FLT
Los inhibidores de la FLT (quinasa de tirosina similar a Fms) son compuestos que se dirigen a los receptores FLT, los cuales están involucrados en la regulación de la angiogénesis a través de la vía del VEGF (factor de crecimiento endotelial vascular). Los receptores FLT desempeñan un papel crucial en el desarrollo de nuevos vasos sanguíneos en los tumores. Inhibir los receptores FLT puede reducir eficazmente la angiogénesis y el crecimiento tumoral, lo que hace que estos inhibidores sean importantes en la terapia contra el cáncer. En CymitQuimica, ofrecemos una selección de inhibidores de FLT de alta calidad para apoyar su investigación en oncología, biología vascular y angiogénesis.
Productos de "FLT"
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JTV-519 free base
CAS:JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmicFórmula:C25H32N2O2SPureza:98%Forma y color:SolidPeso molecular:424.6MRX-2843
CAS:MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).Fórmula:C29H40N6OPureza:99.63%Forma y color:SolidPeso molecular:488.67Ref: TM-T16144
1mg65,00€5mg144,00€10mg227,00€25mg454,00€50mg655,00€100mg933,00€1mL*10mM (DMSO)157,00€Fostamatinib Disodium
CAS:Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.Fórmula:C23H24FN6O9P·2NaPureza:96.13% - 98.95%Forma y color:SolidPeso molecular:624.42Ref: TM-T2605
1mg47,00€2mg55,00€5mg88,00€10mg124,00€25mg221,00€50mg374,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)116,00€3-Hydroxy Midostaurin
CAS:3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM inFórmula:C35H30N4O5Pureza:98%Forma y color:SolidPeso molecular:586.648OTS447
CAS:OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .Fórmula:C27H32ClN3O2Pureza:97.72%Forma y color:SolidPeso molecular:466.027BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.Fórmula:C16H10BrN3O2Pureza:99.77%Forma y color:SolidPeso molecular:356.17Ref: TM-T22012
5mg46,00€10mg64,00€25mg116,00€50mg178,00€100mg284,00€200mg401,00€1mL*10mM (DMSO)52,00€Fostamatinib
CAS:Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.Fórmula:C23H26FN6O9PPureza:93.08% - 99.38%Forma y color:SolidPeso molecular:580.46Ref: TM-T6115
1mg43,00€2mg57,00€5mg88,00€10mg118,00€25mg210,00€50mg335,00€100mg548,00€500mg1.198,00€1mL*10mM (DMSO)101,00€FN-1501
CAS:FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Fórmula:C22H25N9OPureza:96.35%Forma y color:SolidPeso molecular:431.49Ref: TM-T15335
1mg92,00€5mg187,00€10mg311,00€25mg567,00€50mg852,00€100mg1.159,00€1mL*10mM (DMSO)215,00€JAK3-IN-14
CAS:JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.Fórmula:C18H13N3OPureza:98.98%Forma y color:SoildPeso molecular:287.32Ref: TM-T67754
1mg215,00€5mg620,00€10mg904,00€25mg1.320,00€50mg1.786,00€100mg2.432,00€1mL*10mM (DMSO)540,00€FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:83.7 kDa (predicted); 110-120 kDa (reducing condition, due to glycosylation)VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Forma y color:Lyophilized PowderPeso molecular:85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.GTP-14564
CAS:GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.Fórmula:C15H10N2OPureza:99.69%Forma y color:SolidPeso molecular:234.25AMG 925
CAS:AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.Fórmula:C26H29N7O2Pureza:99.75%Forma y color:SolidPeso molecular:471.55(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Fórmula:C23H24N4OPureza:97% - 98.03%Forma y color:SolidPeso molecular:372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€SKLB4771
CAS:SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.Fórmula:C25H27N7O3S2Pureza:100% - 98.27%Forma y color:SolidPeso molecular:537.66Ref: TM-T2051
1mg66,00€2mg87,00€5mg131,00€10mg187,00€25mg393,00€50mg587,00€100mg835,00€500mg1.700,00€1mL*10mM (DMSO)157,00€FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag.Pureza:97.5%Forma y color:Lyophilized PowderPeso molecular:35.6 kDa (predicted)AKN-028
CAS:AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.Fórmula:C17H14N6Pureza:97.3%Forma y color:SolidPeso molecular:302.33FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Forma y color:Lyophilized PowderPeso molecular:61.1 kDa (predicted)
