Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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Plogosertib
CAS:Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Fórmula:C34H48N8O3Pureza:99.15% - 99.85%Forma y color:SolidPeso molecular:616.797P18IN003
CAS:P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFórmula:C17H16N2O3Pureza:98.77%Forma y color:SolidPeso molecular:296.32AM5992
CAS:AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Fórmula:C27H33FN8OPureza:98%Forma y color:SoildPeso molecular:504.6Synstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFórmula:C133H207N35O46Pureza:98%Forma y color:SolidPeso molecular:3032.27GLPG0187
CAS:GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Fórmula:C29H37N7O5SPureza:100% - 99.70%Forma y color:SolidPeso molecular:595.71P18IN011
CAS:P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).Fórmula:C15H12N2O5SPureza:97.63%Forma y color:SolidPeso molecular:332.33Ref: TM-T8576
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)178,00€Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Fórmula:C11H13N3O5Pureza:98%Forma y color:SolidPeso molecular:267.24TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Fórmula:C17H14BrFN6O3SForma y color:SolidPeso molecular:481.3UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Fórmula:C17H17N3SPureza:99.81%Forma y color:SolidPeso molecular:295.4PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent inhibitor of PD-1/PD-L1, displaying pronounced anticancer activity with an IC50 value of 2.4 nM.Pureza:98%Forma y color:Odour SolidTMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Fórmula:C72H66N8O12S4Pureza:99.11% - 99.85%Forma y color:SolidPeso molecular:1363.6GSK4418959
CAS:GSK4418959 (IDE275) is an oral, non-covalent, reversible, and selective WRN helicase inhibitor.inhibits ATPase and DNA unwinding functions. MSI-H.Fórmula:C31H30F4N4O5SForma y color:SoildPeso molecular:646.65AVG-233
CAS:AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Fórmula:C26H22ClN5O3Pureza:99%Forma y color:SolidPeso molecular:487.94GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Fórmula:C21H15N5O3S2Pureza:99.32%Forma y color:SolidPeso molecular:449.51Ref: TM-T24125
1mg52,00€5mg97,00€10mg169,00€25mg329,00€50mg537,00€100mg868,00€200mg1.169,00€1mL*10mM (DMSO)111,00€IMMH 010 maleate
CAS:IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Fórmula:C36H36BrClN2O9Forma y color:SoildPeso molecular:756.04NCGC00029283
CAS:NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μMFórmula:C18H12FN3O3Pureza:99.6%Forma y color:SolidPeso molecular:337.3Ref: TM-T40823
1mg111,00€2mg163,00€5mg264,00€10mg432,00€25mg747,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)283,00€Docosanoic acid
CAS:Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.Fórmula:C22H44O2Pureza:100%Forma y color:Waxy Solid Liquid Othersolid PelletslargecrystalsPeso molecular:340.58N6-Methyladenine
CAS:N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.Fórmula:C6H7N5Pureza:98.35%Forma y color:SolidPeso molecular:149.15Vaccarin
CAS:Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Fórmula:C32H38O19Pureza:99.16% - 99.97%Forma y color:SolidPeso molecular:726.63Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Fórmula:C16H15NO3Pureza:99.59%Forma y color:SolidPeso molecular:269.3Ref: TM-T25969
1mg333,00€5mg922,00€10mg1.140,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.664,00€
