FLT
Los inhibidores de la FLT (quinasa de tirosina similar a Fms) son compuestos que se dirigen a los receptores FLT, los cuales están involucrados en la regulación de la angiogénesis a través de la vía del VEGF (factor de crecimiento endotelial vascular). Los receptores FLT desempeñan un papel crucial en el desarrollo de nuevos vasos sanguíneos en los tumores. Inhibir los receptores FLT puede reducir eficazmente la angiogénesis y el crecimiento tumoral, lo que hace que estos inhibidores sean importantes en la terapia contra el cáncer. En CymitQuimica, ofrecemos una selección de inhibidores de FLT de alta calidad para apoyar su investigación en oncología, biología vascular y angiogénesis.
Productos de "FLT"
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FLT3-IN-2
CAS:FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).Fórmula:C21H16ClF3N4Pureza:97.57% - 98.53%Forma y color:SolidPeso molecular:416.83Ref: TM-T1938
1mg43,00€2mg56,00€5mg87,00€10mg119,00€25mg210,00€50mg350,00€100mg505,00€1mL*10mM (DMSO)87,00€5'-Fluoroindirubinoxime
CAS:5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).Fórmula:C16H10FN3O2Pureza:100%Forma y color:SolidPeso molecular:295.27UNC2025 2HCl (1429881-91-3(free base))
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.Fórmula:C28H42Cl2N6OPureza:99.71%Forma y color:SolidPeso molecular:549.62Gilteritinib hemifumarate
CAS:Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment ofFórmula:C29H44N8O3C4H4O4Pureza:98.07%Forma y color:SolidPeso molecular:610.75Dapolsertib
CAS:Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.Fórmula:C15H18Br2N4O2Pureza:99.61%Forma y color:SolidPeso molecular:446.14FLT3-IN-3
CAS:FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.Fórmula:C27H38N8OPureza:99.25%Forma y color:SolidPeso molecular:490.64Ref: TM-T11298
1mg107,00€5mg259,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€500mg2.717,00€1mL*10mM (DMSO)278,00€SB1317 hydrochloride (1204918-72-8(free base))
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).Fórmula:C23H25ClN4OPureza:99.84%Forma y color:SolidPeso molecular:408.92Ref: TM-T4227
1mg49,00€2mg69,00€5mg113,00€10mg180,00€25mg324,00€50mg393,00€100mg585,00€1mL*10mM (DMSO)124,00€BPR1J-097 hydrochloride (1327167-19-0(free base))
BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.Fórmula:C27H29ClN6O3SPureza:98% - 98.54%Forma y color:SolidPeso molecular:553.07UNC2541
CAS:UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Fórmula:C24H34FN7O2Pureza:98.33%Forma y color:SolidPeso molecular:471.57HM43239
CAS:HM43239: oral FLT3 inhibitor; IC50: FLT3 WT 1.1nM, ITD 1.8nM, D835Y 1.0nM; blocks p-STAT5/p-ERK; affects SYK, JAK1/2, TAK1; halts leukemia cell growth.Fórmula:C29H33ClN6Pureza:98.56%Forma y color:SolidPeso molecular:501.07TG-46
CAS:TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Fórmula:C26H34N6O3SPureza:100% - 99.87%Forma y color:SolidPeso molecular:510.65BPR1K871
CAS:BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values ofFórmula:C25H28ClN7O2SForma y color:SolidPeso molecular:526.05AXL-IN-13
CAS:AXL-IN-13: potent, oral AXL inhibitor, IC50=1.6nM, Kd=0.26nM, anti-cancer, inhibits EMT, cell migration & invasion.Fórmula:C34H41FN6O5Pureza:99.38%Forma y color:SolidPeso molecular:632.72Gilteritinib
CAS:Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,Fórmula:C29H44N8O3Pureza:97.75% - 99.74%Forma y color:SolidPeso molecular:552.71Ref: TM-T4409
1g1.359,00€1mg40,00€2mg55,00€5mg89,00€10mg120,00€25mg187,00€50mg276,00€100mg434,00€500mg1.008,00€TAS05567
CAS:TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM).Fórmula:C21H29N9O2Pureza:98%Forma y color:SolidPeso molecular:439.51Anti-FLT1 Antibody (6S618)
Anti-FLT1 Antibody (6S618) is an antibody targeting FLT1. Anti-FLT1 Antibody (6S618) can be used in ELISA, IHC.Forma y color:Odour LiquidTCS 359
CAS:TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.Fórmula:C18H20N2O4SPureza:99.31%Forma y color:SolidPeso molecular:360.43HPK1-IN-2
CAS:HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50<0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.Fórmula:C19H20N6OSPureza:97.31%Forma y color:SolidPeso molecular:380.47Ref: TM-T9017
1mg78,00€5mg143,00€10mg230,00€25mg385,00€50mg548,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)170,00€Flonoltinib
CAS:Flonoltinib (JAK2/FLT3-IN-1) is an orally active and efficient JAK2/FLT3 inhibitor with anti-cancer properties.Fórmula:C25H34FN7OPureza:99.52%Forma y color:SolidPeso molecular:467.58FLT3-ITD-IN-2
FLT3-ITD-IN-2 (Compound A1) is an inhibitor of the FLT3-ITD kinase, exhibiting an IC50 of 2.12 nM. It effectively suppresses the proliferation of the FLT3-dependent human AML cell line MOLM-13, with an IC50 of 25.65 nM. FLT3-ITD-IN-2 demonstrates antitumor activity against acute myeloid leukemia.Fórmula:C39H50N8O6Forma y color:SolidPeso molecular:726.86
