Pim
Las quinasas Pim son una familia de quinasas serina/treonina que juegan un papel clave en la supervivencia celular, la proliferación y la apoptosis. Estas quinasas son efectores aguas abajo en la vía de señalización JAK/STAT y están involucradas en varios procesos fisiológicos, incluidas las respuestas inmunitarias y la hematopoyesis. La sobreexpresión de las quinasas Pim se ha asociado con el desarrollo de cáncer, lo que las convierte en objetivos importantes para la intervención terapéutica. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de quinasas Pim de alta calidad para apoyar su investigación en oncología, biología celular y transducción de señales.
Productos de "Pim"
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Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Fórmula:C16H12O6Pureza:97.54% - 98.53%Forma y color:SolidPeso molecular:300.26Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Fórmula:C20H13N5OPureza:97.84% - 98.69%Forma y color:SolidPeso molecular:339.35Ref: TM-T5093
1mg89,00€2mg131,00€5mg183,00€10mg278,00€25mg490,00€50mg710,00€100mg998,00€1mL*10mM (DMSO)202,00€CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Fórmula:C26H24ClN3O3Pureza:95.88%Forma y color:SolidPeso molecular:461.94Ref: TM-T1834
1mg37,00€5mg80,00€10mg106,00€25mg208,00€50mg311,00€100mg472,00€200mg658,00€1mL*10mM (DMSO)81,00€Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Fórmula:C15H10O8Pureza:99.65% - 99.76%Forma y color:SolidPeso molecular:318.24Ref: TM-T8114
1mg88,00€5mg202,00€10mg303,00€25mg510,00€50mg733,00€100mg998,00€500mg1.985,00€1mL*10mM (DMSO)213,00€(2R)-Octyl-α-hydroxyglutarate
CAS:(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.Fórmula:C13H24O5Forma y color:SolidPeso molecular:260.33(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Fórmula:C11H6F3NO2SPureza:97.66% - 99.44%Forma y color:SolidPeso molecular:273.23K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Fórmula:C18H18N4OPureza:97.88%Forma y color:SolidPeso molecular:306.36Ref: TM-T27704
1mg185,00€2mg279,00€5mg426,00€10mg627,00€25mg938,00€50mg1.320,00€100mg1.786,00€500mg3.591,00€1mL*10mM (DMSO)415,00€VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Fórmula:C27H27N3O3Peso molecular:441.522Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.85%Forma y color:SolidPeso molecular:611.51FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Fórmula:C21H20F2N4O2SPureza:98%Forma y color:SolidPeso molecular:430.47
