Células madre
Los inhibidores de células madre son compuestos que actúan específicamente sobre las células madre y sus vías de señalización, afectando su capacidad para autorrenovarse y diferenciarse. Estos inhibidores son cruciales en la investigación centrada en controlar el comportamiento de las células madre, comprender los procesos de desarrollo y desarrollar terapias para enfermedades como el cáncer, donde se cree que las células madre juegan un papel clave. En CymitQuimica, ofrecemos una variedad de inhibidores de células madre para apoyar su investigación en medicina regenerativa, biología del desarrollo y oncología.
Productos de "Células madre"
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PF-5006739
CAS:PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.Fórmula:C22H22FN7OPureza:98%Forma y color:SolidPeso molecular:419.45GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFórmula:C14H13N3OSPureza:98.42%Forma y color:SolidPeso molecular:271.34K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Fórmula:C15H13F2N7O2S2Pureza:99.12%Forma y color:SolidPeso molecular:425.44ALLO-2
CAS:ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Fórmula:C18H12F3N5OPureza:99.19%Forma y color:SolidPeso molecular:371.32Ref: TM-T14188
1mg64,00€5mg140,00€10mg212,00€25mg353,00€50mg500,00€100mg658,00€200mg905,00€1mL*10mM (DMSO)156,00€GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50Fórmula:C14H14N4O3SPureza:95.69%Forma y color:SolidPeso molecular:318.35DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Fórmula:C16H8ClF6N3OPureza:98.15%Forma y color:SolidPeso molecular:407.7STAT3-IN-13
CAS:STAT3-IN-13 is a STAT3 inhibitor with antiproliferative activity that induces apoptosis and can be used to study breast and liver cancer.Fórmula:C21H20N6O3SPureza:98.89%Forma y color:SolidPeso molecular:436.49Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Fórmula:C28H26N2O12P2Pureza:98.97%Forma y color:SolidPeso molecular:644.46Ref: TM-T9646
1mg208,00€5mg518,00€10mg740,00€25mg1.093,00€50mg1.473,00€100mg2.015,00€1mL*10mM (DMSO)737,00€TED-347
CAS:TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.Fórmula:C15H11ClF3NOPureza:99.90%Forma y color:SolidPeso molecular:313.7Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Fórmula:C24H25N7O2Forma y color:SolidPeso molecular:443.50RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFórmula:C17H14FN3O2Pureza:99.58%Forma y color:SoildPeso molecular:311.31Ref: TM-T35566
1mg40,00€2mg52,00€5mg88,00€10mg137,00€25mg227,00€50mg393,00€100mg567,00€1mL*10mM (DMSO)87,00€MM-589 TFA
CAS:MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Fórmula:C30H45F3N8O7Pureza:98%Forma y color:SolidPeso molecular:686.72NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Fórmula:C22H12Cl2F3N3O2SPureza:98.26%Forma y color:SolidPeso molecular:510.32Dendrobium phenol
CAS:Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Fórmula:C16H18O4Pureza:98.66% - 99.48%Forma y color:SolidPeso molecular:274.31Ref: TM-TL0008
1mg49,00€2mg65,00€5mg97,00€10mg156,00€25mg255,00€50mg373,00€100mg555,00€1mL*10mM (DMSO)165,00€SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Fórmula:C14H14ClFN2O2Pureza:99.83%Forma y color:SolidPeso molecular:296.72Ref: TM-T60644
1mg52,00€5mg97,00€10mg149,00€25mg283,00€50mg550,00€100mg792,00€500mg1.605,00€1mL*10mM (DMSO)96,00€3F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFórmula:C15H14N2O4Pureza:98.05% - 98.49%Forma y color:SolidPeso molecular:286.28Pamidronic acid
CAS:Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem CellsFórmula:C3H11NO7P2Pureza:97.72%Forma y color:SolidPeso molecular:235.07Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Fórmula:C14H18ClN3O3SPureza:99.82%Forma y color:SolidPeso molecular:343.83DCN1-IN-2
CAS:DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It effectively mitigates Ang II/TGFβ-induced activation of cardiac fibroblasts and diminishes ISO-induced cardiac fibrosis and remodeling in mice through the selective inhibition of cullin 3.Fórmula:C18H14ClF3N4OSForma y color:SolidPeso molecular:426.84KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Fórmula:C60H74ClN10O14PSPureza:98.12%Forma y color:SolidPeso molecular:1257.78
