
GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Productos de "GluR"
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(RS)-3-Hydroxyphenylglycine
CAS:(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.Fórmula:C8H9NO3Pureza:99.92%Forma y color:SolidPeso molecular:167.16MSOP
CAS:MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).Fórmula:C4H10NO6PPureza:98%Forma y color:SolidPeso molecular:199.1ML337
CAS:ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.Fórmula:C21H20FNO3Pureza:99.09%Forma y color:SolidPeso molecular:353.39Ref: TM-T23003
1mg35,00€5mg64,00€10mg97,00€25mg207,00€50mg309,00€100mgA consultar1mL*10mM (DMSO)75,00€(RS)-MCPG
CAS:(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.Fórmula:C10H11NO4Pureza:99.96%Forma y color:SolidPeso molecular:209.2Ref: TM-T3479
1mg35,00€2mg48,00€5mg70,00€10mg87,00€25mg187,00€50mg338,00€100mg502,00€1mL*10mM (DMSO)74,00€Dipraglurant
CAS:Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.Fórmula:C16H12FN3Pureza:98.7%Forma y color:SolidPeso molecular:265.29Ref: TM-T15134
1mg97,00€5mg227,00€10mg329,00€25mg723,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)274,00€VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Fórmula:C21H15FN2O4Pureza:96.68% - 98.44%Forma y color:SolidPeso molecular:378.35Lu AF21934
CAS:Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).Fórmula:C14H16Cl2N2O2Pureza:97.96%Forma y color:SolidPeso molecular:315.2AMN082
CAS:AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.Fórmula:C28H30Cl2N2Pureza:97.23% - 98.34%Forma y color:SolidPeso molecular:465.46NBQX Disodium
CAS:NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.Fórmula:C12H6N4Na2O6SPureza:98.22%Forma y color:SolidPeso molecular:380.24NBQX
CAS:NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.Fórmula:C12H8N4O6SPureza:97.66% - 99.42%Forma y color:SolidPeso molecular:336.28Ref: TM-T4113
1mg40,00€5mg89,00€10mg127,00€25mg246,00€50mg369,00€100mg525,00€200mg757,00€1mL*10mM (DMSO)87,00€LY 541850
CAS:LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from humanFórmula:C9H13NO4Pureza:98%Forma y color:SolidPeso molecular:199.2GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Fórmula:C19H21ClN4O3Pureza:98.02%Forma y color:SolidPeso molecular:388.85Foliglurax
CAS:Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).Fórmula:C23H23N3O3SPureza:98%Forma y color:SolidPeso molecular:421.51MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFórmula:C15H10ClFN2Pureza:98%Forma y color:SolidPeso molecular:272.71cis-PDA
CAS:cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.Fórmula:C7H11NO4Pureza:≥98%Forma y color:White SolidPeso molecular:173.17Decoglurant
CAS:Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.Fórmula:C21H11F6N5Pureza:99.77%Forma y color:SolidPeso molecular:447.34Ref: TM-T15090
1mg55,00€5mg117,00€10mg167,00€25mg309,00€50mg434,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)160,00€VU 0364439
CAS:VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).Fórmula:C18H13Cl2N3O3SPureza:97.90%Forma y color:SolidPeso molecular:422.29CPPHA
CAS:CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.Fórmula:C22H15ClN2O4Pureza:99.61%Forma y color:SolidPeso molecular:406.82VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Fórmula:C14H14Cl2NNaO3Pureza:98%Forma y color:SolidPeso molecular:338.16SIB-1757
CAS:SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)Fórmula:C12H11N3OPureza:97.37%Forma y color:SolidPeso molecular:213.24Ref: TM-T8434
2mg39,00€5mg58,00€10mg94,00€25mg170,00€50mg259,00€100mg363,00€200mg509,00€1mL*10mM (DMSO)77,00€