ROR
Los receptores órfanos relacionados con el ácido retinoico (RORs) son receptores nucleares que regulan diversos procesos fisiológicos, incluyendo el ritmo circadiano, la respuesta inmunitaria y el metabolismo. Los inhibidores de ROR son de interés en el estudio de enfermedades autoinmunes, trastornos metabólicos y cáncer, ya que pueden modular la expresión génica e influir en las funciones celulares. En CymitQuimica, ofrecemos inhibidores de ROR para apoyar su investigación en inmunología, endocrinología y oncología.
Productos de "ROR"
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RORγt inverse agonist 13
CAS:RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Fórmula:C23H17Cl2F3N2O4Pureza:99%Forma y color:SolidPeso molecular:513.29Ref: TM-T9623
1mg52,00€5mg116,00€10mg178,00€25mg311,00€50mg444,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)131,00€GSK805
CAS:GSK805 is a potent, orally bioavailable and CNS-penetrant RORγt inhibitor.Cost-effective and quality-assured.Fórmula:C23H18Cl2F3NO4SPureza:98% - ≥95%Forma y color:SolidPeso molecular:532.36Ref: TM-T7388
1mg56,00€2mg79,00€5mg120,00€10mg187,00€25mg378,00€50mg462,00€100mg662,00€200mg948,00€1mL*10mM (DMSO)143,00€RORγt Inverse agonist 6
CAS:RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.Fórmula:C28H29ClN6O5Pureza:98.65%Forma y color:SolidPeso molecular:565.02Ref: TM-T12753
1mg62,00€5mg140,00€10mg202,00€25mg324,00€50mg437,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)168,00€XY018
CAS:XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.Fórmula:C23H15F7N2O4Pureza:99.96%Forma y color:SolidPeso molecular:516.37SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Fórmula:C17H10F9NO2Pureza:98.74%Forma y color:SolidPeso molecular:431.25Ref: TM-T4594
1mg42,00€2mg55,00€5mg89,00€10mg115,00€25mg226,00€50mg368,00€100mg547,00€1mL*10mM (DMSO)92,00€ML 209
CAS:ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcriptionFórmula:C25H31NO6Pureza:99.65%Forma y color:SolidPeso molecular:441.52TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Fórmula:C29H30N2O3Pureza:98%Forma y color:SolidPeso molecular:454.56TMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Fórmula:C31H30N2O4Pureza:98.02%Forma y color:SolidPeso molecular:494.58Nobiletin
CAS:Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Fórmula:C21H22O8Pureza:98.78% - 99.76%Forma y color:SolidPeso molecular:402.39Ref: TM-T2834
5mg57,00€10mg88,00€25mg124,00€50mg168,00€100mg265,00€200mg393,00€500mg653,00€1mL*10mM (DMSO)59,00€Methyl-3β-hydroxycholenate
CAS:Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.Fórmula:C25H40O3Pureza:98.78%Forma y color:SolidPeso molecular:388.58SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Fórmula:C15H13F6N3O4S2Pureza:98.93%Forma y color:SolidPeso molecular:477.4TMP780
CAS:TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.Fórmula:C31H30N2O4Pureza:98%Forma y color:SolidPeso molecular:494.58Bevurogant
CAS:Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.Fórmula:C26H28N8O3SPureza:98.78%Forma y color:SolidPeso molecular:532.62TAK-828F
CAS:TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.Fórmula:C28H32FN3O5Pureza:98%Forma y color:SolidPeso molecular:509.57RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Fórmula:C35H60N2O2Pureza:98%Forma y color:SolidPeso molecular:540.86ROR1 ligand-1
ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.Fórmula:C23H30BrN7Forma y color:SolidPeso molecular:484.44MRL-871
CAS:MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.Fórmula:C22H12ClF3N2O3Pureza:99.66%Forma y color:SolidPeso molecular:444.79Ref: TM-T62622
1mg97,00€5mg235,00€10mg395,00€25mg793,00€50mg1.216,00€100mg1.890,00€200mg2.547,00€1mL*10mM (DMSO)263,00€3-Oxo-5β-cholanoic acid
CAS:3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directlyFórmula:C24H38O3Pureza:98.01% - 99.86%Forma y color:SolidPeso molecular:374.56Cedirogant
CAS:Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.Fórmula:C24H20Cl3F3N2O3Pureza:99.57%Forma y color:SolidPeso molecular:547.78Ref: TM-T9635
1mg87,00€5mg170,00€10mg274,00€25mg497,00€50mg742,00€100mg1.103,00€1mL*10mM (DMSO)207,00€Vimirogant
CAS:Vimirogant is a RORγ inhibitor (Ki: <100 nM).Fórmula:C27H35F3N4O3SPureza:98%Forma y color:SolidPeso molecular:552.65
