Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.22% - 99.53%Forma y color:SolidPeso molecular:429.52Derazantinib
CAS:Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C29H29FN4OPureza:99.71%Forma y color:SolidPeso molecular:468.57Ref: TM-TQ0228
1mg52,00€5mg116,00€10mg169,00€25mg271,00€50mg401,00€100mg597,00€200mg850,00€1mL*10mM (DMSO)125,00€Irpagratinib
CAS:Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.Fórmula:C28H32F2N6O5Pureza:99.08%Forma y color:SolidPeso molecular:570.59Ref: TM-T79850
1mg98,00€5mg232,00€10mg373,00€25mg737,00€50mg1.175,00€100mg1.824,00€200mg2.441,00€1mL*10mM (DMSO)291,00€Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Fórmula:C24H24Cl2N4O4Pureza:99.27% - ≥95%Forma y color:SolidPeso molecular:503.38Ref: TM-T3456
1mg52,00€5mg120,00€10mg177,00€25mg310,00€50mg469,00€100mg707,00€500mg1.415,00€1mL*10mM (DMSO)134,00€Sucralfate
CAS:Sucralfate (Sucrose octasulfate-aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of activeFórmula:C12H54Al16O75S8Pureza:98%Forma y color:White Amorphous PowderPeso molecular:2086.75SM27
CAS:SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.Fórmula:C21H16N2O9S2Pureza:98.83%Forma y color:SolidPeso molecular:504.49TG 100572 Hydrochloride
CAS:TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.Fórmula:C26H27Cl2N5O2Pureza:98%Forma y color:SolidPeso molecular:512.43H3B-6527
CAS:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.Fórmula:C29H34Cl2N8O4Pureza:97.45%Forma y color:SolidPeso molecular:629.54Ref: TM-T7738
1mg70,00€5mg169,00€10mg274,00€25mg530,00€50mg748,00€100mg1.064,00€1mL*10mM (DMSO)283,00€ODM-203
CAS:ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor ImmunityFórmula:C26H21F2N5O2SPureza:99.85%Forma y color:SolidPeso molecular:505.54FIIN-4
CAS:FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.Fórmula:C35H38N8O4Pureza:100%Forma y color:SolidPeso molecular:634.73GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Fórmula:C21H23N7O2S·HClPureza:99.87%Forma y color:SolidPeso molecular:473.98Ref: TM-T6930
10mg52,00€25mg90,00€50mg96,00€100mg140,00€200mg229,00€500mg359,00€1mL*10mM (DMSO)52,00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:482.82Ref: TM-T1792
5mg35,00€10mg51,00€25mg80,00€50mg96,00€100mg144,00€200mg185,00€500mg309,00€1mL*10mM (DMSO)57,00€Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Fórmula:C26H30N6O3Pureza:97.88% - 98.44%Forma y color:White PowderPeso molecular:474.55Ref: TM-T2094
1mg59,00€2mg85,00€5mg116,00€10mg188,00€25mg365,00€50mg555,00€100mg795,00€500mg1.605,00€1mL*10mM (DMSO)120,00€FGFR1 inhibitor-17
CAS:FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.Fórmula:C16H13ClN2O3Forma y color:SolidPeso molecular:316.739ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Forma y color:SolidPeso molecular:375.47Ref: TM-T2358
1mg51,00€2mg72,00€5mg105,00€10mg159,00€25mg279,00€50mg462,00€100mg648,00€1mL*10mM (DMSO)116,00€2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS:Fórmula:C21H15ClF4N4O3Pureza:98%Forma y color:SolidPeso molecular:482.8154Ref: IN-DA00ICN3
1g131,00€5g255,00€10g619,00€25gA consultar10mg30,00€50mg46,00€100mg56,00€250mg69,00€500mg100,00€PROTAC FGFR1 degrader-1
PROTAC FGFR1 degrader-1 (compound S2H) is a targeted degrader of FGFR1, demonstrating an IC50 of 26.81 nM and a DC50 of 39.78 nM in KG1a cells. This compound is composed of a CRBN-type E3 ligase ligand (blue part) Pomalidomide, a target protein ligand (red part) FGFR1ligand-1, and a PROTAC linker (black part) 9-Bromononanoic acid, together forming the conjugate E3LigaseLigand-linker Conjugate 164.Fórmula:C46H54N8O8Forma y color:SolidPeso molecular:846.97Surfen dihydrochloride
CAS:Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a heparin sulfate antagonist with antimicrobial properties and inhibits blockade of signaling.Fórmula:C21H22Cl2N6OPureza:97.08%Forma y color:SolidPeso molecular:445.35PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Fórmula:C18H18Cl2N6OPureza:96.78%Forma y color:SolidPeso molecular:405.28Fanregratinib
CAS:Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.Fórmula:C27H33ClN6O2Forma y color:SolidPeso molecular:509.04
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