NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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Physalin O
CAS:Physalin O has anti-inflammatory properties, binds with GSH, and inhibits NO production.Fórmula:C28H32O10Pureza:98%Forma y color:SolidPeso molecular:528.554JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Fórmula:C17H13NaO4Pureza:95.08%Forma y color:SolidPeso molecular:304.27Parthenolide
CAS:Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB and HDAC1 inhibitor with anti-inflammatory effect. Cost-effective and quality-assured.Fórmula:C15H20O3Pureza:99.10% - 99.46%Forma y color:White To Pale Yellow Crystalline PowderPeso molecular:248.32GSK547
CAS:GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.Fórmula:C20H18F2N6OPureza:99.17%Forma y color:SolidPeso molecular:396.39Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Forma y color:Odour SolidHS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Fórmula:C17H16N4O3Pureza:97.34%Forma y color:SolidPeso molecular:324.33RIP1 kinase inhibitor 4
CAS:RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].Fórmula:C23H23N5Pureza:98%Forma y color:SolidPeso molecular:369.46CHPG sodium salt
CAS:CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways.Fórmula:C8H7ClNNaO3Pureza:100%Forma y color:SolidPeso molecular:223.59IRAK4-IN-8
CAS:IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.Fórmula:C23H23F2N7O2SPureza:99.39%Forma y color:SolidPeso molecular:499.54Ref: TM-T63388
1mg825,00€2mg1.130,00€5mg1.681,00€10mg2.270,00€25mg3.372,00€50mg4.541,00€100mg6.146,00€Rhynchophylline
CAS:Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.Fórmula:C22H28N2O4Pureza:99.44%Forma y color:Red Brown Or White Fine PowderPeso molecular:384.47Indole-3-carbinol
CAS:Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFórmula:C9H9NOPureza:100% - 97.06%Forma y color:SolidPeso molecular:147.17Coronalolic acid
CAS:Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.Fórmula:C30H46O4Pureza:98%Forma y color:SolidPeso molecular:470.681-Isomangostin
CAS:1-Isomangostin has cytotoxic and anticomplementary activities.Fórmula:C24H26O6Pureza:99.71%Forma y color:SolidPeso molecular:410.462,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Fórmula:C8H8O3Pureza:99.75%Forma y color:Yellow PowderPeso molecular:152.15NF-κB-IN-12
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].Fórmula:C30H26N6O5SPureza:98%Forma y color:SolidPeso molecular:582.63Zimlovisertib
CAS:Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).Fórmula:C18H20FN3O4Pureza:98.21%Forma y color:SolidPeso molecular:361.37Ref: TM-TQ0167
1mg35,00€5mg67,00€10mg115,00€25mg224,00€50mg404,00€100mg655,00€200mg910,00€1mL*10mM (DMSO)73,00€IRAK4-IN-25
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatoryFórmula:C23H25N5O4Pureza:98%Forma y color:SolidPeso molecular:435.48JC124
CAS:JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.Fórmula:C17H19ClN2O4SPureza:98.54%Forma y color:SolidPeso molecular:382.86Ref: TM-T25548
1mg64,00€5mg145,00€10mg226,00€25mg379,00€50mg538,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)160,00€RIPK3-IN-4
CAS:RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage.Fórmula:C24H18BrFN4O3SPureza:98%Forma y color:SolidPeso molecular:541.39
