P-gp
La P-glicoproteína es una bomba de eflujo dependiente de ATP que transporta una amplia variedad de sustratos, incluidos medicamentos, toxinas y lípidos, fuera de las células. Desempeña un papel crucial en la resistencia a los medicamentos, particularmente en el cáncer, al reducir la concentración intracelular de agentes quimioterapéuticos. La P-gp también está involucrada en la barrera hematoencefálica, influyendo en la exposición del sistema nervioso central a varios compuestos. En CymitQuimica, ofrecemos una gama de moduladores de la P-gp para apoyar su investigación en resistencia a los medicamentos, farmacocinética y desarrollo terapéutico.
Productos de "P-gp"
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Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Fórmula:C38H36N6O7Pureza:99.93%Forma y color:SolidPeso molecular:688.73Ref: TM-T8426
1mg48,00€2mg65,00€5mg96,00€10mg144,00€25mg246,00€50mg380,00€100mg557,00€1mL*10mM (DMSO)134,00€Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Fórmula:C26H30O11Pureza:93.19% - 93.19%Forma y color:SolidPeso molecular:518.51Ref: TM-TN4761
1mg163,00€5mg320,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)410,00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Fórmula:C39H42N6O11SPureza:99.37%Forma y color:SolidPeso molecular:802.85Ref: TM-T9173
1mg69,00€2mg88,00€5mg126,00€10mg195,00€25mg325,00€50mg467,00€100mg680,00€200mg882,00€500mg1.320,00€1mL*10mM (DMSO)187,00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Fórmula:C34H33N3O5Pureza:100% - 99.62%Forma y color:SolidPeso molecular:563.64Ref: TM-T2657
5mg42,00€10mg63,00€25mg107,00€50mg188,00€100mg283,00€200mg472,00€500mg753,00€1mL*10mM (DMSO)57,00€Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Fórmula:C40H58N4O18S2Pureza:98.13%Forma y color:SolidPeso molecular:947.04Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Fórmula:C45H73NO15Pureza:99.17% - 99.88%Forma y color:SolidPeso molecular:868.06Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Fórmula:C26H37ClN2O4Pureza:99.47%Forma y color:SolidPeso molecular:477.04Ref: TM-T16339
1mg37,00€5mg111,00€10mg187,00€25mg315,00€50mg472,00€100mg658,00€500mg1.378,00€1mL*10mM (DMSO)116,00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.Fórmula:C23H25FN6Pureza:99.31%Forma y color:SolidPeso molecular:404.48coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Fórmula:C20H20O6Pureza:97.09%Forma y color:SolidPeso molecular:356.37MCI826
CAS:MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model ofFórmula:C22H28N2O3SPureza:98.73%Forma y color:SolidPeso molecular:400.53Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Fórmula:C63H111N11O12Pureza:100% - 95%Forma y color:SolidPeso molecular:1214.62Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Fórmula:C24H30O7Pureza:98.39%Forma y color:SolidPeso molecular:430.49Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Fórmula:C20H40O3Pureza:n~9-10Forma y color:Light Amber SemisolidPeso molecular:328.29775Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Fórmula:C23H27FN4O2Pureza:99.73%Forma y color:Crystalline SolidPeso molecular:410.48Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Fórmula:C16H24NO5·CNSPureza:98.19% - ≥95%Forma y color:SolidPeso molecular:368.45Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:SolidPeso molecular:494P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Fórmula:C32H31N5O2Pureza:98.65%Forma y color:SolidPeso molecular:517.62Ref: TM-T12341
5mg50,00€10mg84,00€25mg150,00€50mg219,00€100mg304,00€200mg419,00€1mL*10mM (DMSO)58,00€Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Fórmula:C17H19NO3Pureza:100% - 97.79%Forma y color:SolidPeso molecular:285.34γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Fórmula:C28H42O2Pureza:97.27% - 98.13%Forma y color:SolidPeso molecular:410.63Ref: TM-T19768
1mg47,00€2mg62,00€5mg92,00€10mg144,00€25mg235,00€50mg350,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)97,00€
