Glucoquinasa
La glucocinasa (GK) es una enzima que cataliza la fosforilación de la glucosa a glucosa-6-fosfato, un paso crítico en la glucólisis. La GK se expresa predominantemente en el hígado y el páncreas, donde desempeña un papel clave en la regulación de los niveles de glucosa en sangre. Los inhibidores de GK son de interés en el estudio de trastornos metabólicos como la diabetes, ya que pueden modular el metabolismo de la glucosa y la secreción de insulina. En CymitQuimica, ofrecemos inhibidores de glucocinasa para apoyar su investigación en diabetes, metabolismo y desarrollo terapéutico.
Productos de "Glucoquinasa"
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Oxfendazole
CAS:Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.Fórmula:C15H13N3O3SPureza:98.81% - 98.99%Forma y color:White To Yellowish PowderPeso molecular:315.35MitoPQ
CAS:MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.Fórmula:C39H46I3N2PPureza:≥98%Forma y color:SolidPeso molecular:954.48AMG-1694
CAS:AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.Fórmula:C23H30F3N3O4S2Pureza:97.97%Forma y color:SolidPeso molecular:533.63POMHEX
CAS:Pomhex, a cell-penetrating ENO2 inhibitor, thwarts glycolysis to combat ENO1-deficient tumors.Fórmula:C17H30NO9PPureza:99.88%Forma y color:SolidPeso molecular:423.4AMG-3969
CAS:AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).Fórmula:C21H20F6N4O3SPureza:99.65%Forma y color:SolidPeso molecular:522.46Ref: TM-TQ0055
1mg120,00€5mg235,00€10mg369,00€25mg612,00€50mg847,00€100mg1.169,00€1mL*10mM (DMSO)269,00€ML251
CAS:ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.Fórmula:C17H13Cl2N3O4SPureza:99.87%Forma y color:SolidPeso molecular:426.27Ref: TM-T64320
1mg133,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€500mg2.717,00€1mL*10mM (DMSO)301,00€AZ PFKFB3 26
CAS:AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.Fórmula:C24H26N4O2Pureza:98.91%Forma y color:SolidPeso molecular:402.49ARRY-403
CAS:ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.Fórmula:C20H18N6O3S2Pureza:98.69%Forma y color:SolidPeso molecular:454.52Glucokinase Protein, Human, Recombinant
Glucokinase belongs to the bacterial glucokinase family.Forma y color:Lyophilized PowderPeso molecular:52.2 kDa (predicted); 52.2 kDa (reducing conditions)WAY-297848
CAS:WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.Fórmula:C13H13ClN2O2SPureza:98.19%Forma y color:SolidPeso molecular:296.77KAN0438757
CAS:KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.Fórmula:C21H18FNO7SPureza:99.34%Forma y color:SolidPeso molecular:447.43Ref: TM-T11741
1mg101,00€5mg192,00€10mg306,00€25mg553,00€50mg760,00€100mg1.035,00€1mL*10mM (DMSO)207,00€MK-0941 free base
CAS:MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.Fórmula:C21H24N4O6SPureza:98.75%Forma y color:SolidPeso molecular:460.5Ref: TM-T12056
1mg87,00€5mg172,00€10mg258,00€25mg425,00€50mg598,00€100mg810,00€1mL*10mM (DMSO)208,00€KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Fórmula:C25H26N6OPureza:98%Forma y color:SolidPeso molecular:426.51ML198
CAS:ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.Fórmula:C17H14N4OPureza:98.31%Forma y color:SolidPeso molecular:290.32YZ9
CAS:Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].Fórmula:C12H10O5Pureza:99.13%Forma y color:SolidPeso molecular:234.2PFK-015
CAS:PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).Fórmula:C17H12N2OPureza:98.94% - 99.7%Forma y color:SolidPeso molecular:260.29Ref: TM-T2455
5mg57,00€10mg88,00€25mg159,00€50mg283,00€100mg419,00€200mg582,00€500mg928,00€1mL*10mM (DMSO)57,00€Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Fórmula:C16H30O2Pureza:99.36%Forma y color:SolidPeso molecular:254.41ML266
CAS:ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.Fórmula:C24H22BrN3O4Pureza:98.45%Forma y color:SolidPeso molecular:496.35Ref: TM-T8990
1mg52,00€2mg74,00€5mg111,00€10mg170,00€25mg344,00€50mg474,00€100mg688,00€500mg1.444,00€1mL*10mM (DMSO)120,00€(E)-3PO
CAS:(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.Fórmula:C13H10N2OPureza:98.8% - 98.8%Forma y color:SolidPeso molecular:210.23Ref: TM-T3260
1mg35,00€2mg48,00€5mg66,00€10mg93,00€25mg162,00€50mg284,00€100mg510,00€1mL*10mM (DMSO)66,00€3PO
CAS:3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.Fórmula:C13H10N2OPureza:97.76% - 99.67%Forma y color:SolidPeso molecular:210.23Ref: TM-T22223
5mg57,00€10mg81,00€25mg127,00€50mg188,00€100mg340,00€200mg507,00€500mg807,00€1mL*10mM (DMSO)64,00€
