Raf
Las quinasas Raf son componentes clave de la vía de señalización MAPK/ERK, desempeñando un papel crítico en la transmisión de señales desde la membrana celular hasta el núcleo. La activación de Raf conduce a la fosforilación de MEK, que posteriormente activa ERK, influyendo en la división, diferenciación y supervivencia celular. Las mutaciones en Raf, particularmente en B-Raf, están asociadas con varios tipos de cáncer, lo que convierte a Raf en un objetivo crucial en la terapia contra el cáncer. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de Raf para apoyar su investigación en oncología, transducción de señales y desarrollo terapéutico.
Productos de "Raf"
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Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Fórmula:C26H27BrF3N5O2Pureza:98.4%Forma y color:SolidPeso molecular:578.42Ref: TM-T11224
1mg95,00€5mg188,00€10mg354,00€25mg597,00€50mg852,00€100mg1.159,00€1mL*10mM (DMSO)249,00€ZM 336372
CAS:ZM 336372 is a potent and selective c-Raf inhibitor.Fórmula:C23H23N3O3Pureza:97.24% - 97.51%Forma y color:SolidPeso molecular:389.45B-Raf IN 11
CAS:B-Raf IN 11 is a novel selective inhibitor.Fórmula:C17H14BrF2N3O3SPureza:99.46%Forma y color:SolidPeso molecular:458.28K-Ras-IN-1
CAS:K-Ras-IN-1 is a K-Ras inhibitor.Fórmula:C11H13NOSPureza:98.72%Forma y color:SolidPeso molecular:207.29Ref: TM-T5469
2mg46,00€5mg70,00€10mg101,00€25mg182,00€50mg284,00€100mg424,00€200mg588,00€1mL*10mM (DMSO)77,00€LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.3% - 99.92%Forma y color:SolidPeso molecular:502.49Ref: TM-T11898
1mg52,00€5mg122,00€10mg185,00€25mg363,00€50mg567,00€100mg690,00€200mg948,00€500mg1.444,00€1mL*10mM (DMSO)135,00€PROTAC B-Raf degrader 1
CAS:PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.Fórmula:C36H37N5O12SPureza:98%Forma y color:SolidPeso molecular:763.77Anti-Phospho-RAF1 (Ser259) Antibody (5X237)
Anti-Phospho-RAF1 (Ser259) Antibody (5X237) is an antibody targeting Phospho-RAF1 (Ser259). Anti-Phospho-RAF1 (Ser259) Antibody (5X237) can be used in ELISA, WB, IHC, IF.Forma y color:Odour LiquidKobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Forma y color:SolidPeso molecular:419.31Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Fórmula:C20H17FO2SPureza:99.68%Forma y color:SolidPeso molecular:340.41RAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Fórmula:C27H28ClF4N5O2Pureza:99.66%Forma y color:SolidPeso molecular:565.99NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Fórmula:C22H15NO2Pureza:98%Forma y color:SolidPeso molecular:325.36Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Fórmula:C18H19FN8O2SPureza:98%Forma y color:SolidPeso molecular:430.46B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Fórmula:C19H19ClFN3O4SPureza:95.83% - 98.39%Forma y color:SoildPeso molecular:439.89Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 98.60%Forma y color:SolidPeso molecular:462.89MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Fórmula:C33H36N2O3Pureza:97.18%Forma y color:OilPeso molecular:508.65Ref: TM-T24437
1mg37,00€5mg97,00€10mg169,00€25mg291,00€50mg423,00€100mg562,00€500mg1.121,00€1mL*10mM (DMSO)108,00€6H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Fórmula:C20H30ClN3O2S3Pureza:98%Forma y color:SolidPeso molecular:476.12Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Fórmula:C15H8Br2ClNO2Pureza:98.53%Forma y color:SolidPeso molecular:429.49Ref: TM-T4194
2mg40,00€5mg62,00€10mg96,00€25mg164,00€50mg240,00€100mg349,00€200mg492,00€1mL*10mM (DMSO)64,00€Raf inhibitor 1 dihydrochloride
CAS:Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Fórmula:C26H19ClN8HClPureza:98.19% - 98.44%Forma y color:SolidPeso molecular:551.86Ref: TM-T4167
1mg49,00€2mg64,00€5mg103,00€10mg180,00€25mg300,00€50mg445,00€100mg652,00€500mg1.378,00€1mL*10mM (DMSO)188,00€SGX-523
CAS:SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Fórmula:C18H13N7SPureza:100% - 99.49%Forma y color:SolidPeso molecular:359.41Effusanin A
CAS:Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at 3.02 μM.Fórmula:C20H28O5Pureza:98.00%Forma y color:SolidPeso molecular:348.43
