CXCR
Los CXCR son una subfamilia de GPCR que se unen a quimiocinas, pequeñas proteínas de señalización que guían el movimiento de las células inmunitarias hacia los sitios de inflamación, infección o lesión. Los CXCR desempeñan roles cruciales en las respuestas inmunitarias, la metástasis del cáncer y las enfermedades inflamatorias. Los moduladores de CXCR se están investigando por su potencial en el tratamiento de enfermedades autoinmunes, cáncer y afecciones inflamatorias crónicas. En CymitQuimica, ofrecemos una gama de moduladores de CXCR de alta calidad para apoyar su investigación en inmunología, oncología e inflamación.
Productos de "CXCR"
Ordenar por
IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Fórmula:C21H36Cl2N4S2Pureza:98.03%Forma y color:SolidPeso molecular:479.57Ref: TM-T11693L
1mg42,00€5mg89,00€10mg144,00€25mg283,00€50mg510,00€100mg740,00€500mg1.510,00€1mL*10mM (DMSO)88,00€SB-265610
CAS:SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Fórmula:C14H9BrN6OPureza:97.67%Forma y color:SolidPeso molecular:357.16Ref: TM-T16850
1mg56,00€5mg119,00€10mg187,00€25mg376,00€50mg560,00€100mg800,00€500mg1.644,00€1mL*10mM (DMSO)131,00€SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Fórmula:C23H27N3O5Pureza:98.03%Forma y color:SolidPeso molecular:425.48NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Fórmula:C23H33N5OPureza:98.18%Forma y color:SolidPeso molecular:395.54Ref: TM-T12269
1mg115,00€5mg274,00€10mg432,00€25mg772,00€50mg1.074,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)283,00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Fórmula:C33H39ClN2O2Pureza:99.21%Forma y color:SolidPeso molecular:531.13SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Fórmula:C21H27N5O5SForma y color:SolidPeso molecular:461.535ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Fórmula:C27H28F2N6O3Pureza:98.31%Forma y color:SolidPeso molecular:522.55Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Fórmula:C39H57N13O8S2·xC2HF3O2Peso molecular:900.08 (free base)AMG 487
CAS:AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Fórmula:C32H28F3N5O4Pureza:99.89%Forma y color:SolidPeso molecular:603.59Ref: TM-T10297L
1mg52,00€5mg115,00€10mg164,00€25mg263,00€50mg369,00€100mg587,00€200mg835,00€1mL*10mM (DMSO)154,00€Reparixin
CAS:Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Fórmula:C14H21NO3SPureza:98% - 99.89%Forma y color:SolidPeso molecular:283.39Ref: TM-T4163
1mg52,00€2mg79,00€5mg119,00€10mg187,00€25mg393,00€50mg587,00€100mg835,00€500mg1.663,00€1mL*10mM (DMSO)111,00€MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Fórmula:C16H16N6Pureza:97.02% - 98.78%Forma y color:SolidPeso molecular:292.34Ref: TM-T3992
1mg35,00€5mg64,00€10mg97,00€25mg188,00€50mg311,00€100mg487,00€200mg682,00€1mL*10mM (DMSO)67,00€Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Fórmula:C28H54N8Pureza:100% - 99.81%Forma y color:SolidPeso molecular:502.78LIT927
CAS:LIT927 (LIT-927) is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).Fórmula:C17H13ClN2O3Pureza:99.57% - 99.73%Forma y color:SolidPeso molecular:328.75MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Fórmula:C16H24N2O4Pureza:98.43%Forma y color:SolidPeso molecular:308.37CXCR7 antagonist-1
CAS:CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7.Fórmula:C21H19FN6OPureza:99.51%Forma y color:SolidPeso molecular:390.41CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Fórmula:C19H20Cl2FN3O4SPureza:99.53%Forma y color:SolidPeso molecular:476.35E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Fórmula:C28H37ClF3N3O3Forma y color:SolidPeso molecular:556.06VUF11207 fumarate
CAS:VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Fórmula:C31H39FN2O8Pureza:97.98%Forma y color:SolidPeso molecular:586.65Ref: TM-T13324
1mg43,00€2mg55,00€5mg88,00€10mg137,00€25mg273,00€50mg472,00€100mg680,00€200mg947,00€1mL*10mM (DMSO)97,00€CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Fórmula:C18H18N4O4Forma y color:SolidPeso molecular:354.36SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Fórmula:C18H23F2N5O4S2Pureza:98%Forma y color:SolidPeso molecular:475.53
