Receptor TAM
Los inhibidores de los receptores TAM están dirigidos a la familia de receptores tirosina quinasa TAM, que incluye Tyro3, Axl y Mer. Estos receptores están involucrados en la regulación de las respuestas inmunitarias, la supervivencia celular y la eliminación de células apoptóticas. La desregulación de los receptores TAM está implicada en el cáncer, enfermedades autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos inhibidores de los receptores TAM para apoyar su investigación en inmunología, oncología e inflamación.
Productos de "Receptor TAM"
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DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Fórmula:C41H42FN5O7Pureza:99.28%Forma y color:SolidPeso molecular:735.8TAM-IN-2
CAS:TAM-IN-2 is an inhibitor of TAM.Fórmula:C31H27F2N7O3Pureza:98.09% - 99.74%Forma y color:SolidPeso molecular:583.59UNC2541
CAS:UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Fórmula:C24H34FN7O2Pureza:98.33%Forma y color:SolidPeso molecular:471.57UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Fórmula:C22H29FN6Pureza:98.91%Forma y color:SolidPeso molecular:396.5Ref: TM-T21302
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg311,00€50mg512,00€100mg730,00€1mL*10mM (DMSO)96,00€Ningetinib
CAS:Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Fórmula:C31H29FN4O5Pureza:99.77% - 99.95%Forma y color:SolidPeso molecular:556.58Bemcentinib
CAS:Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.Fórmula:C30H34N8Pureza:97% - 99.8%Forma y color:SolidPeso molecular:506.64Ref: TM-T6269
1mg40,00€2mg52,00€5mg87,00€10mg144,00€25mg212,00€50mg274,00€100mg465,00€200mg622,00€500mg948,00€RU-302
CAS:RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.Fórmula:C24H24F3N3O2SPureza:99.45%Forma y color:SolidPeso molecular:475.53Ref: TM-T16806
1mg43,00€5mg96,00€10mg150,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)96,00€AXL-IN-15
CAS:AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1Fórmula:C26H32F3N9O3Pureza:98%Forma y color:SolidPeso molecular:575.59MerTK/Axl-IN-1
CAS:MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.Fórmula:C40H47FN6O4Forma y color:SolidPeso molecular:694.84BMS 777607
CAS:BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.Fórmula:C25H19ClF2N4O4Pureza:100% - 99.89%Forma y color:SolidPeso molecular:512.89Ref: TM-T2699
1mg35,00€5mg79,00€10mg124,00€25mg217,00€50mg359,00€100mg533,00€500mg1.169,00€1mL*10mM (DMSO)92,00€UNC 569 hydrochloride
UNC 569 hydrochloride: reversible ATP-competitive Mer inhibitor, IC50 2.9 nM, Ki 4.3 nM, also inhibits Axl/Tyro3; used in leukemia, teratoid tumor studies.Fórmula:C22H30ClFN6Pureza:100%Forma y color:SolidPeso molecular:432.96SGI-7079
CAS:SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.Fórmula:C26H26FN7Pureza:95.05% - 99.26%Forma y color:SolidPeso molecular:455.53Ref: TM-T6982
2mg42,00€5mg62,00€10mg97,00€25mg188,00€50mg243,00€100mg354,00€500mg825,00€1mL*10mM (DMSO)67,00€XL092
CAS:XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.Fórmula:C29H25FN4O5Pureza:98.60%Forma y color:SolidPeso molecular:528.53LDC1267
CAS:LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).Fórmula:C30H26F2N4O5Pureza:99.38% - 99.76%Forma y color:SolidPeso molecular:560.55Ref: TM-T2311
1mg35,00€2mg52,00€5mg77,00€10mg105,00€25mg168,00€50mg248,00€100mg419,00€1mL*10mM (DMSO)93,00€Dubermatinib
CAS:Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.Fórmula:C24H30ClN7O2SPureza:98.65% - 98.92%Forma y color:SolidPeso molecular:516.06Ningetinib Tosylate
CAS:Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Fórmula:C38H37FN4O8SPureza:99.93%Forma y color:SolidPeso molecular:728.79AXL-IN-14
CAS:AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.Fórmula:C32H24F2N4O4Pureza:98%Forma y color:SolidPeso molecular:566.55MerTK-IN-1
CAS:MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.Fórmula:C23H26N8O4Forma y color:SolidPeso molecular:478.50Sitravatinib malate
CAS:Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5Fórmula:C37H35F2N5O9SPureza:98%Forma y color:SolidPeso molecular:763.76UNC2881
CAS:UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.Fórmula:C25H33N7O2Pureza:98.97% - 99.74%Forma y color:SolidPeso molecular:463.58
