p38 MAPK
Las p38 MAPK son un subgrupo de MAPK que responden a señales de estrés y están involucradas en la regulación de la inflamación, la diferenciación celular, la apoptosis y la autofagia. La señalización de p38 MAPK es crucial en las respuestas inmunitarias y está implicada en varias enfermedades, incluidas las condiciones inflamatorias crónicas, el cáncer y los trastornos neurodegenerativos. En CymitQuimica, ofrecemos una gama completa de inhibidores y moduladores de p38 MAPK para apoyar su investigación en inflamación, respuesta al estrés y desarrollo terapéutico.
Productos de "p38 MAPK"
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p38 MAPK Inhibitor
CAS:p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.Fórmula:C20H13ClFN3OPureza:99.24%Forma y color:SolidPeso molecular:365.79Ref: TM-T36010
1mg96,00€5mg294,00€10mg459,00€25mg677,00€50mg929,00€100mg1.235,00€200mg1.681,00€500µg59,00€WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:98.98%Forma y color:SolidPeso molecular:528.61EO-1606
CAS:EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.Fórmula:C21H17ClFNOPureza:98.84% - 99.27%Forma y color:SolidPeso molecular:353.82R1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Fórmula:C19H19ClF2N4O3Pureza:99.42%Forma y color:SolidPeso molecular:424.83TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Fórmula:C20H12F3N3Pureza:98.77% - 99.94%Forma y color:SolidPeso molecular:351.32Ref: TM-T4645
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg235,00€100mg329,00€200mg464,00€1mL*10mM (DMSO)71,00€TAK-715
CAS:TAK-715 is a p38 MAPK inhibitor for p38α.Fórmula:C24H21N3OSPureza:99.69%Forma y color:SolidPeso molecular:399.51Ref: TM-T6150
1mg40,00€2mg52,00€5mg87,00€10mg99,00€25mg170,00€50mg324,00€100mg507,00€1mL*10mM (DMSO)96,00€Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Fórmula:C20H15Cl3N2OS·HNO3Pureza:98.66%Forma y color:SolidPeso molecular:500.78Kaempferol-3-O-glucorhamnoside
CAS:Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside), a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPKFórmula:C27H30O15Pureza:96.96% - 98.17%Forma y color:SolidPeso molecular:594.5Ref: TM-T5S0089
1mg50,00€5mg97,00€10mg143,00€25mg226,00€50mg340,00€100mg495,00€200mg682,00€1mL*10mM (DMSO)129,00€Scio-323
CAS:Scio-323是一种可口服的 p38丝裂原活化蛋白(MAPK)激酶抑制剂。Fórmula:C27H30FN3O4Pureza:100.00%Forma y color:SolidPeso molecular:479.54Ref: TM-T68139
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg775,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)294,00€(-)-Bornyl acetate
CAS:L-(-)-Bornyl acetate, an enantiomer from hyssop oil, offers antifungal, skin-whitening, and antioxidant benefits, and reduces inflammation.Fórmula:C12H20O2Pureza:≥98%Forma y color:LiquidPeso molecular:196.29Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Fórmula:C23H17NO2Se2Forma y color:SolidPeso molecular:497.31FR 167653
CAS:FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Fórmula:C24H20FN5O6SPureza:98%Forma y color:SolidPeso molecular:525.51Esculin sesquihydrate
CAS:Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimentalFórmula:C15H16O9H2OPureza:98%Forma y color:SolidPeso molecular:367.31p38α inhibitor 5
CAS:The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.Fórmula:C26H23BrF2N2O3Forma y color:SolidPeso molecular:529.37PF-03715455
CAS:PF-03715455 is a potent p38 MAPK inhibitor, reducing TNFα in blood (IC50=1.7 nM) with selectivity for p38α, and may treat COPD.Fórmula:C35H34ClN7O3S2Pureza:98%Forma y color:SolidPeso molecular:700.27UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Fórmula:C30H31F3N8O3SPureza:98.72% - 99.52%Forma y color:SolidPeso molecular:640.68UR13870
CAS:UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.Fórmula:C24H16F2N4Pureza:100% - 98.92%Forma y color:SolidPeso molecular:398.41Quercetin
CAS:Producto controladoFórmula:C15H10O7Forma y color:Yellow Crystalline PowderPeso molecular:302.24AMG-548
CAS:AMG-548, oral p38α inhibitor (Ki=0.5 nM), >1000x selectivity over p38γ/δ, blocks TNFα (IC50=3 nM), also inhibits Wnt/Casein kinase 1δ/ε.Fórmula:C29H27N5OPureza:98%Forma y color:SolidPeso molecular:461.56p38-α MAPK-IN-9
CAS:p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.Fórmula:C19H20N8O2Forma y color:SolidPeso molecular:392.414
