

H-Ile-Trp-OH is an acetylcholine esterase inhibitor that has been shown to have potent inhibitory activity against lorazepam. It binds to the active site of the enzyme, preventing it from breaking down acetylcholine and other neurotransmitters in the brain. H-Ile-Trp-OH is also a potent inhibitor of stenotrophomonas maltophilia, which is a bacterium found in chronic bronchitis patients. The drug has been tested in clinical studies for use as an immunomodulatory agent but has not yet been approved for this purpose.

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L-Leucine 4-nitrophenyl ester hydrochloride is a reaction component, reagent, and useful scaffold that is used in the synthesis of complex compounds. It is a versatile building block and useful intermediate that can be used to synthesize fine chemicals such as pharmaceuticals, agrochemicals, or dyes. L-Leucine 4-nitrophenyl ester hydrochloride has CAS number 75691-76-8.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Please enquire for more information about Fmoc-O-2-bromo-Z-L-tyrosine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 1-Bromo-3-methyl-2-butanol, can be used for preparation and polymerization of racemic isopropylthiirane. References Dumas, Ph., et al.: Sciences Chimiques, 277, 939 (1973);

Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes. References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);

2,2'-[5-(4H-1,2,4-Triazol-4-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile) is an inorganic compound. It is a white solid that is soluble in organic solvents such as acetonitrile and dimethylformamide. This compound has been used to synthesize methylbenzene derivatives and in the synthesis of carbon tetrachloride.

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