p38 MAPK
Las p38 MAPK son un subgrupo de MAPK que responden a señales de estrés y están involucradas en la regulación de la inflamación, la diferenciación celular, la apoptosis y la autofagia. La señalización de p38 MAPK es crucial en las respuestas inmunitarias y está implicada en varias enfermedades, incluidas las condiciones inflamatorias crónicas, el cáncer y los trastornos neurodegenerativos. En CymitQuimica, ofrecemos una gama completa de inhibidores y moduladores de p38 MAPK para apoyar su investigación en inflamación, respuesta al estrés y desarrollo terapéutico.
Productos de "p38 MAPK"
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SD-169
CAS:SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.Fórmula:C9H8N2OPureza:98.60%Forma y color:SolidPeso molecular:160.17N-Feruloyloctopamine
CAS:N-Feruloyloctopamine is a natural product.Fórmula:C18H19NO5Pureza:99.67%Forma y color:SolidPeso molecular:329.35Ref: TM-TN1968
1mg89,00€5mg207,00€10mg304,00€25mg512,00€50mg740,00€100mg1.035,00€1mL*10mM (DMSO)172,00€Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Fórmula:C18H17N3O4SPureza:98.93%Forma y color:SolidPeso molecular:371.41Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Fórmula:C19H18FN3O4Pureza:100%Forma y color:SolidPeso molecular:371.36PD 169316
CAS:PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Fórmula:C20H13FN4O2Pureza:98.65%Forma y color:SolidPeso molecular:360.34RWJ-67657
CAS:RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.Fórmula:C27H24FN3OPureza:99.66%Forma y color:SolidPeso molecular:425.5Ref: TM-T16812
2mg47,00€5mg70,00€10mg96,00€25mg216,00€50mg349,00€100mg563,00€500mg1.188,00€1mL*10mM (DMSO)77,00€PLK1/p38γ-IN-1
CAS:PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFórmula:C21H26ClN3O2Pureza:98%Forma y color:SolidPeso molecular:387.9ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.52%Forma y color:SolidPeso molecular:405.41Ref: TM-T9697
1mg90,00€5mg215,00€10mg321,00€25mg582,00€50mg873,00€100mg1.216,00€1mL*10mM (DMSO)236,00€Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Fórmula:C26H30O13Pureza:98.84% - 99.27%Forma y color:SolidPeso molecular:550.51SB-203580
CAS:Producto controladoStability -200C Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase. References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),Fórmula:C21H16FN3OSForma y color:NeatPeso molecular:377.4310-Methoxy-canthin-6-one
CAS:10-Methoxy-canthin-6-one (Mtx-C) acts as a DNA damage inducer that embeds into DNA, promoting cell cycle arrest at the G2/M phase. This process triggers myeloid differentiation in acute myeloid leukemia cells (AML) and leukemia stem cells (LSC). Differentiation in AML and LSC cells is characterized by increased expression of myeloperoxidase, CD15, CD11b, and CD14, along with the activation of p38 MAPK. 10-Methoxy-canthin-6-one is utilized in the study of leukemia.Fórmula:C15H10N2O2Forma y color:SolidPeso molecular:250.25Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Fórmula:C8H12ClNO3Pureza:96.17% - 99.85%Forma y color:Physical Description Beige Solid (Ntp 1992)Peso molecular:205.64p38-α MAPK-IN-1
CAS:p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.Fórmula:C27H35N5O3Pureza:99.52%Forma y color:SolidPeso molecular:477.6Ref: TM-T12347
1mg88,00€5mg180,00€10mg281,00€25mg520,00€50mg777,00€100mg1.169,00€200mg1.568,00€1mL*10mM (DMSO)188,00€SB 203580 Hydrochloride
CAS:Producto controladoFórmula:C21H16FN3OS·HClForma y color:NeatPeso molecular:377.43 + 36.46AS-252424
CAS:Producto controladoApplications AS-252424 is a novel, potent, and selective phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is also an inhibitor of Casein kinase and PI3K p110α. References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Edling, C.E., et al.: Clin. Cancer Res., 16, 4928 (2010); Condliffe, A.M., et al.: Blood, 106, 1432 (2005)Fórmula:C14H8FNO4SForma y color:NeatPeso molecular:305.28LY 294002 Hydrochloride
CAS:Producto controladoApplications LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);Fórmula:C19H17NO3·(HCl)Forma y color:NeatPeso molecular:343.8
