Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Productos de "Canal de sodio"
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Tetracaine Hydrochloride
CAS:Applications A local anesthetic used topically in opthalmology. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),Fórmula:C15H24N2O2·ClHForma y color:Off-WhitePeso molecular:300.82Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFórmula:C17H21NO2·HClPureza:98.52%Forma y color:White SolidPeso molecular:307.82Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Fórmula:C19H18ClN3O4S2Pureza:98%Forma y color:SolidPeso molecular:451.95Rufinamide-d2
CAS:Producto controladoApplications Labelled Rufinamide (R701552). Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),Fórmula:C10H6D2F2N4OForma y color:White To Light YellowPeso molecular:240.21Pilsicainide HCl
CAS:Pilsicainide HCl (SUN 1165) is a pure sodium channel blockerFórmula:C17H25ClN2OPureza:99.22% - 99.80%Forma y color:SolidPeso molecular:308.85Mebeverine hydrochloride
CAS:Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gutFórmula:C25H35NO5Pureza:99.81% - 99.81%Forma y color:SolidPeso molecular:429.55SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Fórmula:C19H19Cl3N2O3SPureza:99.11%Forma y color:SolidPeso molecular:461.79Ref: TM-T12931
1mg50,00€5mg97,00€10mg160,00€25mg283,00€50mg472,00€100mg658,00€200mg933,00€500mg1.378,00€1mL*10mM (DMSO)120,00€VX-150
CAS:VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).Fórmula:C21H17F4N2O7PPureza:95.06%Forma y color:SolidPeso molecular:516.34Ref: TM-T9683
1mg70,00€5mg153,00€10mg246,00€25mg494,00€50mg793,00€100mg1.216,00€200mg1.634,00€1mL*10mM (DMSO)167,00€Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Fórmula:C10H13NO4S2Pureza:99.16%Forma y color:SolidPeso molecular:275.34PF-06869206
CAS:PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).Fórmula:C15H14ClF3N4O2Pureza:99.37% - 99.79%Forma y color:SolidPeso molecular:374.754,4'-Dichlorodiphenyldichloroethylene - d8
CAS:Producto controladoApplications 4,4'-DDE - d8 is a metabolite of DDT - d8 (D434197), a synthetic organochlorine insecticide that functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-DDE - d8 has shown to have endocrine disrupting effects on gonadotropin hormones in pituitary gonadotrope cells. References Saschenbrecker, P.W.: Can. J. Comp. Med., 37, 203 (1973); Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989); Zhou, J., et. al.: Environ. Toxicol. Phar., 37, 1194 (2014)Fórmula:C142H8Cl4Forma y color:White SolidPeso molecular:326.07Dyclonine Hydrochloride
CAS:Producto controladoApplications Used as a local anesthetic. References Chawla, H.P.S., et al.: J. Med. Chem., 13, 3, 480 (1970)Fórmula:C18H27NO2·ClHForma y color:NeatPeso molecular:325.87Dibucaine
CAS:Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.Fórmula:C20H29N3O2Pureza:99.83% - 99.88%Forma y color:Colorless Or Almost Colorless Powder SolidPeso molecular:343.46Zonisamide
CAS:Applications Sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant. Neuroprotective & Neuroresearch Product. References Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980), Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987), Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993), Sorkin, E.M., et al.: Drugs, 45, 760 (1993),Fórmula:C8H8N2O3SForma y color:White To Off-WhitePeso molecular:212.233-Hydroxy-4-phenylbenzoic Acid
CAS:Producto controladoApplications 3-Hydroxy-4-phenylbenzoic Acid is a useful reagent for the preparation of spiro[3,4-dihydro-2H-pyrrolo[1,2-a]pyrazine-1,4'-piperidine] derivatives as modulators of sodium ion channel. References Hadida Ruah, S. S., et al.: U.S. Pat. Appl. Publ. (2012), US 20120196869 A1Fórmula:C13H10O3Forma y color:NeatPeso molecular:214.22Tocainide hydrochloride
CAS:Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) is a sodium channel blocker.Fórmula:C11H17ClN2OPureza:98.85%Forma y color:SolidPeso molecular:228.72Ref: TM-T9234
2mg38,00€5mg58,00€10mg96,00€25mg170,00€50mg273,00€100mg439,00€200mg617,00€1mL*10mM (DMSO)65,00€Propafenone
CAS:Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.Fórmula:C21H27NO3Pureza:99.02%Forma y color:SolidPeso molecular:341.44GX 201
CAS:GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Fórmula:C25H27ClF4N2O4SPureza:99.46%Forma y color:SolidPeso molecular:563Clofedanol Hydrochloride
CAS:Producto controladoStability Hygroscopic Applications A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. References Yuizono, T., et al.: Yakugaku Zasshi, 87, 915 (1967), Nomura, A., et al.: Oyo Yakuri, 8, 119 (1974),Fórmula:C17H20ClNO·ClHForma y color:White To Off-WhitePeso molecular:326.26Flunarizine dihydrochloride
CAS:Flunarizine dihydrochloride: a calcium blocker also targeting calmodulin and histamine H1, used for migraine, vertigo, vascular disease, and epilepsy aid.Fórmula:C26H28Cl2F2N2Pureza:99.53% - 99.89%Forma y color:White Crystalline Powder Odorless And TastelessPeso molecular:477.42
