LRRK2
Los inhibidores de LRRK2 son compuestos que se dirigen y inhiben la actividad de la quinasa rica en repeticiones de leucina 2 (LRRK2), una enzima involucrada en varios procesos celulares, como la autofagia, el tráfico vesicular y la inflamación. Las mutaciones en el gen LRRK2 están asociadas con un mayor riesgo de desarrollar la enfermedad de Parkinson, lo que convierte a LRRK2 en un objetivo significativo para la investigación de enfermedades neurodegenerativas. Los inhibidores de LRRK2 son cruciales para explorar su papel en la enfermedad de Parkinson y para desarrollar posibles estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de inhibidores de LRRK2 para apoyar su investigación en neurodegeneración, señalización de quinasas y desarrollo terapéutico.
Productos de "LRRK2"
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LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Fórmula:C24H26N6OPureza:99.26%Forma y color:SolidPeso molecular:414.5GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Fórmula:C24H18FN3O2Pureza:97.93% - 99.94%Forma y color:SolidPeso molecular:399.42IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Fórmula:C28H29N5OSPureza:98.76% - 99.61%Forma y color:SolidPeso molecular:483.63Ref: TM-T6176
1mg40,00€2mg52,00€5mg88,00€10mg139,00€25mg245,00€50mg406,00€100mg607,00€200mg845,00€1mL*10mM (DMSO)87,00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Forma y color:Odour LiquidGNE-7915
CAS:GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.Fórmula:C19H21F4N5O3Pureza:98% - ≥95%Forma y color:SolidPeso molecular:443.4Ref: TM-T1945
5mg47,00€10mg62,00€25mg114,00€50mg187,00€100mg316,00€200mg410,00€500mg680,00€1mL*10mM (DMSO)50,00€GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Fórmula:C14H16F3N7Pureza:98.01% - 99.96%Forma y color:SolidPeso molecular:339.32Ref: TM-T6031
1mg47,00€2mg60,00€5mg119,00€10mg187,00€25mg376,00€50mg562,00€100mg802,00€500mg1.644,00€1mL*10mM (DMSO)96,00€LRRK2 inhibitor 1
CAS:LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Fórmula:C20H23N5O4Pureza:99.73%Forma y color:SolidPeso molecular:397.43Ref: TM-T11878
1mg74,00€2mg97,00€5mg160,00€10mg264,00€25mg557,00€50mg944,00€100mg1.491,00€1mL*10mM (DMSO)170,00€CZC-25146 hydrochloride
CAS:CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.Fórmula:C22H26ClFN6O4SPureza:98.76%Forma y color:SolidPeso molecular:525PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Fórmula:C17H15N5OPureza:98.61% - 99.62%Forma y color:SolidPeso molecular:305.33CZC-25146
CAS:CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).Fórmula:C22H25FN6O4SPureza:97.68%Forma y color:SolidPeso molecular:488.54MLi-2
CAS:MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Fórmula:C21H25N5O2Pureza:98.96%Forma y color:SolidPeso molecular:379.46Ref: TM-T16115
1mg66,00€2mg96,00€5mg133,00€10mg197,00€25mg435,00€50mg658,00€100mg937,00€1mL*10mM (DMSO)142,00€CCG-1423
CAS:CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Fórmula:C18H13ClF6N2O3Pureza:99.80%Forma y color:SolidPeso molecular:454.75EB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Fórmula:C22H22N8OPureza:98.06%Forma y color:SolidPeso molecular:414.46Ref: TM-T39972
1mg70,00€2mg93,00€5mg156,00€10mg226,00€25mg409,00€50mg610,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)170,00€PFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).Fórmula:C16H16N6OPureza:98.14% - 99.73%Forma y color:SolidPeso molecular:308.34BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Fórmula:C26H30N6O2Pureza:97.44% - 99.61%Forma y color:SolidPeso molecular:458.56CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Fórmula:C22H26Cl2N6O4SPureza:98.21%Forma y color:SolidPeso molecular:541.45Ref: TM-T39202
5mg52,00€10mg75,00€25mg135,00€50mg215,00€100mg319,00€200mg449,00€1mL*10mM (DMSO)64,00€HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Fórmula:C17H20ClN5O3Pureza:99.59%Forma y color:SolidPeso molecular:377.83Ref: TM-T7196
2mg38,00€5mg58,00€10mg94,00€25mg170,00€50mg264,00€100mg380,00€200mg540,00€1mL*10mM (DMSO)65,00€CZC-54252
CAS:CZC-54252 is a potent inhibitor of LRRK2.Fórmula:C22H25ClN6O4SPureza:99.39%Forma y color:SolidPeso molecular:504.99LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Fórmula:C31H38N8O3Pureza:98% - 98.82%Forma y color:SolidPeso molecular:570.69PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Fórmula:C14H16N6OPureza:99.06%Forma y color:SolidPeso molecular:284.32Ref: TM-T7729
2mg35,00€5mg50,00€10mg80,00€25mg135,00€50mg197,00€100mg306,00€200mg442,00€1mL*10mM (DMSO)55,00€
