TLR
Los receptores tipo Toll (TLR) son una clase de proteínas que desempeñan un papel crítico en el sistema inmunitario innato al reconocer patrones moleculares asociados a patógenos (PAMP) e iniciar respuestas inmunitarias. Los TLR están involucrados en la detección de una amplia gama de patógenos, incluidos bacterias, virus y hongos, y son esenciales para la activación de las vías de señalización inflamatorias. La desregulación de la señalización de los TLR se asocia con enfermedades inflamatorias crónicas, trastornos autoinmunes y cáncer. En CymitQuimica, ofrecemos una variedad de moduladores de TLR de alta calidad para apoyar su investigación en inmunidad innata, inflamación y enfermedades infecciosas.
Productos de "TLR"
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CU-CPT-9a
CAS:CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Fórmula:C17H15NO2Pureza:99.01%Forma y color:SolidPeso molecular:265.31Ref: TM-T7317
1mg40,00€2mg52,00€5mg88,00€10mg126,00€25mg236,00€50mg432,00€100mg638,00€1mL*10mM (DMSO)87,00€Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Fórmula:C36H59N5O2Pureza:98.61%Forma y color:SolidPeso molecular:593.89Ref: TM-T17032
1mg172,00€2mg235,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)462,00€Procyanidin B1
CAS:Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Fórmula:C30H26O12Pureza:98.00% - 99.13%Forma y color:Red-Brown PowderPeso molecular:578.52Ref: TM-TQ0205
1mg51,00€5mg170,00€10mg274,00€25mg465,00€50mg652,00€100mg920,00€1mL*10mM (DMSO)221,00€TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.Fórmula:C17H23N5OPureza:99.93%Forma y color:SolidPeso molecular:313.4Ref: TM-T13167
1mg64,00€5mg140,00€10mg226,00€25mg368,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)156,00€Afimetoran
CAS:Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.Fórmula:C26H32N6OPureza:99.89%Forma y color:SolidPeso molecular:444.57Ref: TM-T39654
1mg92,00€5mg187,00€10mg311,00€25mg530,00€50mg748,00€100mg1.064,00€1mL*10mM (DMSO)215,00€Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Fórmula:C16H15F3N4Pureza:97.08% - 99.38%Forma y color:SolidPeso molecular:320.31CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Fórmula:C14H12N4OPureza:99.00%Forma y color:SolidPeso molecular:252.27Ref: TM-T7347
1mg48,00€5mg88,00€10mg127,00€25mg224,00€50mg349,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)106,00€AZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Fórmula:C29H43N7O5Forma y color:SolidPeso molecular:569.7CU-115
CAS:CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.Fórmula:C21H11F7INO2Pureza:100%Forma y color:SolidPeso molecular:569.21ABR-238901
CAS:ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFórmula:C11H9BrClN3O4SPureza:99.15%Forma y color:SolidPeso molecular:394.63Ref: TM-T39115
1mg123,00€5mg298,00€10mg472,00€25mg748,00€50mg1.026,00€100mg1.406,00€1mL*10mM (DMSO)328,00€SM-276001
CAS:SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.Fórmula:C16H21N7OPureza:99.37%Forma y color:SolidPeso molecular:327.38Ref: TM-T12933
1mg64,00€5mg139,00€10mg202,00€25mg364,00€50mg547,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)153,00€TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Fórmula:C22H25N5Pureza:99.4%Forma y color:SolidPeso molecular:359.47CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Fórmula:C17H13F3N4O2Pureza:99.84%Forma y color:SolidPeso molecular:362.31Ref: TM-T15017
1mg106,00€2mg150,00€5mg216,00€10mg283,00€25mg356,00€50mg432,00€100mg625,00€500mg1.293,00€1mL*10mM (DMSO)188,00€TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Fórmula:C21H25N5OPureza:98%Forma y color:SolidPeso molecular:363.46DSR-6434
CAS:DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Fórmula:C19H28N8O2Pureza:99.12%Forma y color:SolidPeso molecular:400.48TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Fórmula:C23H31N7Pureza:98%Forma y color:SoildPeso molecular:405.54Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Fórmula:C15H13F5N2O2Pureza:98%Forma y color:SolidPeso molecular:348.27Semapimod tetrahydrochloride
CAS:Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor.Fórmula:C34H56Cl4N18O2Pureza:99.8%Forma y color:SolidPeso molecular:890.74M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Fórmula:C13H13Cl2N3OSPureza:96.85%Forma y color:SolidPeso molecular:330.23AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Fórmula:C23H31N3O3Pureza:99.88%Forma y color:SolidPeso molecular:397.51Ref: TM-T61882
1mg103,00€5mg246,00€10mg395,00€25mg785,00€50mg1.130,00€100mg1.768,00€200mg2.357,00€1mL*10mM (DMSO)271,00€
