Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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Ac-rC Phosphoramidite
CAS:Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.Fórmula:C47H64N5O9PSiPureza:99.49%Forma y color:SolidPeso molecular:902.1Pyridostatin
CAS:Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome orFórmula:C31H32N8O5Pureza:98%Forma y color:SolidPeso molecular:596.64SB273005
CAS:SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Fórmula:C22H24F3N3O4Pureza:99.58%Forma y color:SolidPeso molecular:451.44Ribociclib hydrochloride
CAS:Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C23H31ClN8OPureza:98%Forma y color:SolidPeso molecular:471PD-1/PD-L1-IN-33
CAS:PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Fórmula:C26H27N5OPureza:98%Forma y color:SolidPeso molecular:425.53KIF18A-IN-14
CAS:KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.Fórmula:C26H32F3N5O6SForma y color:SolidPeso molecular:599.62MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Fórmula:C22H21ClFN3O3SPureza:100%Forma y color:SolidPeso molecular:461.94Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Pureza:> 95%Forma y color:LiquidPeso molecular:145.36 kDa8-Azahypoxanthine
CAS:8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Fórmula:C4H3N5OPureza:≥98%Forma y color:Light Yellow To Light Beige Fine CrystallinePeso molecular:137.1Ref: TM-T20102
5mg48,00€10mg66,00€25mg104,00€50mg154,00€100mg216,00€200mg324,00€1mL*10mM (DMSO)48,00€Datelliptium chloride hydrochloride
CAS:Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.Fórmula:C23H29Cl2N3OPureza:99.46%Forma y color:SolidPeso molecular:434.4ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Fórmula:C29H31N5O4Pureza:98.53% - 99.11%Forma y color:Pale Yellow SolidPeso molecular:513.59MBM-17
CAS:MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM).Fórmula:C28H28N6O2Pureza:98%Forma y color:SolidPeso molecular:480.56Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.Fórmula:C25H30N6O2Pureza:98.32%Forma y color:SolidPeso molecular:446.54BVDV-IN-1
CAS:BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.Fórmula:C20H22N4OPureza:98.43%Forma y color:SolidPeso molecular:334.41Ref: TM-T9103
1mg40,00€5mg90,00€10mg131,00€25mg255,00€50mg375,00€100mg535,00€200mg725,00€1mL*10mM (DMSO)90,00€KSI-3716
CAS:KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.Fórmula:C17H11BrCl2N2O2Pureza:98.94%Forma y color:SolidPeso molecular:426.09IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Fórmula:C23H21Cl2NO5Pureza:98%Forma y color:SolidPeso molecular:462.32Rabacfosadine
CAS:Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.Fórmula:C21H35N8O6PPureza:98.75% - 99.43%Forma y color:SolidPeso molecular:526.53CHK1-IN-2
CAS:CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Fórmula:C20H22N4OSPureza:98%Forma y color:SolidPeso molecular:366.48THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Forma y color:SolidPeso molecular:558.07Ref: TM-T4293
1mg63,00€2mg90,00€5mg111,00€10mg153,00€25mg329,00€50mg472,00€100mg687,00€500mg1.415,00€1mL*10mM (DMSO)137,00€IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Fórmula:C23H22N2O5Pureza:98%Forma y color:SolidPeso molecular:406.43
