Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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PD 407824
CAS:PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).Fórmula:C20H12N2O3Pureza:98.02%Forma y color:SolidPeso molecular:328.32AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Fórmula:C28H21N7OSPureza:98.35% - 98.9%Forma y color:SolidPeso molecular:503.58Ref: TM-T6380
1mg52,00€5mg97,00€10mg166,00€25mg303,00€50mg467,00€100mg682,00€500mg1.415,00€1mL*10mM (DMSO)105,00€GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Fórmula:C27H28F3N5O2SPureza:98.85% - 99.5%Forma y color:SolidPeso molecular:543.6Ref: TM-T6282
1mg37,00€2mg52,00€5mg74,00€10mg124,00€25mg207,00€50mg374,00€100mg557,00€200mg797,00€500mg1.216,00€β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Fórmula:C15H12ClN3O2SForma y color:SolidPeso molecular:333.79Socazolimab
CAS:Socazolimab (ZKAB001) is a monoclonal antibody targeting PD-L1 with antitumor activity, used in studies of recurrent or metastatic cervical cancer.Pureza:95%Forma y color:LiquidPS423
CAS:PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.Fórmula:C25H23F3O9Pureza:98.81% - 99.26%Forma y color:SolidPeso molecular:524.442'-Deoxy-2'-fluoroarabinoadenosine
CAS:2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue with extensive anti-tumor activity and can be used for the study of tumor diseases.Fórmula:C10H12FN5O3Pureza:99.44%Forma y color:SolidPeso molecular:269.23PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Fórmula:C22H25ClN2O4Forma y color:SolidPeso molecular:416.90Trilaciclib hydrochloride
CAS:Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Fórmula:C24H32Cl2N8OPureza:98.61% - 99.69%Forma y color:SolidPeso molecular:519.47Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Fórmula:C21H31N7OPureza:99.75%Forma y color:SolidPeso molecular:397.52Ref: TM-TQ0053
1mg48,00€5mg101,00€10mg178,00€25mg304,00€50mg437,00€100mg615,00€200mg830,00€1mL*10mM (DMSO)111,00€KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Fórmula:C28H38N4O5S2Pureza:98.45%Forma y color:SolidPeso molecular:574.76Ro5-3335
CAS:Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins.Fórmula:C13H10ClN3OPureza:99.42% - 99.50%Forma y color:SolidPeso molecular:259.69(S)-PF-06873600
CAS:(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK.Fórmula:C20H27F2N5O4SPureza:98.55%Forma y color:SolidPeso molecular:471.52Orotic acid zinc
CAS:Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.Fórmula:C10H6N4O8ZnPureza:99.13%Forma y color:SolidPeso molecular:188.79VVD-214
CAS:VVD-214 (RO7589831) is a WRN deconjugation enzyme lethal-mutagenic inhibitor that can be used to study proliferative diseases.Fórmula:C20H21F2N3O4SPureza:99.24%Forma y color:SoildPeso molecular:437.46N-Nitrosonornicotine
CAS:N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.Fórmula:C9H11N3OForma y color:SolidPeso molecular:177.2ARQ 621
CAS:ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Fórmula:C28H24Cl2FN5O2Pureza:98.38%Forma y color:SolidPeso molecular:552.43Lifitegrast
CAS:Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Fórmula:C29H24Cl2N2O7SPureza:99.39% - 99.66%Forma y color:SolidPeso molecular:615.48Cdc7-IN-7c
CAS:Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.Fórmula:C15H17N5OSPureza:99.31% - 99.77%Forma y color:SolidPeso molecular:315.39Ref: TM-T23867
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)633,00€CDK12-IN-2
CAS:CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.Fórmula:C32H32N6O2Pureza:99.54%Forma y color:SolidPeso molecular:532.64Ref: TM-T39752
1mg92,00€5mg216,00€10mg376,00€25mg620,00€50mg889,00€100mg1.198,00€1mL*10mM (DMSO)255,00€
