Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Productos de "Cromatina / Epigenética"
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GSK126
CAS:GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Fórmula:C31H38N6O2Pureza:98% - 99.67%Forma y color:SolidPeso molecular:526.67Ref: TM-T2079
2mg44,00€5mg65,00€10mg88,00€25mg152,00€50mg227,00€100mg349,00€200mg455,00€1mL*10mM (DMSO)74,00€SMYD2-IN-1
CAS:SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Fórmula:C25H25Cl2F2N7O2Pureza:98%Forma y color:SolidPeso molecular:564.41AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Forma y color:SolidPeso molecular:381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.88%Forma y color:SolidPeso molecular:456.37IHMT-EZH2-426
IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5Fórmula:C31H35FN4O4SPureza:98%Forma y color:SolidPeso molecular:578.7MS9715
MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligaseFórmula:C58H74FN9O5SPureza:98%Forma y color:SolidPeso molecular:1028.33GSK467
CAS:GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).Fórmula:C17H13N5O2Pureza:99.55%Forma y color:SolidPeso molecular:319.32Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Fórmula:C28H32N4O3Pureza:99.25% - 99.49%Forma y color:SolidPeso molecular:472.58GSK778 hydrochloride
CAS:GSK778 hydrochloride is a selective BET BD1 bromodomain inhibitor, with IC50s ranging from 41 to 143 nM, effective in cancer models.Fórmula:C30H34ClN5O3Pureza:97.45%Forma y color:SolidPeso molecular:548.08Ref: TM-T9703L
1mg115,00€5mg249,00€10mg368,00€25mg562,00€50mg787,00€100mg1.054,00€1mL*10mM (DMSO)319,00€PBRM1-BD2-IN-7
CAS:PBRM1-BD2-IN-7, a PBRM1 bromodomain inhibitor with an IC50 of 0.29 μM, is used in cancer research.Fórmula:C16H15ClN2OPureza:99% - 99.86%Forma y color:SoildPeso molecular:286.76Ref: TM-T60155
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)240,00€Upadacitinib
CAS:Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.Fórmula:C17H19F3N6OPureza:98.96% - 99.93%Forma y color:SolidPeso molecular:380.37Ref: TM-T7503
1mg47,00€2mg62,00€5mg89,00€10mg130,00€25mg220,00€50mg306,00€100mg434,00€200mg662,00€500mg1.169,00€1mL*10mM (DMSO)48,00€BRD7-IN-1
CAS:BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.Fórmula:C22H28Cl2N4O3Pureza:98.95%Forma y color:SolidPeso molecular:467.39OXF BD 02
CAS:OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.Fórmula:C18H17NO3Pureza:98.25%Forma y color:SolidPeso molecular:295.33LSD1-IN-24
CAS:LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing responseFórmula:C18H20N2OSPureza:99.53%Forma y color:SoildPeso molecular:312.43Ref: TM-T67871
1mg57,00€5mg120,00€10mg187,00€25mg374,00€50mg612,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)133,00€BRD0639
CAS:BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Fórmula:C21H22ClN5O4SPureza:99.85%Forma y color:SolidPeso molecular:475.95EEDi-5285
CAS:EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Fórmula:C24H22FN5O3SPureza:100%Forma y color:SolidPeso molecular:479.53(+)-JQ1 PA
CAS:(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).Fórmula:C22H20ClN5OSPureza:98.36%Forma y color:SolidPeso molecular:437.95Desidustat
CAS:Desidustat is an inhibitor of HIF hydroxylase.Fórmula:C16H16N2O6Pureza:98%Forma y color:SolidPeso molecular:332.31Ref: TM-T5176
1mg35,00€2mg52,00€5mg94,00€10mg167,00€25mg300,00€50mg516,00€100mg732,00€1ml*10 (DMSO)112,00€Histone Acetyltransferase Inhibitor II
CAS:Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activityFórmula:C20H16Br2O3Pureza:97.13%Forma y color:SolidPeso molecular:464.15(R)-(-)-JQ1 Enantiomer
CAS:(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)Fórmula:C23H25ClN4O2SPureza:99.38%Forma y color:SolidPeso molecular:456.99
