GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Productos de "GluR"
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Pomaglumetad methionil
CAS:Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.Fórmula:C12H20N2O8S2Pureza:98%Forma y color:SolidPeso molecular:384.43NPS2390
CAS:NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)Fórmula:C19H21N3OPureza:97.13%Forma y color:SolidPeso molecular:307.39VU6001376
CAS:VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).Fórmula:C18H14F2N6OSPureza:98%Forma y color:SolidPeso molecular:400.41Valiglurax
CAS:Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.Fórmula:C16H10F3N5Pureza:97.38%Forma y color:SolidPeso molecular:329.28(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Fórmula:C7H11ClN2O4Forma y color:SolidPeso molecular:222.63LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Fórmula:C29H29N7O4Pureza:98%Forma y color:SolidPeso molecular:539.59CDPPB
CAS:CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).Fórmula:C23H16N4OPureza:99.16%Forma y color:SolidPeso molecular:364.4YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Fórmula:C11H8ClN5O4Pureza:100%Forma y color:SolidPeso molecular:309.66ABP688
CAS:ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.Fórmula:C15H16N2OPureza:97.85%Forma y color:SolidPeso molecular:240.3VU0652835
CAS:VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).Fórmula:C16H19N3O3SPureza:98%Forma y color:SolidPeso molecular:333.41LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Fórmula:C18H20ClNO4Pureza:99% - 99.32%Forma y color:SoildPeso molecular:349.81LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Fórmula:C18H23NO4Pureza:98.06% - 98.71%Forma y color:SolidPeso molecular:317.38CTEP
CAS:CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-foldFórmula:C19H13ClF3N3OPureza:99.17%Forma y color:SolidPeso molecular:391.77Ref: TM-T6457
2mg37,00€5mg52,00€10mg93,00€25mg145,00€50mg256,00€100mg349,00€200mg495,00€1mL*10mM (DMSO)58,00€mGluR3 modulator-1
CAS:1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Fórmula:C16H21N3OPureza:98.99%Forma y color:SolidPeso molecular:271.36VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Fórmula:C22H28N4OPureza:97.27%Forma y color:SolidPeso molecular:364.48Ref: TM-T29118
1mg44,00€5mg84,00€10mg114,00€25mg221,00€50mg329,00€100mg490,00€200mg677,00€1mL*10mM (DMSO)95,00€CPCCOEt
CAS:CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1bFórmula:C13H13NO4Pureza:99.87%Forma y color:SolidPeso molecular:247.25Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Fórmula:C18H11F3N2O3Pureza:97.57%Forma y color:SolidPeso molecular:360.29(S)-4CPG
CAS:(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.Fórmula:C9H9NO4Pureza:99.96%Forma y color:SolidPeso molecular:195.17Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Fórmula:C13H10N2OPureza:99.20%Forma y color:SolidPeso molecular:210.23BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Fórmula:C23H14ClF3N4Pureza:99.62%Forma y color:SolidPeso molecular:438.83
