ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Productos de "ALK"
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Zotizalkib
CAS:TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.Fórmula:C21H20F3N5O3Pureza:98.7%Forma y color:SolidPeso molecular:447.41SB 525334
CAS:SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).Fórmula:C21H21N5Pureza:98.39% - ≥95%Forma y color:SolidPeso molecular:343.42Itacnosertib
CAS:Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.Fórmula:C26H28N8OPureza:99.38%Forma y color:SolidPeso molecular:468.55GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.Fórmula:C25H23N5O2Pureza:98.03% - 98.79%Forma y color:SolidPeso molecular:425.48R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Fórmula:C20H18FN5OPureza:99.61%Forma y color:SolidPeso molecular:363.39Ref: TM-T16708
1mg47,00€5mg87,00€10mg137,00€25mg264,00€50mg399,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)97,00€5-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Fórmula:C12H9N3SPureza:97%Forma y color:SolidPeso molecular:227.29Ref: TM-T50042
2mg46,00€5mg64,00€10mg95,00€25mg145,00€50mg212,00€100mg319,00€200mg455,00€1mL*10mM (DMSO)64,00€ALK2-IN-2
CAS:ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Fórmula:C28H27N5O2SPureza:99.55%Forma y color:SolidPeso molecular:497.61Ref: TM-T10287
1mg62,00€5mg135,00€10mg207,00€25mg325,00€50mg449,00€100mg620,00€200mg843,00€1mL*10mM (DMSO)149,00€A 83-01 sodium salt
CAS:A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Fórmula:C25H19N5NaSForma y color:SolidPeso molecular:444.51CEP-28122
CAS:CEP-28122 is a highly potent and selective orally active ALK inhibitor.Fórmula:C28H35ClN6O3Pureza:100%Forma y color:SolidPeso molecular:539.07Vactosertib Hydrochloride
CAS:Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Fórmula:C22H19ClFN7Pureza:98.03%Forma y color:SolidPeso molecular:435.89Ref: TM-T15262
1mg35,00€5mg74,00€10mg97,00€25mg169,00€50mg255,00€100mg395,00€200mg563,00€1mL*10mM (DMSO)81,00€N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Fórmula:C22H18BrN7Pureza:99.27%Forma y color:SolidPeso molecular:460.33Ref: TM-T9837
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)226,00€K02288
CAS:K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.Fórmula:C20H20N2O4Pureza:98% - 99.81%Forma y color:SolidPeso molecular:352.38
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