EGFR
Los inhibidores del receptor del factor de crecimiento epidérmico (EGFR) son compuestos que bloquean la señalización del EGFR, un receptor que a menudo está sobreexpresado en varios tipos de cáncer y que juega un papel crucial en la angiogénesis. Los inhibidores del EGFR se utilizan para prevenir el crecimiento tumoral y las metástasis al interrumpir las vías que promueven la formación de vasos sanguíneos en los tumores. Estos inhibidores son ampliamente utilizados en la investigación y terapia contra el cáncer. En CymitQuimica, ofrecemos una amplia selección de inhibidores de EGFR de alta calidad para apoyar su investigación en oncología y angiogénesis.
Productos de "EGFR"
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CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Fórmula:C18H13BrN4OPureza:96.68% - 98.09%Forma y color:SolidPeso molecular:381.23EGFR mutant-IN-1
EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.Fórmula:C34H39ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:632.17BMS-690514
CAS:BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Fórmula:C19H24N6O2Pureza:99.08%Forma y color:SolidPeso molecular:368.43Astragaloside VI
CAS:Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway.Fórmula:C47H78O19Pureza:98%Forma y color:SolidPeso molecular:947.122EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Forma y color:Lyophilized PowderPeso molecular:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-120 kDa based on Tris-Bis PAGE result.PD 158780
CAS:Fórmula:C14H12BrN5Pureza:>97.0%(HPLC)Forma y color:White to Yellow to Green powder to crystalPeso molecular:330.19WAY-270360
CAS:WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C22H19N3O3Pureza:98.66%Forma y color:SolidPeso molecular:373.4Protopine hydrochloride
CAS:Protopine inhibits thromboxane, lowers intracellular calcium, and reduces cell adhesion by altering adhesive factors.Fórmula:C20H20ClNO5Pureza:98%Forma y color:Prisms From Alc SolidPeso molecular:389.83MAPK-IN-2
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cellFórmula:C20H11Cl2N3OPureza:98%Forma y color:SolidPeso molecular:380.23JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Fórmula:C16H11BrFN3O2Pureza:99.50%Forma y color:SolidPeso molecular:376.18Ref: TM-T8431
2mg40,00€5mg74,00€10mg105,00€25mg178,00€50mg273,00€100mg391,00€200mg557,00€1mL*10mM (DMSO)84,00€Rilzabrutinib
CAS:Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).Fórmula:C36H40FN9O3Pureza:97.87% - 99.76%Forma y color:SolidPeso molecular:665.76Ref: TM-T12542
1mg99,00€5mg235,00€10mg376,00€25mg655,00€50mg944,00€100mg1.320,00€500mg2.642,00€1mL*10mM (DMSO)344,00€WZ-3146
CAS:WZ3146: EGFR(L858R/E746_A750) inhibitor, IC50=2 nM, selective, doesn't block ERBB2(T798I).Fórmula:C24H25ClN6O2Pureza:97.15%Forma y color:SolidPeso molecular:464.95Ref: TM-T6733
1mg52,00€2mg74,00€5mg97,00€10mg180,00€25mg319,00€50mg510,00€100mg730,00€1mL*10mM (DMSO)106,00€EGFR-IN-123
CAS:EGFR-IN-123 (compound D06) is an effective EGFR inhibitor. It exhibits inhibitory activity against several cell lines including PC-9G, A549, A431, and HCT116, with IC50 values of 0.74, 1.36, 1.20, and 2.53 μM respectively.Fórmula:C24H27F3N6OForma y color:SolidPeso molecular:472.51BGB-102
CAS:BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.Fórmula:C22H25BrN4O2Pureza:99.02%Forma y color:SolidPeso molecular:457.36Erlotinib Hydrochloride
CAS:Fórmula:C22H23N3O4·HClPureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:429.90WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C28H30F3N7O3Pureza:97.93% - 98.81%Forma y color:SolidPeso molecular:569.58DBPR112
CAS:DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.Fórmula:C32H31N5O3Pureza:98.29%Forma y color:SolidPeso molecular:533.62NSC 228155
CAS:NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.Fórmula:C11H6N4O4SPureza:99.84%Forma y color:SolidPeso molecular:290.25Ref: TM-T6908
2mg35,00€5mg50,00€10mg66,00€25mg125,00€50mg205,00€100mg369,00€200mg495,00€1mL*10mM (DMSO)52,00€SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Fórmula:C16H13NO2Pureza:99.45% - 99.55%Forma y color:SolidPeso molecular:251.28JBJ-07-149
CAS:JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].Fórmula:C28H26N6O2SForma y color:SolidPeso molecular:510.61
