BCL
Los inhibidores de BCL son compuestos que se dirigen a la familia de proteínas BCL-2, que juegan un papel clave en la regulación de la apoptosis. La familia BCL-2 incluye miembros proapoptóticos y antiapoptóticos que controlan la vía mitocondrial de la apoptosis. Inhibir las proteínas BCL-2 antiapoptóticas puede promover la muerte celular en células cancerosas, lo que convierte a los inhibidores de BCL en herramientas cruciales en la investigación de terapias contra el cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de BCL de alta calidad para apoyar su investigación en cáncer, apoptosis y biología celular.
Productos de "BCL"
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PROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Fórmula:C45H45BrN6O10SPureza:98%Forma y color:SolidPeso molecular:941.84S55746 hydrochloride
CAS:S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.Fórmula:C43H43ClN4O6Pureza:98%Forma y color:SolidPeso molecular:747.28Tanshinone IIB
CAS:TSB reduces DNA damage, cytotoxicity, and apoptosis in rat neurons, balances Bax, bcl-2, caspase-3 proteins, and has potential for treating stroke.Fórmula:C19H18O4Pureza:98%Forma y color:SolidPeso molecular:310.349Crenulatin
CAS:Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/LFórmula:C11H20O6Pureza:98%Forma y color:SolidPeso molecular:248.275Obovatol
CAS:Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's diseaseFórmula:C18H18O3Pureza:98%Forma y color:SolidPeso molecular:282.33Isolimonexic acid
CAS:Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.Fórmula:C26H30O10Pureza:98%Forma y color:SolidPeso molecular:502.51Ferruginol
CAS:Ferruginol exhibits anti-cancer, anti-inflammatory, cardioprotective properties and can trigger NSCLC cell apoptosis.Fórmula:C20H30OPureza:98%Forma y color:SolidPeso molecular:286.459Metaproterenol
CAS:Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).Fórmula:C11H17NO3Pureza:98%Forma y color:SolidPeso molecular:211.26Panaxynol
CAS:Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.Fórmula:C17H24OPureza:98%Forma y color:SolidPeso molecular:244.37Coronarin D
CAS:Coronarin D has antifungal properties, with 2 mg/mL MIC & 4 mg/mL MFC against C. albicans, inhibits NF-kappaB, and enhances antibiotic effects.Fórmula:C20H30O3Pureza:98%Forma y color:SolidPeso molecular:318.457Tapotoclax
CAS:Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.Fórmula:C33H41ClN2O5SPureza:98.8%Forma y color:SolidPeso molecular:613.21Liriodenine
CAS:Liriodenine: Topoisomerase II inhibitor, antitumor, antibacterial, antifungal, prevents arrhythmias, and may block M3 receptors.Fórmula:C17H9NO3Pureza:98%Forma y color:SolidPeso molecular:275.26WEHI-9625
CAS:WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).Fórmula:C34H27NO5S2Pureza:98%Forma y color:SolidPeso molecular:593.71(S)-Purvalanol B
CAS:(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .Fórmula:C20H25ClN6O3Pureza:98%Forma y color:SolidPeso molecular:432.9Altholactone
CAS:Altholactone, a potential antimicrobial for ciprofloxacin-resistant S. aureus/E. faecalis, also induces cancer cell apoptosis.Fórmula:C13H12O4Pureza:98%Forma y color:SolidPeso molecular:232.23WEHI-539 hydrochloride
CAS:WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Fórmula:C31H30ClN5O3S2Pureza:98%Forma y color:SolidPeso molecular:620.18Serratenediol
CAS:Serratenediol inhibits EBV-EA stronger than oleanolic acid, boosts osteoblast growth, and suppresses HL-60 cells by modulating Bax/Bcl-xL.Fórmula:C30H50O2Pureza:98%Forma y color:SolidPeso molecular:442.72Myricanone
CAS:Myricanone exhibits antioxidant, anticancer, apoptosis-inducing, and anti-androgenic properties with enzyme inhibition.Fórmula:C21H24O5Pureza:98%Forma y color:SolidPeso molecular:356.41Pyridoclax
CAS:Pyridoclax is an inhibitor of potential Mcl-1.Fórmula:C29H22N4Pureza:98%Forma y color:SolidPeso molecular:426.51Mcl1-IN-11
CAS:Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.Fórmula:C38H41N3O5S2Pureza:98%Forma y color:SolidPeso molecular:683.88
