ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Productos de "ALK"
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Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Fórmula:C22H18FN7Pureza:98.85% - 99.81%Forma y color:SolidPeso molecular:399.42Ref: TM-T6496
1g1.169,00€2mg47,00€5mg70,00€10mg96,00€25mg160,00€50mg243,00€100mg374,00€200mg552,00€500mg868,00€1mL*10mM (DMSO)77,00€A 83-01
CAS:A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Fórmula:C25H19N5SPureza:97% - 98.20%Forma y color:SolidPeso molecular:421.52TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Fórmula:C23H17N5O2SPureza:98%Forma y color:SolidPeso molecular:427.48Blu-782
CAS:Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)Fórmula:C31H42N6O4Pureza:99.51%Forma y color:SolidPeso molecular:562.7ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Fórmula:C24H23NO3SPureza:99.91%Forma y color:SoildPeso molecular:405.51LDN-193189 HCl
CAS:LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Fórmula:C25H22N6·HClPureza:99.49% - 99.53%Forma y color:SolidPeso molecular:442.94Ref: TM-T6158
1mg44,00€2mg55,00€5mg79,00€10mg87,00€25mg159,00€50mg268,00€100mg401,00€1mL*10mM (DMSO)96,00€ALK kinase inhibitor-1
CAS:SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Fórmula:C28H32FN5O3SPureza:99.84%Forma y color:SolidPeso molecular:537.65AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Fórmula:C18H18N4O3SPureza:98.23%Forma y color:SolidPeso molecular:370.43LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.Fórmula:C25H29N3O3Pureza:100% - 99.85%Forma y color:SolidPeso molecular:419.52IN-1130
CAS:IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).Fórmula:C25H20N6OPureza:99.79%Forma y color:SolidPeso molecular:420.47ALK-IN-5
CAS:ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Fórmula:C24H25FN6O3Pureza:98%Forma y color:SolidPeso molecular:464.49TL13-22
CAS:TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .Fórmula:C45H55ClN10O9SPureza:99.13%Forma y color:SolidPeso molecular:947.5OD36 hydrochloride
CAS:OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFórmula:C16H16Cl2N4O2Pureza:99.85%Forma y color:SolidPeso molecular:367.23SB-505124
CAS:SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.Fórmula:C20H21N3O2Pureza:97.19% - 99.92%Forma y color:SolidPeso molecular:335.4Ref: TM-T2462
1mg40,00€2mg52,00€5mg88,00€10mg127,00€25mg221,00€50mg374,00€100mg547,00€500mg1.159,00€1mL*10mM (DMSO)139,00€LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Fórmula:C25H22N6Pureza:98% - 98.71%Forma y color:SolidPeso molecular:406.48ALK-IN-27
CAS:Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.Fórmula:C23H22ClFN6OPureza:99.71%Forma y color:SolidPeso molecular:452.91EML4-ALK kinase inhibitor 1
CAS:Potent oral EML4-ALK inhibitor with a 1 nM IC50.Fórmula:C31H48N8O3Pureza:99.14%Forma y color:SolidPeso molecular:580.76Ref: TM-T11184
1mg96,00€5mg212,00€10mg316,00€25mg510,00€50mg695,00€100mg940,00€500mg1.872,00€1mL*10mM (DMSO)270,00€LDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Fórmula:C25H24Cl2N6Pureza:99.78%Forma y color:SolidPeso molecular:479.4SB-431542
CAS:SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.Fórmula:C22H16N4O3Pureza:100% - 99.87%Forma y color:SolidPeso molecular:384.39ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Fórmula:C22H16N4OPureza:98.3% - ≥95%Forma y color:SolidPeso molecular:352.39
